European Journal of Nuclear Medicine
1619-7089
0340-6997
Cơ quản chủ quản: Springer Verlag , SPRINGER
Lĩnh vực:
Medicine (miscellaneous)Radiology, Nuclear Medicine and Imaging
Phân tích ảnh hưởng
Thông tin về tạp chí
Các bài báo tiêu biểu
Does diabetes affect [18F]FDG standardised uptake values in lung cancer?
Tập 29 Số 10 - Trang 1324-1327 - 2002
Comparison of radioiodine biokinetics following the administration of recombinant human thyroid stimulating hormone and after thyroid hormone withdrawal in thyroid carcinoma
Tập 30 Số 10 - Trang 1371-1377 - 2003
A comparison of CT- and MR-based attenuation correction in neurological PET
Tập 41 - Trang 1176-1189 - 2014
To assess the quantitative accuracy of current MR attenuation correction (AC) methods in neurological PET, in comparison to data derived using CT AC. This retrospective study included 25 patients who were referred for a neurological FDG PET examination and were imaged sequentially by PET/CT and simultaneous PET/MR. Differences between activity concentrations derived using Dixon and ultrashort echo time (UTE) MR-based AC and those derived from CT AC were compared using volume of interest and voxel-based approaches. The same comparisons were also made using PET data represented as SUV ratios (SUVr) using grey matter cerebellum as the reference region. Extensive and statistically significant regional underestimations of activity concentrations were found with both Dixon AC (P < 0.001) and UTE AC (P < 0.001) in all brain regions when compared to CT AC. The greatest differences were found in the cortical grey matter (Dixon AC 21.3 %, UTE AC 15.7 %) and cerebellum (Dixon AC 19.8 %, UTE AC 17.3 %). The underestimation using UTE AC was significantly less than with Dixon AC (P < 0.001) in most regions. Voxel-based comparisons showed that all cortical grey matter and cerebellum uptake was underestimated with Dixon AC compared to CT AC. Using UTE AC the extent and significance of these differences were reduced. Inaccuracies in cerebellar activity concentrations led to a mixture of predominantly cortical underestimation and subcortical overestimation in SUVr PET data for both MR AC methodologies. MR-based AC results in significant underestimation of activity concentrations throughout the brain, which makes the use of SUVr data difficult. These effects limit the quantitative accuracy of neurological PET/MR.
A comparison of bone scanning and radiology in the assessment of patients with symptomatic Paget's disease
Tập 5 - Trang 417-421 - 1980
Bone scans and X-rays from 23 subjects with symptomatic Paget's disease were evaluated. One-hundred and twenty-seven sites of Pagetoid involvement were found, of which 120 (94.5%) were recognised on the bone scan as compared to 94 (74%) on X-ray. The anatomical distribution and relationship of lesions on scan and X-ray to the patient's symptoms are also discussed. It is concluded that the bone scan is more sensitive than radiology in detecting Paget's disease and only rarely will a lesion that is seen on X-ray not be visualised by scanning.
Erratum to: Development of a nomogram combining clinical staging with 18F-FDG PET/CT image features in non-small-cell lung cancer stage I–III
Tập 43 - Trang 1933-1933 - 2016
In vivo imaging of axonal transport using MRI: aging and Alzheimer’s disease
Tập 35 - Trang 89-92 - 2008
MRI using manganese as a trans-synaptic axonal tracing agent can unveil dynamics of axonal transport in living subjects. We use this technology to test the hypotheses if impaired axonal transport is a significant pathophysiological process in aging and early Alzheimer’s disease (AD) and in part accounting for “selective vulnerability” of projection neurons in AD. To allow quantitative assessment of axonal transport in vivo, we developed voxel-based statistical mapping technology as well as a tracer kinetic modeling method based on mass transport for manganese-enhanced MRI to estimate axonal transport rates in aging rats and AD transgenic mice. These techniques demonstrated manganese-enhanced signal changes in axonal projections of the olfactory tract and decreased axonal transport rates in rodent models of aging and AD. Altered axonal transport may be a critical pathophysiological process in aging and AD. Manganese-enhanced MRI provides exciting opportunities for the investigations of altered axonal transport in AD and related disorders.
Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer Abstract
Purpose
Probe-based dynamic (4-D) imaging modalities capture breast intratumor heterogeneity both spatially and kinetically. Characterizing heterogeneity through tumor sub-populations with distinct functional behavior may elucidate tumor biology to improve targeted therapy specificity and enable precision clinical decision making.
Methods
We propose an unsupervised clustering algorithm for 4-D imaging that integrates Markov-Random Field (MRF) image segmentation with time-series analysis to characterize kinetic intratumor heterogeneity. We applied this to dynamic FDG PET scans by identifying distinct time-activity curve (TAC) profiles with spatial proximity constraints. We first evaluated algorithm performance using simulated dynamic data. We then applied our algorithm to a dataset of 50 women with locally advanced breast cancer imaged by dynamic FDG PET prior to treatment and followed to monitor for disease recurrence. A functional tumor heterogeneity (FTH) signature was then extracted from functionally distinct sub-regions within each tumor. Cross-validated time-to-event analysis was performed to assess the prognostic value of FTH signatures compared to established histopathological and kinetic prognostic markers.
Results
Adding FTH signatures to a baseline model of known predictors of disease recurrence and established FDG PET uptake and kinetic markers improved the concordance statistic (C-statistic) from 0.59 to 0.74 (p = 0.005). Unsupervised hierarchical clustering of the FTH signatures identified two significant (p < 0.001) phenotypes of tumor heterogeneity corresponding to high and low FTH. Distributions of FDG flux, or Ki, were significantly different (p = 0.04) across the two phenotypes.
Conclusions
Our findings suggest that imaging markers of FTH add independent value beyond standard PET imaging metrics in predicting recurrence-free survival in breast cancer and thus merit further study.
- 2021