Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response

Bernstein, 1999, Immune response to influenza vaccination in a large healthy elderly population, Vaccine, 17, 82, 10.1016/S0264-410X(98)00117-0 Gardner, 2001, Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population, Vaccine, 19, 4610, 10.1016/S0264-410X(01)00246-8 Murasko, 2002, Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly, Exp Gerontol, 37, 427, 10.1016/S0531-5565(01)00210-8 Wang, 2014, Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires, J Immunol, 192, 603, 10.4049/jimmunol.1301384 Shi, 2005, Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell, J Immunol, 175, 3262, 10.4049/jimmunol.175.5.3262 Landgren, 2009, Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: A prospective study, Blood, 113, 5412, 10.1182/blood-2008-12-194241 Blade, 2008, Pathogenesis and progression of monoclonal gammopathy of undetermined significance, Leukemia, 22, 1651, 10.1038/leu.2008.203 Kyle, 2006, Prevalence of monoclonal gammopathy of undetermined significance, N Engl J Med, 354, 1362, 10.1056/NEJMoa054494 Kyle, 2010, Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management, Leukemia, 24, 1121, 10.1038/leu.2010.60 Kyle, 2007, Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma, N Engl J Med, 356, 2582, 10.1056/NEJMoa070389 Zemble, 2011, The relationship between hypogammaglobulinemia, monoclonal gammopathy of undetermined significance and humoral immunodeficiency: A case series, J Clin Immunol, 31, 737, 10.1007/s10875-011-9548-0 Baldini, 1996, Role of different hematologic variables in defining the risk of malignant transformation in monoclonal gammopathy, Blood, 87, 912, 10.1182/blood.V87.3.912.bloodjournal873912 Gregersen, 1998, The risk of bacteremia in patients with monoclonal gammopathy of undetermined significance, Eur J Haematol, 61, 140, 10.1111/j.1600-0609.1998.tb01075.x Kristinsson, 2012, Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study, Haematologica, 16, 854, 10.3324/haematol.2011.054015 European Centre for Disease Prevention and Control. ECDC guidance: priority risk groups for influenza vaccination. European Centre for Disease Prevention and Control web site. 2008. Available at: http://www.ecdc.europa.eu/en/publications/Publications/Forms/ECDC_DispForm.aspx?ID=315. Accessed February 10, 2012. Demicheli, 2007, Vaccines for preventing influenza in healthy adults, Cochrane Database Syst Rev, CD001269 Jefferson, 2005, Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review, Lancet, 366, 1165, 10.1016/S0140-6736(05)67339-4 Tete, 2014, Hampered influenza-specific IgG B cell responses whereas IgM and IgA responses are maintained in monoclonal gammopathy of undetermined significance, Hematology and Leukemia, 2, 5, 10.7243/2052-434X-2-5 Tete, 2013, IgG antibody and TH1 immune responses to influenza vaccination negatively correlate with M-protein burden in monoclonal gammopathy of undetermined significance, Hematology and Leukemia, 1, 3, 10.7243/2052-434X-1-3 Rajewsky, 1996, Clonal selection and learning in the antibody system, Nature, 381, 751, 10.1038/381751a0 Wu, 2010, High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations, Blood, 116, 1070, 10.1182/blood-2010-03-275859 Wrammert, 2011, Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection, J Exp Med, 208, 181, 10.1084/jem.20101352 Foreman, 2008, VH gene usage and CDR3 analysis of B cell receptor in the peripheral blood of patients with PBC, Autoimmunity, 41, 80, 10.1080/08916930701619656 Baranzini, 1999, B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions, J Immunol, 163, 5133, 10.4049/jimmunol.163.9.5133 Gibson, 2009, B-cell diversity decreases in old age and is correlated with poor health status, Aging Cell, 8, 18, 10.1111/j.1474-9726.2008.00443.x Ademokun, 2011, Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages, Aging Cell, 10, 922, 10.1111/j.1474-9726.2011.00732.x Collette, 2003, New methods and software tools for high throughput CDR3 spectratyping. Application to T lymphocyte repertoire modifications during experimental malaria, J Immunol Methods, 278, 105, 10.1016/S0022-1759(03)00225-4 Matsumoto, 2003, Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis, J Immunol, 170, 4846, 10.4049/jimmunol.170.9.4846 Peggs, 2003, Reconstitution of T-cell repertoire after autologous stem cell transplantation: Influence of CD34 selection and cytomegalovirus infection, Biol Blood Marrow Transplant, 9, 198, 10.1016/S1083-8791(03)70010-X Bulmer, 1979 Dhodapkar, 2003, Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathy, J Exp Med, 198, 1753, 10.1084/jem.20031030 Dhodapkar, 2005, Immune response to premalignancy: insights from patients with monoclonal gammopathy, Ann N Y Acad Sci, 1062, 22, 10.1196/annals.1358.004 Spisek, 2007, Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy, J Exp Med, 204, 831, 10.1084/jem.20062387 Blotta, 2009, Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance, Blood, 114, 3276, 10.1182/blood-2009-04-219436 Ratta, 2002, Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6, Blood, 100, 230, 10.1182/blood.V100.1.230 Beyer, 2006, In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma, Blood, 107, 3940, 10.1182/blood-2005-09-3671 Paiva, 2011, Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma, Leukemia, 25, 697, 10.1038/leu.2010.320 Paiva, 2010, Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders, Cytometry B Clin Cytom, 78, 239 Cox, 1994, An early humoral immune response in peripheral blood following parenteral inactivated influenza vaccination, Vaccine, 12, 993, 10.1016/0264-410X(94)90334-4 Corti, 2010, Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine, J Clin Invest, 120, 1663, 10.1172/JCI41902 Wrammert, 2008, Rapid cloning of high-affinity human monoclonal antibodies against influenza virus, Nature, 453, 667, 10.1038/nature06890 Bendelac, 2001, Autoreactivity by design: innate B and T lymphocytes, Nat Rev Immunol, 1, 177, 10.1038/35105052 Kumar, 2005, Prognostic value of circulating plasma cells in monoclonal gammopathy of undetermined significance, J Clin Oncol, 23, 5668, 10.1200/JCO.2005.03.159 Billadeau, 1996, Clonal circulating cells are common in plasma cell proliferative disorders: a comparison of monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and active myeloma, Blood, 88, 289, 10.1182/blood.V88.1.289.289 Ichiyoshi, 1994, Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments, J Exp Med, 180, 885, 10.1084/jem.180.3.885 Wardemann, 2003, Predominant autoantibody production by early human B cell precursors, Science, 301, 1374, 10.1126/science.1086907 Rosner, 2001, Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than nonmutated genes, Immunology, 103, 179, 10.1046/j.1365-2567.2001.01220.x