Molecular targets of dietary agents for prevention and therapy of cancer
Tóm tắt
Từ khóa
Tài liệu tham khảo
1950 Mortality Data-CDC/NCHS N, Mortality Revised.
2002 Mortality Data: US Mortality Public Use Data Tape, NCHS, Centers for Disease Control and Prevention, 2004.
Ziegler, 1993, Migration patterns and breast cancer risk in Asian-American women, J Natl Cancer Inst, 85, 1819, 10.1093/jnci/85.22.1819
Haenszel, 1968, Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States, J Natl Cancer Inst, 40, 43
Kolonel, 2004, The multiethnic cohort study: exploring genes, lifestyle and cancer risk, Nat Rev Cancer, 4, 519, 10.1038/nrc1389
Wiencke, 2004, Impact of race/ethnicity on molecular pathways in human cancer, Nat Rev Cancer, 4, 79, 10.1038/nrc1257
Locatelli, 2004, The heritability of breast cancer: a Bayesian correlated frailty model applied to Swedish twins data, Twin Res, 7, 182, 10.1375/136905204323016168
Wong, 2005, Phenotypic differences in genetically identical organisms: the epigenetic perspective, Hum Mol Genet, 14 Spec No 1, R11, 10.1093/hmg/ddi116
Mathew, 2004, Fat, fiber, fruits, vegetables, and risk of colorectal adenomas, Int J Cancer, 108, 287, 10.1002/ijc.10984
Reddy, 2003, Natural products for cancer prevention: a global perspective, Pharmacol Ther, 99, 1, 10.1016/S0163-7258(03)00042-1
Block, 1992, Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence, Nutr Cancer, 18, 1, 10.1080/01635589209514201
Steinmetz, 1996, Vegetables, fruit, and cancer prevention: a review, J Am Diet Assoc, 96, 1027, 10.1016/S0002-8223(96)00273-8
Aggarwal, 2004, Nuclear factor-kappaB: the enemy within, Cancer Cell, 6, 203, 10.1016/j.ccr.2004.09.003
Singh, 1995, Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected], J Biol Chem, 270, 24995, 10.1074/jbc.270.42.24995
Manna, 2000, Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation, J Immunol, 164, 6509, 10.4049/jimmunol.164.12.6509
Shishodia, 2004, Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis, J Biol Chem, 279, 47148, 10.1074/jbc.M408093200
Shishodia, 2003, Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1, Cancer Res, 63, 4375
Takada, 2003, Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9, J Immunol, 171, 3278, 10.4049/jimmunol.171.6.3278
Kumar, 1998, Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells, Oncogene, 17, 913, 10.1038/sj.onc.1201998
Kim, 2004, Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin, Biofactors, 21, 27, 10.1002/biof.552210107
Takada, 2004, Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9, J Biol Chem, 279, 4750, 10.1074/jbc.M304546200
Takada, 2005, Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion, Oncogene, 24, 6957, 10.1038/sj.onc.1208845
Takada, 2005, Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion, J Biol Chem, 280, 17203, 10.1074/jbc.M500077200
Takada, 2005, Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells, Blood, 106, 641, 10.1182/blood-2004-12-4589
Chainy, 2000, Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis, Oncogene, 19, 2943, 10.1038/sj.onc.1203614
Yang, 2001, The green tea polyphenol (−)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6, Mol Pharmacol, 60, 528
Geng, 1997, S-Allyl cysteine inhibits activation of nuclear factor kappa B in human T cells, Free Radic Biol Med, 23, 345, 10.1016/S0891-5849(97)00006-3
Kim, 2004, Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB, Immunology, 113, 203, 10.1111/j.1365-2567.2004.01945.x
Shishodia, 2005, Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IkappaB kinase activation and NF-kappaB-regulated gene expression, Oncogene
Shishodia, 2005, Curcumin: getting back to the roots, Ann NY Acad Sci, 1056, 206, 10.1196/annals.1352.010
Natarajan, 1996, Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B, Proc Natl Acad Sci USA, 93, 9090, 10.1073/pnas.93.17.9090
Chaturvedi, 1997, Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation, J Biol Chem, 272, 30129, 10.1074/jbc.272.48.30129
Bohmann, 1987, Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1, Science, 238, 1386, 10.1126/science.2825349
Dong, 2000, Effects of food factors on signal transduction pathways, Biofactors, 12, 17, 10.1002/biof.5520120104
Lagarrigue, 1995, Suppression of oncogene-induced transformation by quercetin and retinoic acid in rat liver epithelial cells, Cell Mol Biol Res, 41, 551
Han, 2002, Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells, J Biochem Mol Biol, 35, 337, 10.5483/BMBRep.2002.35.3.337
Hergenhahn, 2002, The chemopreventive compound curcumin is an efficient inhibitor of Epstein–Barr virus BZLF1 transcription in Raji DR-LUC cells, Mol Carcinogen, 33, 137, 10.1002/mc.10029
Han, 2001, Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis, Cancer Lett, 164, 119, 10.1016/S0304-3835(01)00378-0
Manna, 2000, Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase, Cancer Res, 60, 3838
Manna, 1999, Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone, Biochem Pharmacol, 57, 763, 10.1016/S0006-2952(98)00354-2
Chen, 1999, Inhibition of ultraviolet B-induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (−)-epigallocatechin gallate in a human keratinocyte cell line, Mol Carcinogen, 24, 79, 10.1002/(SICI)1098-2744(199902)24:2<79::AID-MC1>3.0.CO;2-E
Chung, 2001, Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (−)-epigallocatechin-3-gallate and theaflavin-3,3′-digallate, FASEB J, 15, 2022, 10.1096/fj.01-0031fje
Yang, 2000, Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction, Carcinogenesis, 21, 2035, 10.1093/carcin/21.11.2035
Balasubramanian, 2002, Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes, J Biol Chem, 277, 1828, 10.1074/jbc.M110376200
Wadsworth, 2001, Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha, Biochem Pharmacol, 62, 963, 10.1016/S0006-2952(01)00734-1
Mukhopadhyay, 2001, Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines, Oncogene, 20, 7597, 10.1038/sj.onc.1204997
Nakamura, 2002, Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines, Int J Oncol, 21, 825
Ichiki, 2000, Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer, Clin Exp Metastasis, 18, 539, 10.1023/A:1011980313237
Kang, 2004, Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells, J Pharmacol Sci, 94, 325, 10.1254/jphs.94.325
Baldin, 1993, Cyclin D1 is a nuclear protein required for cell cycle progression in G1, Genes Dev, 7, 812, 10.1101/gad.7.5.812
Mukhopadhyay, 2002, Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation, Oncogene, 21, 8852, 10.1038/sj.onc.1206048
Estrov, 2003, Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells, Blood, 102, 987, 10.1182/blood-2002-11-3550
Li, 2005, Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels, Cancer Res, 65, 8200, 10.1158/0008-5472.CAN-05-1302
Jakubikova, 2005, Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines, Anticancer Res, 25, 3375
Takagaki, 2005, Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway, Int J Oncol, 26, 185
Tyagi, 2002, Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis, Clin Cancer Res, 8, 3512
Bartkova, 1994, Cyclin D1 protein expression and function in human breast cancer, Int J Cancer, 57, 353, 10.1002/ijc.2910570311
Adelaide, 1995, Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1, Br J Cancer, 71, 64, 10.1038/bjc.1995.13
Caputi, 1999, Prognostic role of cyclin D1 in lung cancer. Relationship to proliferating cell nuclear antigen, Am J Respir Cell Mol Biol, 20, 746, 10.1165/ajrcmb.20.4.3366
Nishida, 1994, Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma, Cancer Res, 54, 3107
Gumbiner, 1999, Overexpression of cyclin D1 is rare in human prostate carcinoma, Prostate, 38, 40, 10.1002/(SICI)1097-0045(19990101)38:1<40::AID-PROS5>3.0.CO;2-I
Bharti, 2003, Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis, Blood, 101, 1053, 10.1182/blood-2002-05-1320
Park, 2002, Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53, Int J Oncol, 21, 379
Chaudhary, 2003, Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells, J Cell Biochem, 89, 1, 10.1002/jcb.10495
Ahmad, 2001, Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells, Clin Cancer Res, 7, 1466
Hsieh, 1999, Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2, Cancer Res, 59, 2596
Liang, 2003, Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells, Biochem Pharmacol, 65, 1053, 10.1016/S0006-2952(03)00011-X
Wolter, 2001, Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines, J Nutr, 131, 2197, 10.1093/jn/131.8.2197
Gupta, 2000, Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (−)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells, Toxicol Appl Pharmacol, 164, 82, 10.1006/taap.1999.8885
Surh, 2003, Cancer chemoprevention with dietary phytochemicals, Nat Rev Cancer, 3, 768, 10.1038/nrc1189
Bharti, 2002, Nuclear factor-kappa B and cancer: its role in prevention and therapy, Biochem Pharmacol, 64, 883, 10.1016/S0006-2952(02)01154-1
Anto, 2002, Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl, Carcinogenesis, 23, 143, 10.1093/carcin/23.1.143
Shishodia, 2005, Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma, Biochem Pharmacol, 70, 700, 10.1016/j.bcp.2005.04.043
Aggarwal, 2004, Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies, Anticancer Res, 24, 2783
Samudio, 2005, Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure, Mol Cancer Ther, 4, 1982, 10.1158/1535-7163.MCT-05-0247
Chen, 2003, Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells, Carcinogenesis, 24, 1369, 10.1093/carcin/bgg091
Hastak, 2003, Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells, Oncogene, 22, 4851, 10.1038/sj.onc.1206708
Kuo, 2003, Green tea constituent (−)-epigallocatechin-3-gallate inhibits Hep G2 cell proliferation and induces apoptosis through p53-dependent and Fas-mediated pathways, J Biomed Sci, 10, 219
Kuo, 1998, Apoptosis and hepatic allograft reperfusion injury, Clin Transplant, 12, 219
Bode, 2001, Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol, Cancer Res, 61, 850
Keum, 2002, Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells, Cancer Lett, 177, 41, 10.1016/S0304-3835(01)00781-9
Miyoshi, 2003, Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in human T lymphoma Jurkat cells, Cancer Lett, 199, 113, 10.1016/S0304-3835(03)00381-1
Alessi, 1996, Mechanism of activation of protein kinase B by insulin and IGF-1, EMBO J, 15, 6541, 10.1002/j.1460-2075.1996.tb01045.x
Clarke, 2003, p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis, Breast Cancer Res, 5, 162, 10.1186/bcr596
Chang, 2003, Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy, Leukemia, 17, 590, 10.1038/sj.leu.2402824
Ozes, 1999, NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase, Nature, 401, 82, 10.1038/43466
Romashkova, 1999, NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling, Nature, 401, 86, 10.1038/43474
Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4
Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science, 282, 1318, 10.1126/science.282.5392.1318
Rommel, 1999, Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt, Science, 286, 1738, 10.1126/science.286.5445.1738
Li, 2002, Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway, Clin Cancer Res, 8, 2369
Chinni, 2002, Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells, Clin Cancer Res, 8, 1228
Aggarwal, 2006, Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of I{kappa}B{alpha} kinase and Akt activation, Mol Pharmacol, 69, 195, 10.1124/mol.105.017400
Tang, 2003, Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of Akt molecule, Int J Cancer, 106, 871, 10.1002/ijc.11325
Huang, 2006, Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway, Cancer Res, 66, 581, 10.1158/0008-5472.CAN-05-1951
Squires, 2003, Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells, Biochem Pharmacol, 65, 361, 10.1016/S0006-2952(02)01517-4
Woo, 2003, Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt, Carcinogenesis, 24, 1199, 10.1093/carcin/bgg082
Masuda, 2002, Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction, J Exp Ther Oncol, 2, 350, 10.1046/j.1359-4117.2002.01062.x
el-Deiry, 1993, WAF1, a potential mediator of p53 tumor suppression, Cell, 75, 817, 10.1016/0092-8674(93)90500-P
Han, 1999, Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53, Clin Immunol, 93, 152, 10.1006/clim.1999.4769
Huang, 1999, Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway, Carcinogenesis, 20, 237, 10.1093/carcin/20.2.237
Hong, 2002, 3,3′-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression, Carcinogenesis, 23, 1297, 10.1093/carcin/23.8.1297
Gu, 2005, Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin, Carcinogenesis, 26, 1404, 10.1093/carcin/bgi096
Bush, 2001, Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53, Exp Cell Res, 271, 305, 10.1006/excr.2001.5381
Choudhuri, 2002, Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction, FEBS Lett, 512, 334, 10.1016/S0014-5793(02)02292-5
Choudhuri, 2005, Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner, J Biol Chem, 280, 20059, 10.1074/jbc.M410670200
Liontas, 2004, Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma, Anticancer Res, 24, 987
She, 2001, Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase, Cancer Res, 61, 1604
Shih, 2002, Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism, J Clin Endocrinol Metabol, 87, 1223, 10.1210/jcem.87.3.8345
Baek, 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53, Carcinogenesis, 23, 425, 10.1093/carcin/23.3.425
Nachshon-Kedmi, 2003, Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells, Food Chem Toxicol, 41, 745, 10.1016/S0278-6915(03)00004-8
Korutla, 1995, Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin, Carcinogenesis, 16, 1741, 10.1093/carcin/16.8.1741
Hong, 1999, Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu, Clin Cancer Res, 5, 1884
Wang, 2001, Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation, J Neuroimmunol, 112, 28, 10.1016/S0165-5728(00)00374-X
Zhong, 1999, Inhibitory effect of resveratrol on interleukin 6 release by stimulated peritoneal macrophages of mice, Phytomedicine, 6, 79, 10.1016/S0944-7113(99)80039-7
Shen, 2003, Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells, J Asian Natl Prod Res, 5, 151, 10.1080/1028602031000066852
Kaneuchi, 2003, Resveratrol suppresses growth of Ishikawa cells through down-regulation of EGF, Int J Oncol, 23, 1167
Xia, 2005, UV-induced NF-kappaB activation and expression of IL-6 is attenuated by (−)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro, Int J Mol Med, 16, 943
Chen, 2002, A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium, Inflammation, 26, 233, 10.1023/A:1019718718977
Basini, 2005, EGCG, a major component of green tea, inhibits VEGF production by swine granulosa cells, Biofactors, 23, 25, 10.1002/biof.5520230104
Waleh, 2005, Novel D-ring analog of epigallocatechin-3-gallate inhibits tumor growth and VEGF expression in breast carcinoma cells, Anticancer Res, 25, 397
Masamune, 2005, Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells, World J Gastroenterol, 11, 3368, 10.3748/wjg.v11.i22.3368
Weber, 2004, Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis, FASEB J, 18, 128, 10.1096/fj.03-0007fje
Shimizu, 2005, (−)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells, Clin Cancer Res, 11, 2735, 10.1158/1078-0432.CCR-04-2014
Sah, 2004, Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases, J Biol Chem, 279, 12755, 10.1074/jbc.M312333200
Sartippour, 2002, Inhibition of fibroblast growth factors by green tea, Int J Oncol, 21, 487
Ludwig, 2004, The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells, Biochem Biophys Res Commun, 316, 659, 10.1016/j.bbrc.2004.02.099
Masuda, 2003, Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells, Clin Cancer Res, 9, 3486
Koch, 1992, Interleukin-8 as a macrophage-derived mediator of angiogenesis, Science, 258, 1798, 10.1126/science.1281554
Hidaka, 2002, Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface: impact on human pancreatic carcinoma cell growth by autocrine regulation, Cancer, 95, 1206, 10.1002/cncr.10812
Ishikawa, 1999, Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB, J Am Soc Nephrol, 10, 2290, 10.1681/ASN.V10112290
Porath, 2005, Epigallocatechin-3-gallate impairs chemokine production in human colon epithelial cell lines, J Pharmacol Exp Ther, 315, 1172, 10.1124/jpet.105.090167
Aneja, 2004, Theaflavin, a black tea extract, is a novel anti-inflammatory compound, Crit Care Med, 32, 2097, 10.1097/01.CCM.0000142661.73633.15
Rimbach, 2004, Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function, Biochim Biophys Acta, 1670, 229, 10.1016/j.bbagen.2003.12.008
Patel, 2002, Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation, J Interferon Cytokine Res, 22, 427, 10.1089/10799900252952217
Nakayama, 2001, Unexpected transcriptional induction of monocyte chemoattractant protein 1 by proteasome inhibition: involvement of the c-Jun N-terminal kinase-activator protein 1 pathway, J Immunol, 167, 1145, 10.4049/jimmunol.167.3.1145
Xu, 1997, Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells, Exp Hematol, 25, 413
Kang, 2005, Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages, Cancer Lett, 230, 219, 10.1016/j.canlet.2004.12.041
Takano, 2004, Inhibitory effect of (−)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo, J Agric Food Chem, 52, 4571, 10.1021/jf0355194
Aggarwal, 2003, Signalling pathways of the TNF superfamily: a double-edged sword, Nat Rev Immunol, 3, 745, 10.1038/nri1184
Moore, 1999, Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis, Nat Med, 5, 828, 10.1038/10462
Sugarman, 1985, Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro, Science, 230, 943, 10.1126/science.3933111
Giri, 1998, Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates, J Biol Chem, 273, 14008, 10.1074/jbc.273.22.14008
Aggarwal, 1996, Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells, Cancer Res, 56, 5156
Tucker, 2004, Switching leukemia cell phenotype between life and death, Proc Natl Acad Sci USA, 101, 12940, 10.1073/pnas.0400949101
Estrov, 1993, Lymphotoxin is an autocrine growth factor for Epstein–Barr virus-infected B cell lines, J Exp Med, 177, 763, 10.1084/jem.177.3.763
Sugarman, 1987, Effects of growth factors on the antiproliferative activity of tumor necrosis factors, Cancer Res, 47, 780
Chapekar, 1989, Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor beta 1, and recombinant tumor necrosis factor alpha, in normal and neoplastic cells, Exp Cell Res, 185, 247, 10.1016/0014-4827(89)90053-0
Borset, 1994, TNF and IL-6 are potent growth factors for OH-2, a novel human myeloma cell line, Eur J Haematol, 53, 31, 10.1111/j.1600-0609.1994.tb00176.x
Hsu, 1990, Lack of effect of colony-stimulating factors, interleukins, interferons, and tumor necrosis factor on the growth and differentiation of cultured Reed–Sternberg cells. Comparison with effects of phorbol ester and retinoic acid, Am J Pathol, 136, 181
Yang, 1998, Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model, J Nutr, 128, 2334, 10.1093/jn/128.12.2334
Surh, 1999, Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger, J Environ Pathol Toxicol Oncol, 18, 131
Kowalski, 2005, Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages, Pharmacol Rep, 57, 390
Liu, 2005, Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB activation, Planta Med, 71, 808, 10.1055/s-2005-871231
Ishii, 2003, Inhibition of lipopolysaccharide-induced pro-inflammatory cytokine expression via suppression of nuclear factor-kappaB activation by Mallotus japonicus phloroglucinol derivatives, Biochim Biophys Acta, 1620, 108, 10.1016/S0304-4165(02)00514-7
Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455
Yu, 1995, Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein, Science, 269, 81, 10.1126/science.7541555
Bromberg, 1998, Stat3 activation is required for cellular transformation by v-src, Mol Cell Biol, 18, 2553, 10.1128/MCB.18.5.2553
Grandis, 1998, Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro, J Clin Invest, 102, 1385, 10.1172/JCI3785
Carlesso, 1996, Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl, J Exp Med, 183, 811, 10.1084/jem.183.3.811
Weber-Nordt, 1996, Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein–Barr virus (EBV)-related lymphoma cell lines, Blood, 88, 809, 10.1182/blood.V88.3.809.809
Bharti, 2003, Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells, J Immunol, 171, 3863, 10.4049/jimmunol.171.7.3863
Schnyder, 2002, Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1, Biochem Biophys Res Commun, 292, 841, 10.1006/bbrc.2002.6754
Masuda, 2001, Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines, Clin Cancer Res, 7, 4220
Wung, 2005, Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation, Life Sci, 78, 389, 10.1016/j.lfs.2005.04.052
Tedeschi, 2004, Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activation, Mol Pharmacol, 65, 111, 10.1124/mol.65.1.111
Bharti, 2004, Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis, Blood, 103, 3175, 10.1182/blood-2003-06-2151
Kim, 2003, Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia, J Immunol, 171, 6072, 10.4049/jimmunol.171.11.6072
Subbaramaiah, 2003, Cyclooxygenase 2: a molecular target for cancer prevention and treatment, Trends Pharmacol Sci, 24, 96, 10.1016/S0165-6147(02)00043-3
Baumann, 1980, Flavonoids and related compounds as inhibition of arachidonic acid peroxidation, Prostaglandins, 20, 627, 10.1016/0090-6980(80)90103-3
Landolfi, 1984, Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure–activity relations, Biochem Pharmacol, 33, 1525, 10.1016/0006-2952(84)90423-4
Williams, 1999, The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties, Phytochemistry, 51, 417, 10.1016/S0031-9422(99)00021-7
Yasukawa, 1998, 3Beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect, Phytochemistry, 48, 1357, 10.1016/S0031-9422(97)01063-7
Mutoh, 2000, Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure, Carcinogenesis, 21, 959, 10.1093/carcin/21.5.959
Chen, 2001, Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide, Biochem Pharmacol, 61, 1417, 10.1016/S0006-2952(01)00594-9
Gerhauser, 2003, Mechanism-based in vitro screening of potential cancer chemopreventive agents, Mutat Res, 523–524, 163, 10.1016/S0027-5107(02)00332-9
Plummer, 1999, Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex, Oncogene, 18, 6013, 10.1038/sj.onc.1202980
Subbaramaiah, 1998, Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells, J Biol Chem, 273, 21875, 10.1074/jbc.273.34.21875
Kundu, 2003, Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells, J Nutr, 133, 3805S, 10.1093/jn/133.11.3805S
Hong, 2001, Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues, Biochem Pharmacol, 62, 1175, 10.1016/S0006-2952(01)00767-5
Chung, 2003, Anti-inflammatory effect of the oligomeric stilbene alpha-viniferin and its mode of the action through inhibition of cyclooxygenase-2 and inducible nitric oxide synthase, Planta Med, 69, 710, 10.1055/s-2003-42787
Banerjee, 2002, Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9, Cancer Res, 62, 4945
MacCarrone, 1999, Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity, Eur J Biochem, 265, 27, 10.1046/j.1432-1327.1999.00630.x
Hong, 2004, Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase, Carcinogenesis, 25, 1671, 10.1093/carcin/bgh165
Laughton, 1991, Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability, Biochem Pharmacol, 42, 1673, 10.1016/0006-2952(91)90501-U
Reddy, 1991, A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor, Biochem Pharmacol, 41, 115, 10.1016/0006-2952(91)90018-Z
Sekiya, 1982, Selective inhibition of platelet lipoxygenase by baicalein, Biochem Biophys Res Commun, 105, 1090, 10.1016/0006-291X(82)91081-6
Hartisch, 1997, Dual inhibitory activities of tannins from Hamamelis virginiana and related polyphenols on 5-lipoxygenase and lyso-PAF: acetyl-CoA acetyltransferase, Planta Med, 63, 106, 10.1055/s-2006-957623
Kim, 1998, Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells, Cancer Lett, 125, 199, 10.1016/S0304-3835(97)00513-2
Soliman, 1998, In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds, Proc Soc Exp Biol Med, 218, 390, 10.3181/00379727-218-44309
Ippoushi, 2003, [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions, Life Sci, 73, 3427, 10.1016/j.lfs.2003.06.022
Lin, 1997, (−)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB, Mol Pharmacol, 52, 465, 10.1124/mol.52.3.465
Tsai, 1999, Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol, Br J Pharmacol, 126, 673, 10.1038/sj.bjp.0702357
Chen, 2003, Suppression of inducible nitric oxide production by indole and isothiocyanate derivatives from Brassica plants in stimulated macrophages, Planta Med, 69, 696, 10.1055/s-2003-42790
Chen, 2000, Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation, Biochem Pharmacol, 59, 1445, 10.1016/S0006-2952(00)00255-0
Brouet, 1995, Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages, Biochem Biophys Res Commun, 206, 533, 10.1006/bbrc.1995.1076
Rao, 1999, Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor, Carcinogenesis, 20, 641, 10.1093/carcin/20.4.641
Onoda, 2000, Effect of curcumin on the production of nitric oxide by cultured rat mammary gland, Nitric Oxide, 4, 505, 10.1006/niox.2000.0305
Cowley, 1994, Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells, Cell, 77, 841, 10.1016/0092-8674(94)90133-3
Minden, 1994, Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK, Science, 266, 1719, 10.1126/science.7992057
Bode, 2000, Signal transduction pathways: targets for chemoprevention of skin cancer, Lancet Oncol, 1, 181, 10.1016/S1470-2045(00)00029-2
Bode, 2003, Mitogen-activated protein kinase activation in UV-induced signal transduction, Sci STKE, 2003, RE2, 10.1126/stke.2003.167.re2
Kallunki, 1994, JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation, Genes Dev, 8, 2996, 10.1101/gad.8.24.2996
Cho, 2005, Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets, Exp Mol Med, 37, 186, 10.1038/emm.2005.25
Li, 2003, Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis, J Nutr, 133, 1011, 10.1093/jn/133.4.1011
Katiyar, 2001, Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (−)-epigallocatechin-3-gallate, Toxicol Appl Pharmacol, 176, 110, 10.1006/taap.2001.9276
Salh, 2003, Curcumin attenuates DNB-induced murine colitis, Am J Physiol Gastrointest Liver Physiol, 285, G235, 10.1152/ajpgi.00449.2002
Chen, 1998, Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin, Oncogene, 17, 173, 10.1038/sj.onc.1201941
Woo, 2004, Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction, Oncogene, 23, 1845, 10.1038/sj.onc.1207307
Stewart, 2004, Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition, Invest New Drugs, 22, 107, 10.1023/B:DRUG.0000011787.75522.ec
Wang, 2002, The specific anti-cancer activity of green tea (−)-epigallocatechin-3-gallate (EGCG), Amino Acids, 22, 131, 10.1007/s007260200002
Maeda-Yamamoto, 2003, Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells, J Agric Food Chem, 51, 1858, 10.1021/jf021039l
Chen, 2000, Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death, Arch Pharm Res, 23, 605, 10.1007/BF02975249
Deguchi, 2002, Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D, Int J Oncol, 21, 1301
Fang, 2003, Tea polyphenol (−)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines, Cancer Res, 63, 7563
Lee, 2005, Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids, Mol Pharmacol, 68, 1018, 10.1124/mol.104.008367
Mittal, 2003, Exceptionally high protection of photocarcinogenesis by topical application of (−)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylation, Neoplasia, 5, 555, 10.1016/S1476-5586(03)80039-8
Arbiser, 1998, Curcumin is an in vivo inhibitor of angiogenesis, Mol Med, 4, 376, 10.1007/BF03401744
Chen, 2004, Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis, Mol Pharmacol, 65, 99, 10.1124/mol.65.1.99
Brakenhielm, 2001, Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes, FASEB J, 15, 1798, 10.1096/fj.01-0028fje
Shih, 2001, Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression, Growth Factors, 19, 19, 10.3109/08977190109001073
Bagli, 2004, Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity, Cancer Res, 64, 7936, 10.1158/0008-5472.CAN-03-3104
Lamy, 2002, Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation, Cancer Res, 62, 381
Dorai, 2001, Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo, Prostate, 47, 293, 10.1002/pros.1074
Leu, 2003, Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity, Biochem Pharmacol, 66, 2323, 10.1016/j.bcp.2003.08.017
Shim, 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin, Chem Biol, 10, 695, 10.1016/S1074-5521(03)00169-8
Ray, 2003, Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin, J Environ Pathol Toxicol Oncol, 22, 49
Lin, 2003, Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation, Mol Pharmacol, 64, 1029, 10.1124/mol.64.5.1029
Bertelli, 2001, Resveratrol inhibits TNF alpha-induced endothelial cell activation, Therapie, 56, 613