Molecular biology of gallbladder cancer: Potential clinical implications

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Kim, 2008, Tumour Biol, Gene expression profiles in gallbladder cancer: The close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis, 41

Pandey, 2007, Liver Int, Haplotype anal ysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer, 1008

Srivastava, 2009, Liver Int, Single nucleotide polymorphism in the ABCG8 transporter gene is associated with gallbladder cancer susceptibility, 831

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Huang, 2008, Carcinogenesis, Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: A population-based case-control study in China, 100

Kim, 2008, Pathology, Decreased expression of Bax-interacting factor-1 (Bif-1) in invasive urinary bladder and gallbladder cancers, 553

Puhalla, 2005, Anticancer Res, E-cadherin and beta-catenin expression in normal, inflamed and cancerous gallbladder tissue, 4249

Priya, 2010, Virchows Arch, Role of E-cadherin gene in gall bladder cancer and its precursor lesions, 507

Hirata, 2006, Oncology, Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis, 102

Adachi, 2010, Cancer Invest, T-cadherin modulates tumor-associated molecules in gallbladder cancer cells, 120

Adachi, 2009, FEBS Lett, Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer, 430

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Shi, 2010, Cancer Biol Ther, CD44+ CD133+ population exhibits cancer stem cell-like characteristics in human gallbladder carcinoma, 1182

Liu, 2007, Hepatobiliary Pancreat Dis Int, Distribution of natural killer cells and T-lymphocyte subsets in peripheral blood, gallbladder cancer and surrounding tissue, 81

Liu, 2011, Pathol Oncol Res, Clinicopathologic and prognostic significance of CD24 in gallbladder carcinoma, 45

Ai, 2011, Cancer Lett, Arsenic oxide targets stem cell marker CD133/prominin-1 in gallbladder carcinoma, 181

Wu, 2009, Med Oncol, Prediction of prognosis in gallbladder carcinoma by CD147 and MMP-2 immunohistochemistry, 117

Li, 2011, Pathol Oncol Res, Expression of CDX2 and hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic type and clinical outcome, 561

Wani, 2008, Virchows Arch, Aberrant expression of an "intestinal marker" Cdx2 in pyloric gland adenoma of the gallbladder, 521

Chang, 2007, J Gastroenterol Hepatol, Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma, 389

Chaube, 2006, BMC Cancer, Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients, 126

Zong, 2009, Tohoku J Exp Med, Over-expression of c-FLIP confers the resistance to TRAIL-induced apoptosis on gallbladder carcinoma, 203

Wang, 2009, Cancer Lett, Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1, 71

Saito, 2006, Oncol Rep, The genetic differences between gallbladder and bile duct cancer cell lines, 949

Vishnoi, 2008, Hum Immunol, Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer, 360

Sergeant, 2011, Eur J Surg Oncol, The prognostic relevance of tumor hypoxia markers in resected carcinoma of the gallbladder, 80

Tewari, 2008, World J Surg, Is there a role for cholecystectomy in gallbladder carcinoma discovered to be unresectable for cure at laparotomy?, 2683

Pignochino, 2010, BMC Cancer, Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas, 631

Shafizadeh, 2010, Hum Pathol, Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder, 485

Leone, 2006, Clin Cancer Res, Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma, 1680

Hsing, 2008, Cancer Res, Variants in inflammation genes and the risk of biliary tract cancers and stones: A population-based study in China, 6442

Jia, 2011, Oncol Rep, mda-7/IL-24 induces apoptosis in human GBC-SD gallbladder carcinoma cells via mitochondrial apoptotic pathway, 195

Vishnoi, 2008, Cancer Genet Cytogenet, IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population, 63

Lynch, 2008, Ann Diagn Pathol, Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder, 161

Kim, 2009, Ann Surg Oncol, Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer, 23

Alsheyab, 2007, Saudi Med J, Expression of p21 and p27 in gallbladder cancer, 683

Li, 2007, Mod Pathol, Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: An immunohistochemical study of 62 cases by tissue microarray, 497

Rai, 2011, Eur J Cancer Prev, p53: Its alteration and gallbladder cancer, 77

Nigam, 2010, Trop Gastroenterol, Alterations of p53 gene in gallbladder cancer patients of North India, 96

Castillo, 2010, Rev Med Chil, Genetic alterations in preneoplastic and neoplastic injuries of the gallbladder, 595

Wang, 2006, Kaohsiung J Med Sci, Aberrant p53 expression and the development of gallbladder carcinoma and adenoma, 53

Arévalo, 2007, Rev Esp Enferm Dig, Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder, 694

Nagahashi, 2008, World J Gastroenterol, Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary, 70

Takagawa, 2005, Dig Dis Sci, Prediction of prognosis in gallbladder carcinoma by mucin and p53 immunohistochemistry, 1410

Chang, 2007, Pathol Oncol Res, Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas, 326

Mishra, 2000, Genet Mol Res, Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas, 1202

Yanagisawa, 2010, Anticancer Res, Sporadic TP53 transition mutations in chronic cholecystitis are possibly linked to gallbladder carcinogenesis, 4443

Moreno, 2005, Ann Hepatol, TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma, 192

Deshpande, 2011, BMC Cancer, Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma, 60

García, 2009, Mol Carcinog, Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions, 79

Roa, 2006, J Gastroenterol, Promoter methylation profile in gallbladder cancer, 269

Lee, 2006, Cancer Sci, Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features, 1205

Tan, 2010, Zhonghua Zhong Liu Za Zhi, Comparative proteomic analysis of human gallbladder carcinoma, 29

Kim, 2010, Hum Pathol, Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma, 1609

Kee, 2007, Mol Cells, Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer, 364

Tamura, 2009, Hum Pathol, Reg IV expression and clinicopathologic features of gallbladder carcinoma, 1686

Chen, 2011, APMIS, Rsf-1/HBXAP overexpression is associated with disease-specific survival of patients with gallbladder carcinoma, 808

Liu, 2011, Mol Oncol, Inhibitory effect of survivin promoter-regulated oncolytic adenovirus carrying p53 gene against gallbladder cancer, 545

Roh, 2008, Eur Surg Res, Syndecan-1 expression in gallbladder cancer and its prognostic significance, 245

Han, 2012, Front Biosci, SNCG gene silencing in gallbladder cancer cells inhibits key tumorigenic activities, 1589

Ouyang, 2010, Surg Oncol, Immunoreactivity and prognostic value of tumor-associated glycoprotein 72 in primary gallbladder carcinoma, 82

Hansel, 2006, Mod Pathol, Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma, 772

Shukla, 2006, Anticancer Res, Telomerase activation - one step on the road to carcinoma of the gall bladder, 4761

Maurya, 2011, Asian Pac J Cancer Prev, Expression pattern of tumor endothelial marker 8 protein in gallbladder carcinomas, 507

Roh, 2009, J Hepatobiliary Pancreat Surg, Fascin overexpression correlates with positive thrombospondin-1 and syndecan-1 expressions and a more aggressive clinical course in patients with gallbladder cancer, 315

Won, 2010, BMC Cancer, Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer, 564

Harino, 2008, Int J Clin Oncol, Role of tumor angiogenesis in gallbladder carcinoma: With special reference to thymidine phosphorylase, 452

Vishnoi, 2007, Asian Pac J Cancer Prev, Do TNFA -308G/A and IL6-174G/C gene polymorphisms modulate risk of gallbladder cancer in the north Indian population?, 567

Srivastava, 2010, Liver Int, Significant association between toll-like receptor gene polymorphisms and gallbladder cancer, 1067

Washiro, 2008, J Cancer Res Clin Oncol, Upregulation of topoisomerase IIalpha expression in advanced gallbladder carcinoma: A potential chemotherapeutic target, 793

Sun, 2011, J Exp Clin Cancer Res, A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitro, 46

Chen, 2010, Mol Cell Biochem, Vascular endothelial growth factor-C promotes the growth and invasion of gallbladder cancer via an autocrine mechanism, 77

Jiang, 2010, Zhonghua Zhong Liu Za Zhi, Expressions of VEGF-C and VEGF-D and their correlation with lymphangiogenesis and angiogenesis in gallbladder carcinoma, 190

Lin, 2012, Cancer Lett, Vascular endothelial growth factor-D promotes growth, lymphangiogenesis and lymphatic metastasis in gallbladder cancer, 127

Jiao, 2011, Carcinogenesis, Ala499Val (C>T) and Lys939Gln (A>C) polymorphisms of the XPC gene: Their correlation with the risk of primary gallbladder adenocarcinoma - a case-control study in China, 496