Đa dạng phân tử của thụ thể glutamate và ứng dụng cho chức năng não bộ

American Association for the Advancement of Science (AAAS) - Tập 258 Số 5082 - Trang 597-603 - 1992
Shigetada Nakanishi1
1Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

Tóm tắt

\n Các thụ thể glutamate đóng vai trò trung gian trong quá trình dẫn truyền thần kinh kích thích trong não bộ và rất quan trọng trong sự tiếp thu trí nhớ, học tập và một số rối loạn thần kinh thoái hóa. Gia đình thụ thể này được phân loại thành ba nhóm: thụ thể \n N\n -methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate, và thụ thể metabotropic. Các nghiên cứu phân tử gần đây đã chỉ ra rằng có nhiều phân nhóm thụ thể tồn tại trong cả ba nhóm và biểu hiện sự không đồng nhất về chức năng và mẫu biểu hiện. Bài báo này tổng quan đa dạng phân tử và chức năng của thụ thể glutamate và thảo luận về tác động của chúng đối với chức năng tổng hợp của não bộ.\n

Từ khóa

#glutamate receptors #neurotransmission #memory acquisition #neurodegenerative disorders #molecular diversity #brain function

Tài liệu tham khảo

ABE, T, MOLECULAR CHARACTERIZATION OF A NOVEL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COUPLED TO INOSITOL PHOSPHATE/CA2+ SIGNAL TRANSDUCTION, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 13361 (1992).

ARAMORI, I, SIGNAL TRANSDUCTION AND PHARMACOLOGICAL CHARACTERISTICS OF A METABOTROPIC GLUTAMATE RECEPTOR, MGLUR1, IN TRANSFECTED CHO CELLS, NEURON 8: 757 (1992).

BARNARD, E.A., TRANSLATION OF EXOGENOUS MESSENGER-RNA CODING FOR NICOTINIC ACETYLCHOLINE-RECEPTORS PRODUCES FUNCTIONAL RECEPTORS IN XENOPUS OOCYTES, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 215: 241 (1982).

BASKYS, A, JOURNAL OF PHYSIOLOGY-LONDON 444: 687 (1991).

BASKYS, A, METABOTROPIC RECEPTORS AND SLOW EXCITATORY ACTIONS OF GLUTAMATE AGONISTS IN THE HIPPOCAMPUS, TRENDS IN NEUROSCIENCES 15: 92 (1992).

Bessho, Y., Journal of Neurochemistry 60: 253 (1993).

BETTLER, B, CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT, NEURON 5: 583 (1990).

10.1126/science.2168579

10.1126/science.1317970

10.1126/science.1382314

COLLINGRIDGE, G.L., NMDA RECEPTORS - THEIR ROLE IN LONG-TERM POTENTIATION, TRENDS IN NEUROSCIENCES 10: 288 (1987).

DINGLEDINE, R, NEW WAVE OF NON-NMDA EXCITATORY AMINO-ACID RECEPTORS, TRENDS IN PHARMACOLOGICAL SCIENCES 12: 360 (1991).

FORSYTHE, I. D., JOURNAL OF PHYSIOLOGY 429: 1 (1990).

10.1126/science.1849316

GONZALES, R.A., BIOCHEMICAL RESPONSES MEDIATED BY N-METHYL-D-ASPARTATE RECEPTORS IN RAT CORTICAL SLICES ARE DIFFERENTIALLY SENSITIVE TO MAGNESIUM, JOURNAL OF NEUROCHEMISTRY 58: 579 (1992).

Hayashi, Y., British Journal of Pharmacology 107: 539 (1992).

HERB, A, THE KA-2 SUBUNIT OF EXCITATORY AMINO-ACID RECEPTORS SHOWS WIDESPREAD EXPRESSION IN BRAIN AND FORMS ION CHANNELS WITH DISTANTLY RELATED SUBUNITS, NEURON 8: 775 (1992).

10.1038/342643a0

10.1126/science.1709304

HONORE, T, EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION 172: 239 (1989).

10.1126/science.1656524

10.1126/science.1653450

10.1113/jphysiol.1990.sp018060

IKIN, A.F., N-METHYL-D-ASPARTATE PHENCYCLIDINE RECEPTOR COMPLEX OF RAT FOREBRAIN - PURIFICATION AND BIOCHEMICAL-CHARACTERIZATION, BIOCHEMISTRY 29: 2290 (1990).

IMOTO, K, A RING OF UNCHARGED POLAR AMINO-ACIDS AS A COMPONENT OF CHANNEL CONSTRICTION IN THE NICOTINIC ACETYLCHOLINE-RECEPTOR, FEBS LETTERS 289: 193 (1991).

10.1038/335645a0

ISHIDA, M, A POTENT METABOTROPIC GLUTAMATE RECEPTOR AGONIST - ELECTROPHYSIOLOGICAL ACTIONS OF A CONFORMATIONALLY RESTRICTED GLUTAMATE ANALOG IN THE RAT SPINAL-CORD AND XENOPUS OOCYTES, BRAIN RESEARCH 537: 311 (1990).

ISHII T unpublished data.

ITO, M, LONG-TERM DEPRESSION, ANNUAL REVIEW OF NEUROSCIENCE 12: 85 (1989).

10.1126/science.3399891

KARP S unpublished data.

10.1126/science.2166337

KUMAR, K.N., CLONING OF CDNA FOR THE GLUTAMATE-BINDING SUBUNIT OF AN NMDA RECEPTOR COMPLEX, NATURE 354: 70 (1991).

10.1038/358036a0

LINDEN, D.J., A LONG-TERM DEPRESSION OF AMPA CURRENTS IN CULTURED CEREBELLAR PURKINJE NEURONS, NEURON 7: 81 (1991).

LY, A.M., SOLUBILIZATION, PARTIAL-PURIFICATION, AND RECONSTITUTION OF GLUTAMATE-ACTIVATED AND N-METHYL-D-ASPARTATE-ACTIVATED CATION CHANNELS FROM BRAIN SYNAPTIC-MEMBRANES, BIOCHEMISTRY 30: 4307 (1991).

10.1146/annurev.ne.14.030191.002115

MASU, M, SEQUENCE AND EXPRESSION OF A METABOTROPIC GLUTAMATE RECEPTOR, NATURE 349: 760 (1991).

MASU, Y, CDNA CLONING OF BOVINE SUBSTANCE-K RECEPTOR THROUGH OOCYTE EXPRESSION SYSTEM, NATURE 329: 836 (1987).

MEGURO, H, FUNCTIONAL-CHARACTERIZATION OF A HETEROMERIC NMDA RECEPTOR CHANNEL EXPRESSED FROM CLONED CDNAS, NATURE 357: 70 (1992).

MELDRUM, B, EXCITATORY AMINO-ACID NEUROTOXICITY AND NEURODEGENERATIVE DISEASE, TRENDS IN PHARMACOLOGICAL SCIENCES 11: 379 (1990).

MILLER, R.J., THE REVENGE OF THE KAINATE RECEPTOR, TRENDS IN NEUROSCIENCES 14: 477 (1991).

MILLER, R.J., METABOTROPIC EXCITATORY AMINO-ACID RECEPTORS REVEAL THEIR TRUE COLORS, TRENDS IN PHARMACOLOGICAL SCIENCES 12: 365 (1991).

10.1146/annurev.pa.29.040189.002053

MONAGHAN, D.T., DIFFERENTIAL STIMULATION OF [H-3] MK-801 BINDING TO SUBPOPULATIONS OF NMDA RECEPTORS, NEUROSCIENCE LETTERS 122: 21 (1991).

MONAGHAN, D.T., 2 CLASSES OF N-METHYL-D-ASPARTATE RECOGNITION SITES - DIFFERENTIAL DISTRIBUTION AND DIFFERENTIAL REGULATION BY GLYCINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 9836 (1988).

MONYER, H, GLUTAMATE-OPERATED CHANNELS - DEVELOPMENTALLY EARLY AND MATURE FORMS ARISE BY ALTERNATIVE SPLICING, NEURON 6: 799 (1991).

10.1126/science.256.5060.1217

MORI, H, IDENTIFICATION BY MUTAGENESIS OF A MG2+-BLOCK SITE OF THE NMDA RECEPTOR CHANNEL, NATURE 358: 673 (1992).

MORIYOSHI, K, MOLECULAR-CLONING AND CHARACTERIZATION OF THE RAT NMDA RECEPTOR, NATURE 354: 31 (1991).

10.1126/science.1317969

NAKAJIMA Y unpublished data.

10.1016/0896-6273(90)90212-X

NAWY, S, SUPPRESSION BY GLUTAMATE OF CGMP-ACTIVATED CONDUCTANCE IN RETINAL BIPOLAR CELLS, NATURE 346: 269 (1990).

NUMA, S, A MOLECULAR VIEW OF NEUROTRANSMITTER RECEPTORS AND IONIC CHANNELS, HARVEY LECTURES 83: 121 (1989).

SAKIMURA, K, FUNCTIONAL EXPRESSION FROM CLONED CDNAS OF GLUTAMATE RECEPTOR SPECIES RESPONSIVE TO KAINATE AND QUISQUALATE, FEBS LETTERS 272: 73 (1990).

SAKIMURA, K, PRIMARY STRUCTURE AND EXPRESSION OF THE GAMMA-2 SUBUNIT OF THE GLUTAMATE RECEPTOR CHANNEL SELECTIVE FOR KAINATE, NEURON 8: 267 (1992).

Sakurada, K., Journal of Biological Chemistry 268: 410 (1993).

SCHOEPP, D, PHARMACOLOGICAL AND FUNCTIONAL-CHARACTERISTICS OF METABOTROPIC EXCITATORY AMINO-ACID RECEPTORS, TRENDS IN PHARMACOLOGICAL SCIENCES 11: 508 (1990).

SHIGEMOTO, R, DISTRIBUTION OF THE MESSENGER-RNA FOR A METABOTROPIC GLUTAMATE RECEPTOR (MGLUR1) IN THE CENTRAL-NERVOUS-SYSTEM - AN INSITU HYBRIDIZATION STUDY IN ADULT AND DEVELOPING RAT, JOURNAL OF COMPARATIVE NEUROLOGY 322: 121 (1992).

SHINOZAKI, H, POTENT NMDA-LIKE ACTIONS AND POTENTIATION OF GLUTAMATE RESPONSES BY CONFORMATIONAL VARIANTS OF A GLUTAMATE ANALOG IN THE RAT SPINAL-CORD, BRITISH JOURNAL OF PHARMACOLOGY 98: 1213 (1989).

10.1016/0092-8674(91)90568-J

10.1126/science.1699275

SONDERS, M.S., A NOVEL PHOTOAFFINITY LIGAND FOR THE PHENCYCLIDINE SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR LABELS A MR 120,000 POLYPEPTIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 6776 (1990).

SUGIHARA, H, STRUCTURES AND PROPERTIES OF 7 ISOFORMS OF THE NMDA RECEPTOR GENERATED BY ALTERNATIVE SPLICING, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 185: 826 (1992).

TANABE, Y, A FAMILY OF METABOTROPIC GLUTAMATE RECEPTORS, NEURON 8: 169 (1992).

TANABE Y unpublished data.

UNWIN, N, THE STRUCTURE OF ION CHANNELS IN MEMBRANES OF EXCITABLE CELLS, NEURON 3: 665 (1989).

10.1126/science.1710829

WATKINS, J.C., STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE DEVELOPMENT OF EXCITATORY AMINO-ACID RECEPTOR AGONISTS AND COMPETITIVE ANTAGONISTS, TRENDS IN PHARMACOLOGICAL SCIENCES 11: 25 (1990).

WERNER, P, CLONING OF A PUTATIVE HIGH-AFFINITY KAINATE RECEPTOR EXPRESSED PREDOMINANTLY IN HIPPOCAMPAL CA3 CELLS, NATURE 351: 742 (1991).

YAMAMOTO, C, INHIBITORY ACTION OF GLUTAMIC-ACID ON CEREBELLAR INTERNEURONES, NATURE 262: 786 (1976).

YAMAZAKI, M, CLONING, EXPRESSION AND MODULATION OF A MOUSE NMDA RECEPTOR SUBUNIT, FEBS LETTERS 300: 39 (1992).