Modulation of cathelicidin and defensins by histone deacetylase inhibitors: A potential treatment for multi-drug resistant infectious diseases

Peptides - Tập 140 - Trang 170527 - 2021
Adrián Rodríguez-Carlos1, Yolanda M. Jacobo-Delgado1, Alan O. Santos-Mena1, Bruno Rivas-Santiago1
1Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico

Tài liệu tham khảo

w.h. organization, 2020 Portela, 2010, Epigenetic modifications and human disease, Nat. Biotechnol., 28, 1057, 10.1038/nbt.1685 Arrowsmith, 2012, Epigenetic protein families: a new frontier for drug discovery, Nat. Rev. Drug Discov., 11, 384, 10.1038/nrd3674 Haberland, 2009, The many roles of histone deacetylases in development and physiology: implications for disease and therapy, Nat. Rev. Genet., 10, 32, 10.1038/nrg2485 Lewies, 2019, Antimicrobial peptides: the Achilles’ heel of antibiotic resistance?, Probiotics Antimicrob. Proteins, 11, 370, 10.1007/s12602-018-9465-0 Rivas-Santiago, 2009, Susceptibility to infectious diseases based on antimicrobial peptide production, Infect. Immun., 77, 4690, 10.1128/IAI.01515-08 Gordon, 2005, A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs, Curr. Eye Res., 30, 505, 10.1080/02713680590968637 Fischer, 2020, Infection-induced epigenetic changes and their impact on the pathogenesis of diseases, Semin. Immunopathol., 42, 127, 10.1007/s00281-020-00793-1 Dabirian, 2013, Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate, PLoS Negl. Trop. Dis., 7, e2491, 10.1371/journal.pntd.0002491 Thiagarajan, 2016, Mechanisms of transcription factor acetylation and consequences in hearts, Biochim. Biophys. Acta, 1862, 2221, 10.1016/j.bbadis.2016.08.011 Gong, 2013, Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation, Mutat. Res., 750, 23, 10.1016/j.mrfmmm.2013.07.002 Chen, 2002, Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB, EMBO J., 21, 6539, 10.1093/emboj/cdf660 Geng, 2012, HIF1α protein stability is increased by acetylation at lysine 709, J. Biol. Chem., 287, 35496, 10.1074/jbc.M112.400697 Zhang, 2018, Zinc binding groups for histone deacetylase inhibitors, J. Enzyme Inhib. Med. Chem., 33, 714, 10.1080/14756366.2017.1417274 Yang, 2015, Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer, Oncotarget, 6, 30263, 10.18632/oncotarget.4749 Ashburner, 2001, The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression, Mol. Cell. Biol., 21, 7065, 10.1128/MCB.21.20.7065-7077.2001 Zhong, 2002, The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1, Mol. Cell, 9, 625, 10.1016/S1097-2765(02)00477-X Villagra, 2009, The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance, Nat. Immunol., 10, 92, 10.1038/ni.1673 Lombardi, 2011, Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes, Curr. Opin. Struct. Biol., 21, 735, 10.1016/j.sbi.2011.08.004 West, 2014, New and emerging HDAC inhibitors for cancer treatment, J. Clin. Invest., 124, 30, 10.1172/JCI69738 Mariadason, 2000, Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer, Cancer Res., 60, 4561 Glaser, 2003, Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines, Mol. Cancer Ther., 2, 151 Bach Knudsen, 2018, Impact of diet-modulated butyrate production on intestinal barrier function and inflammation, Nutrients, 10, 10.3390/nu10101499 Peng, 2009, Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers, J. Nutr., 139, 1619, 10.3945/jn.109.104638 Rivas-Santiago, 2006, Péptidos antimicrobianos en la inmunidad innata de enfermedades infecciosas, Salud Pública de México, 48, 62, 10.1590/S0036-36342006000100010 Giuliani, 2008, Antimicrobial peptides: natural templates for synthetic membrane-active compounds, Cell. Mol. Life Sci., 65, 2450, 10.1007/s00018-008-8188-x Hans, 2014, Epithelial antimicrobial peptides: guardian of the oral cavity, Int. J. Pept., 2014, 10.1155/2014/370297 Xhindoli, 2016, The human cathelicidin LL-37--A pore-forming antibacterial peptide and host-cell modulator, Biochim. Biophys. Acta, 1858, 546, 10.1016/j.bbamem.2015.11.003 Ganz, 2003, Defensins: antimicrobial peptides of innate immunity, Nat. Rev. Immunol., 3, 710, 10.1038/nri1180 Lee, 2019, A comprehensive review on current advances in peptide drug development and design, Int. J. Mol. Sci., 20, 2383, 10.3390/ijms20102383 Rivas-Santiago, 2011, Induction of β-defensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis, Clin. Exp. Immunol., 164, 80, 10.1111/j.1365-2249.2010.04313.x Chung, 2020, Vitamin D-cathelicidin axis: at the crossroads between protective immunity and pathological inflammation during infection, Immune Netw., 20, 10.4110/in.2020.20.e12 Robinson, 2018, Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics, Anim. Nutr. (Zhongguo xu mu shou yi xue hui), 4, 160 Ottosson, 2016, Potent inducers of endogenous antimicrobial peptides for host directed therapy of infections, Sci. Rep., 6, 36692, 10.1038/srep36692 Chandran, 2015, Mycobacterium tuberculosis infection induces HDAC1-mediated suppression of IL-12B gene expression in macrophages, Front. Cell. Infect. Microbiol., 5, 10.3389/fcimb.2015.00090 Garcia-Garcia, 2009, Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum, PLoS Pathog., 5, 10.1371/journal.ppat.1000488 Bandyopadhaya, 2016, A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming, Nat. Microbiol., 1, 16174, 10.1038/nmicrobiol.2016.174 Wang, 2018, Histone deacetylase 6 inhibitor enhances resistance to Mycobacterium tuberculosis infection through innate and adaptive immunity in mice, Pathog. Dis., 76, 10.1093/femspd/fty064 Yin, 2011, Epigenetic regulation of human beta-defensin 2 and CC chemokine ligand 20 expression in gingival epithelial cells in response to oral bacteria, Mucosal Immunol., 4, 409, 10.1038/mi.2010.83 Kallsen, 2012, Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells, PLoS One, 7, 10.1371/journal.pone.0050000 Liu, 2013, Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells, J. Inflamm. (Lond. Engl.), 10 Schulthess, 2019, The short chain fatty acid butyrate imprints an antimicrobial program in macrophages, Immunity, 50, 432, 10.1016/j.immuni.2018.12.018 Gudmundsson, 2010, Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides, Biochem. Biophys. Res. Commun., 396, 116, 10.1016/j.bbrc.2010.03.081 Mily, 2015, Significant effects of oral phenylbutyrate and vitamin D3 adjunctive therapy in pulmonary tuberculosis: a randomized controlled trial, PLoS One, 10, 10.1371/journal.pone.0138340 Sarker, 2017, Treatment with entinostat heals experimental cholera by affecting physical and chemical barrier functions of intestinal epithelia, Antimicrob. Agents Chemother., 61, 10.1128/AAC.02570-16 Duffy, 2018, Why are RNA virus mutation rates so damn high?, PLoS Biol., 16, 10.1371/journal.pbio.3000003 Vázquez-Calvo, 2011, Inhibition of enveloped virus infection of cultured cells by valproic acid, J. Virol., 85, 1267, 10.1128/JVI.01717-10 Shi, 2019, Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway, Life Sci., 232, 10.1016/j.lfs.2019.116613 Stebe-Frick, 2018, Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue, Sci. Rep., 8, 10.1038/s41598-018-31125-x Kumar, 2015, Epigenetic control of HIV-1 post integration latency: implications for therapy, Clin. Epigenetics, 7, 103, 10.1186/s13148-015-0137-6 Belrose, 2011, Effects of valproate on tax and HBZ expression in HTLV-1 and HAM/TSP t lymphocytes, Blood, 118, 2483, 10.1182/blood-2010-11-321364 Kozlov, 2014, Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes, Biochemistry (Moscow), 79, 637, 10.1134/S0006297914070050 Zhou, 2018, Histone deacetylase 3 inhibitor suppresses hepatitis C virus replication by regulating Apo-A1 and LEAP-1 expression, Virol. Sin., 33, 418, 10.1007/s12250-018-0057-7 Torrent, 2012, Antimicrobial peptide action on parasites, Curr. Drug Targets, 13, 1138, 10.2174/138945012802002393 Hesping, 2020, An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation, Int. J. Parasitol. Drugs Drug Resist., 14, 249, 10.1016/j.ijpddr.2020.10.010 Guidi, 2018, Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production, Parasit Vectors, 11, 668, 10.1186/s13071-018-3268-8 Li, 2009, Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2, Exp. Dermatol., 18, 603, 10.1111/j.1600-0625.2008.00832.x Garnaud, 2016, Histone deacetylases and their inhibition in Candida species, Front. Microbiol., 7, 10.3389/fmicb.2016.01238 Ariffin, 2015, Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages, Antimicrob. Agents Chemother., 60, 1521, 10.1128/AAC.01876-15 Abdossamadi, 2017, Human Neutrophil Peptide 1 as immunotherapeutic agent against Leishmania infected BALB/c mice, PLoS Negl. Trop. Dis., 11, 10.1371/journal.pntd.0006123 Robinson, 2018, Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics, Anim. Nutr., 4, 160, 10.1016/j.aninu.2018.01.003 Fischer, 2016, Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge, Proc. Natl. Acad. Sci. U. S. A., 113, E2993, 10.1073/pnas.1605997113 Miraglia, 2016, Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors, Sci. Rep., 6, 33274, 10.1038/srep33274 Dhawan, 2015, C/EBPα and the vitamin d receptor cooperate in the regulation of Cathelicidin in lung epithelial cells, J. Cell. Physiol., 230, 464, 10.1002/jcp.24729 Dhawan, 2015, C/EBPα and the vitamin D receptor cooperate in the regulation of Cathelicidin in lung epithelial cells, J. Cell. Physiol., 230, 464, 10.1002/jcp.24729 Lagace, 2004, Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis, J. Biol. Chem., 279, 18851, 10.1074/jbc.M312795200 Fang, 2018, Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression, J. Inflamm., 15, 3, 10.1186/s12950-018-0179-6 Stebe-Frick, 2018, Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue, Sci. Rep., 8, 12886, 10.1038/s41598-018-31125-x Sanford, 2016, Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands, Sci. Immunol., 1, 10.1126/sciimmunol.aah4609 Ha, 2014, HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages, J. Immunol. (Baltimore, Md. : 1950), 193, 1333 Yang, 2014, The interaction of the atm genotype with inflammation and oxidative stress, PLoS One, 9 Poralla, 2015, Histone deacetylase 5 regulates the inflammatory response of macrophages, J. Cell. Mol. Med., 19, 2162, 10.1111/jcmm.12595 Shakespear, 2013, Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages, J. Biol. Chem., 288, 25362, 10.1074/jbc.M113.496281 Dahiya, 2020, HDAC10 deletion promotes Foxp3(+) T-regulatory cell function, Sci. Rep., 10, 424, 10.1038/s41598-019-57294-x Miraglia, 2016, Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1alpha transcription factors, Sci. Rep., 6, 33274, 10.1038/srep33274 Steinmann, 2009, Phenylbutyrate induces antimicrobial peptide expression, Antimicrob. Agents Chemother., 53, 5127, 10.1128/AAC.00818-09 Raqib, 2012, Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial, BMC Infect. Dis., 12, 111, 10.1186/1471-2334-12-111 Xiong, 2016, Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition, Sci. Rep., 6, 10.1038/srep27070