Mizoribine: Mode of action and effects in clinical use

Pediatrics International - Tập 44 Số 2 - Trang 196-198 - 2002
Shumpei Yokota1
1Department of Pediatrics, YokohamaCity University School of Medicine

Tóm tắt

AbstractMizoribine is a new immunosuppressive drug and was authorized by the Japanese Government in 1984. The strong immunosuppressive activity of mizoribine was already demonstrated in various animal models, in renal transplantation and in steriod‐resistant nephrotic syndrome. Recently, the remarkable clinical advantages of an imidazole for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases were reported. Mizoribine is an imidazole nucleoside and the metabolites, MZ‐5‐P, exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. Thus, mizoribine is superior to azathioprine, in that it may not cause damages to normal cells and normal nucleic acid.

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Pediatrics International

Tập 44 Số 2

196-198

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