Minireview: Glucocorticoid trong Tự Miễn Dịch: Các Mục Tiêu và Cơ Chế Bất Ngờ

Ward, 1951, Clinical effects of cortisone administered orally to 100 patients with rheumatoid arthritis., Ann Rheum Dis, 10, 477

Hench, 1949, Adrenocortical hormone in arthritis: preliminary report., Ann Rheum Dis, 8, 97, 10.1136/ard.8.2.97

Schappert, 2008, Ambulatory medical care utilization estimates for 2006, Natl Health Stat Report, 1

Tarcic, 1998, Restraint stress-induced thymic involution and cell apoptosis are dependent on endogenous glucocorticoids., J Neuroimmunol, 82, 40, 10.1016/S0165-5728(97)00186-0

Pratt, 2004, Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement., Cell Signal, 16, 857, 10.1016/j.cellsig.2004.02.004

Lefstin, 1998, Allosteric effects of DNA on transcriptional regulators., Nature, 392, 885, 10.1038/31860

Margolis, 2005, The nuclear receptor signaling atlas: development of a functional atlas of nuclear receptors., Mol Endocrinol, 19, 2433, 10.1210/me.2004-0461

Stallcup, 2003, The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators., J Steroid Biochem Mol Biol, 85, 139, 10.1016/S0960-0760(03)00222-X

Xu, 2003, Review of the in vivo functions of the p160 steroid receptor coactivator family., Mol Endocrinol, 17, 1681, 10.1210/me.2003-0116

Rogatsky, 2002, Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts., Proc Natl Acad Sci USA, 99, 16701, 10.1073/pnas.262671599

Rogatsky, 2001, Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones., EMBO J, 20, 6071, 10.1093/emboj/20.21.6071

Tveita, 2010, The danger model in deciphering autoimmunity., Rheumatology, 49, 632, 10.1093/rheumatology/keq004

Sundrud, 2010, Synergistic and combinatorial control of T cell activation and differentiation by transcription factors., Curr Opin Immunol, 22, 286, 10.1016/j.coi.2010.03.006

Hsieh, 1993, Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages., Science, 260, 547, 10.1126/science.8097338

Rogge, 1998, The role of Stat4 in species-specific regulation of Th cell development by type I IFNs., J Immunol, 161, 6567, 10.4049/jimmunol.161.12.6567

Harrington, 2005, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages., Nat Immunol, 6, 1123, 10.1038/ni1254

Manel, 2008, The differentiation of human T(H)-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt., Nat Immunol, 9, 641, 10.1038/ni.1610

Damsker, 2010, Th1 and Th17 cells: adversaries and collaborators., Ann NY Acad Sci, 1183, 211, 10.1111/j.1749-6632.2009.05133.x

Terato, 1992, Induction of arthritis with monoclonal antibodies to collagen., J Immunol, 148, 2103, 10.4049/jimmunol.148.7.2103

Steinman, 2007, A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage., Nat Med, 13, 139, 10.1038/nm1551

Takahashi, 1996, Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice., J Clin Invest, 97, 1597, 10.1172/JCI118584

Wang, 1997, Interferon-γ impacts at multiple points during the progression of autoimmune diabetes., Proc Natl Acad Sci USA, 94, 13844, 10.1073/pnas.94.25.13844

Hölttä, 2008, IL-23/IL-17 immunity as a hallmark of Crohn's disease., Inflamm Bowel Dis, 14, 1175, 10.1002/ibd.20475

Zheng, 2007, Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis., Nature, 445, 648, 10.1038/nature05505

Matusevicius, 1999, Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis., Mult Scler, 5, 101, 10.1177/135245859900500206

Chabaud, 1999, Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium., Arthritis Rheum, 42, 963, 10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E

Tzartos, 2008, Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis., Am J Pathol, 172, 146, 10.2353/ajpath.2008.070690

Kebir, 2007, Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation., Nat Med, 13, 1173, 10.1038/nm1651

Langrish, 2005, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation., J Exp Med, 201, 233, 10.1084/jem.20041257

Chen, 2006, Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis., J Clin Invest, 116, 1317, 10.1172/JCI25308

Park, 2005, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17., Nat Immunol, 6, 1133, 10.1038/ni1261

Edgerton, 2009, IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice., Clin Immunol, 130, 313, 10.1016/j.clim.2008.09.019

Crispín, 2008, Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys., J Immunol, 181, 8761, 10.4049/jimmunol.181.12.8761

Wong, 2008, Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity., Clin Immunol, 127, 385, 10.1016/j.clim.2008.01.019

Luger, 2008, Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category., J Exp Med, 205, 799, 10.1084/jem.20071258

Elenkov, 2004, Glucocorticoids and the Th1/Th2 balance., Ann NY Acad Sci, 1024, 138, 10.1196/annals.1321.010

Ramírez, 1996, Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro., J Immunol, 156, 2406, 10.4049/jimmunol.156.7.2406

DeKruyff, 1998, Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production., J Immunol, 160, 2231, 10.4049/jimmunol.160.5.2231

Blotta, 1997, Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes., J Immunol, 158, 5589, 10.4049/jimmunol.158.12.5589

Wu, 1998, Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness., J Immunol, 161, 2723, 10.4049/jimmunol.161.6.2723

Fahey, 2006, Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent., J Leukoc Biol, 80, 133, 10.1189/jlb.0605296

Luther, 2009, Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients., J Immunol, 183, 841, 10.4049/jimmunol.0802046

Zhou, 2007, IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways., Nat Immunol, 8, 967, 10.1038/ni1488

Waage, 1990, Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts., Eur J Immunol, 20, 2439, 10.1002/eji.1830201112

Flammer, 2010, Type I interferon signaling pathway is a target for glucocorticoid Inhibition., Mol Cell Biol, 30, 4564, 10.1128/MCB.00146-10

Zitnik, 1994, Glucocorticoid inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts: evidence for transcriptional and post-transcriptional regulatory mechanisms., Am J Respir Cell Mol Biol, 10, 643, 10.1165/ajrcmb.10.6.7516173

Vieira, 1998, Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential., J Immunol, 161, 5245, 10.4049/jimmunol.161.10.5245

Monari, 2009, A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production., J Immunol, 183, 191, 10.4049/jimmunol.0804144

Momcilović, 2008, Methylprednisolone inhibits interleukin-17 and interferon-γ expression by both naive and primed T cells., BMC Immunol, 9, 47, 10.1186/1471-2172-9-47

Yang, 2009, Inhibitory effect of rapamycin and dexamethasone on production of IL-17 and IFN-γ in Vogt-Koyanagi-Harada patients., Br J Ophthalmol, 93, 249, 10.1136/bjo.2008.142489

Velten, 2004, A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro., Eur J Immunol, 34, 2800, 10.1002/eji.200324732

Duperrier, 2005, Immunosuppressive agents mediate reduced allostimulatory properties of myeloid-derived dendritic cells despite induction of divergent molecular phenotypes., Mol Immunol, 42, 1531, 10.1016/j.molimm.2005.01.006

Bornstein, 2004, Impaired adrenal stress response in toll-like receptor 2-deficient mice., Proc Natl Acad Sci USA, 101, 16695, 10.1073/pnas.0407550101

Graudal, 2010, Similar effects of disease-modifying antirheumatic drugs, glucocorticoids, and biologic agents on radiographic progression in rheumatoid arthritis: meta-analysis of 70 randomized placebo-controlled or drug-controlled studies, including 112 comparisons., Arthritis Rheum, 62, 2852, 10.1002/art.27592

Gorter, 2010, Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis., Ann Rheum Dis, 69, 1010, 10.1136/ard.2009.127332

De Bosscher, 2009, Minireview: latest perspectives on antiinflammatory actions of glucocorticoids., Mol Endocrinol, 23, 281, 10.1210/me.2008-0283

Jonat, 1990, Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone., Cell, 62, 1189, 10.1016/0092-8674(90)90395-U

Yang-Yen, 1990, Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction., Cell, 62, 1205, 10.1016/0092-8674(90)90396-V

Nissen, 2000, The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain., Genes Dev, 14, 2314, 10.1101/gad.827900

Luecke, 2005, The glucocorticoid receptor blocks P-TEFb recruitment by NFκB to effect promoter-specific transcriptional repression., Genes Dev, 19, 1116, 10.1101/gad.1297105

König, 1992, Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo., EMBO J, 11, 2241, 10.1002/j.1460-2075.1992.tb05283.x

Yamamoto, 1998, Building transcriptional regulatory complexes: signals and surfaces., Cold Spring Harb Symp Quant Biol, 63, 587, 10.1101/sqb.1998.63.587

Ray, 1994, Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor., Proc Natl Acad Sci USA, 91, 752, 10.1073/pnas.91.2.752

Kamei, 1996, A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors., Cell, 85, 403, 10.1016/S0092-8674(00)81118-6

De Bosscher, 2001, Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators., Mol Endocrinol, 15, 219, 10.1210/mend.15.2.0591

De Bosscher, 2000, Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell., Proc Natl Acad Sci USA, 97, 3919, 10.1073/pnas.97.8.3919

Scheinman, 1995, Role of transcriptional activation of I κ B α in mediation of immunosuppression by glucocorticoids., Science, 270, 283, 10.1126/science.270.5234.283

Auphan, 1995, Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of I κB synthesis., Science, 270, 286, 10.1126/science.270.5234.286

Brostjan, 1996, Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis., J Biol Chem, 271, 19612, 10.1074/jbc.271.32.19612

Pérez, 2001, Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor., FASEB J, 15, 2030, 10.1096/fj.00-0772fje

De Bosscher, 1997, Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation., Proc Natl Acad Sci USA, 94, 13504, 10.1073/pnas.94.25.13504

Cato, 2002, Recent advances in glucocorticoid receptor action, 10.1007/978-3-662-04660-9

Kassel, 2001, Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1., EMBO J, 20, 7108, 10.1093/emboj/20.24.7108

Lasa, 2002, Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38., Mol Cell Biol, 22, 7802, 10.1128/MCB.22.22.7802-7811.2002

Abraham, 2006, Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1., J Exp Med, 203, 1883, 10.1084/jem.20060336

Mittelstadt, 2001, Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ., J Biol Chem, 276, 29603, 10.1074/jbc.M101522200

Ayroldi, 2001, Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB., Blood, 98, 743, 10.1182/blood.V98.3.743

Ank, 2006, IFN-λ: novel antiviral cytokines., J Interferon Cytokine Res, 26, 373, 10.1089/jir.2006.26.373

Sheppard, 2003, IL-28, IL-29 and their class II cytokine receptor IL-28R., Nat Immunol, 4, 63, 10.1038/ni873

Kotenko, 2003, IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex., Nat Immunol, 4, 69, 10.1038/ni875

Evans, 1971, Raised antibody titres to E.B. virus in systemic lupus erythematosus., Lancet, 1, 167, 10.1016/S0140-6736(71)91937-4

James, 1997, An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus., J Clin Invest, 100, 3019, 10.1172/JCI119856

Rönnblom, 1990, Possible induction of systemic lupus erythematosus by interferon-α treatment in a patient with a malignant carcinoid tumour., J Intern Med, 227, 207, 10.1111/j.1365-2796.1990.tb00144.x

Wesche, 2001, Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon α therapy for chronic hepatitis C., Gut, 48, 378, 10.1136/gut.48.3.378

Kiehne, 1997, Thyroid autoantibodies and thyroid dysfunction during treatment with interferon-α for chronic hepatitis C., Endocrine, 6, 231, 10.1007/BF02820497

Rosenthal, 1990, Organ-specific hematopoietic changes induced by a recombinant human interferon-α in mice., Fundam Appl Toxicol, 14, 666, 10.1016/0272-0590(90)90292-R

Rahman, 2008, Systemic lupus erythematosus., N Engl J Med, 358, 929, 10.1056/NEJMra071297

Hargraves, 1969, Discovery of the LE cell and its morphology., Mayo Clin Proc, 44, 579

Friou, 1967, Antinuclear antibodies: diagnostic significance and methods., Arthritis Rheum, 10, 151, 10.1002/art.1780100210

Preble, 1982, Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon., Science, 216, 429, 10.1126/science.6176024

Hooks, 1979, Immune interferon in the circulation of patients with autoimmune disease., N Engl J Med, 301, 5, 10.1056/NEJM197907053010102

Bengtsson, 2000, Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies., Lupus, 9, 664, 10.1191/096120300674499064

Ytterberg, 1982, Serum interferon levels in patients with systemic lupus erythematosus., Arthritis Rheum, 25, 401, 10.1002/art.1780250407

von Wussow, 1989, MX homologous protein in mononuclear cells from patients with systemic lupus erythematosus., Arthritis Rheum, 32, 914, 10.1002/j.2326-5205.1989.tb00024.x

Crow, 2003, Microarray analysis of gene expression in lupus., Arthritis Res Ther, 5, 279, 10.1186/ar1015

Bennett, 2003, Interferon and granulopoiesis signatures in systemic lupus erythematosus blood., J Exp Med, 197, 711, 10.1084/jem.20021553

Baechler, 2003, Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus., Proc Natl Acad Sci USA, 100, 2610, 10.1073/pnas.0337679100

Levy, 2003, Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity., Curr Opin Immunol, 15, 52, 10.1016/S0952-7915(02)00011-0

Marié, 1998, Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7., EMBO J, 17, 6660, 10.1093/emboj/17.22.6660

Thanos, 1995, Identification of the rel family members required for virus induction of the human β interferon gene., Mol Cell Biol, 15, 152, 10.1128/MCB.15.1.152

Sharma, 2003, Triggering the interferon antiviral response through an IKK-related pathway., Science, 300, 1148, 10.1126/science.1081315

Geiss, 2001, A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling., J Biol Chem, 276, 30178, 10.1074/jbc.C100137200

Shuai, 2003, Regulation of JAK-STAT signalling in the immune system., Nat Rev Immunol, 3, 900, 10.1038/nri1226

Martinez-Moczygemba, 1997, Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-α-stimulated transcription factor ISGF3., J Biol Chem, 272, 20070, 10.1074/jbc.272.32.20070

McCoy, 2008, Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation., J Biol Chem, 283, 14277, 10.1074/jbc.M709731200

Kishore, 2002, IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2., J Biol Chem, 277, 13840, 10.1074/jbc.M110474200

Hemmi, 2004, The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection., J Exp Med, 199, 1641, 10.1084/jem.20040520

Reily, 2006, The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression., EMBO J, 25, 108, 10.1038/sj.emboj.7600919

Ogawa, 2005, Molecular determinants of crosstalk between nuclear receptors and toll-like receptors., Cell, 122, 707, 10.1016/j.cell.2005.06.029

Guiducci, 2010, TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus., Nature, 465, 937, 10.1038/nature09102

Lepelletier, 2010, Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs)., Blood, 116, 3389, 10.1182/blood-2010-05-282913

Bianchi, 2000, Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids., Proc Natl Acad Sci USA, 97, 9573, 10.1073/pnas.160099797

Stöcklin, 1996, Functional interactions between Stat5 and the glucocorticoid receptor., Nature, 383, 726, 10.1038/383726a0

Lerner, 2003, STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the α 2-macroglobulin gene., Genes Dev, 17, 2564, 10.1101/gad.1135003

Lechner, 1997, Promoter-dependent synergy between glucocorticoid receptor and Stat5 in the activation of β-casein gene transcription., J Biol Chem, 272, 20954, 10.1074/jbc.272.33.20954

Cella, 1998, Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells., Mol Cell Biol, 18, 1783, 10.1128/MCB.18.4.1783

Jeong, 2006, The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism., Mol Endocrinol, 20, 1138, 10.1210/me.2005-0407

Chopra, 2008, Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease., Science, 322, 1395, 10.1126/science.1164847

Bhandare, 2010, Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells., Am J Respir Cell Mol Biol, 42, 9, 10.1165/rcmb.2009-0239RC

Gehin, 2002, The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP., Mol Cell Biol, 22, 5923, 10.1128/MCB.22.16.5923-5937.2002

Picard, 2002, SRC-1 and TIF2 control energy balance between white and brown adipose tissues., Cell, 111, 931, 10.1016/S0092-8674(02)01169-8

Mukherjee, 2006, Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse., Mol Cell Biol, 26, 6571, 10.1128/MCB.00654-06

Patchev, 2007, Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice., FASEB J, 21, 231, 10.1096/fj.06-6952com

Graham, 2006, A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus., Nat Genet, 38, 550, 10.1038/ng1782

Sigurdsson, 2005, Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus., Am J Hum Genet, 76, 528, 10.1086/428480

Fanzo, 2006, Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity., J Clin Invest, 116, 703, 10.1172/JCI24096

Biswas, 2010, IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?, Immunol Rev, 233, 79, 10.1111/j.0105-2896.2009.00864.x

Chen, 2008, IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor., Immunity, 29, 899, 10.1016/j.immuni.2008.10.011

Biswas, 2010, Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice., J Clin Invest, 120, 3280, 10.1172/JCI42856