Metformin-associated lactic acidosis: Current perspectives on causes and risk

Metabolism - Tập 65 Số 2 - Trang 20-29 - 2016
Ralph A. DeFronzo1, G. Alexander Fleming2, Kim Chen3, Thomas A. Bicsak4
1University of Texas Health Science Center at San Antonio, San Antonio, TX USA
2Kinexum LLC, Harpers Ferry, WV, USA.
3Elcelyx Therapeutics, Inc., San Diego, CA, USA.
4Elcelyx Therapeutics, Inc., San Diego, CA, USA. Electronic address: [email protected].

Tóm tắt

Từ khóa


Tài liệu tham khảo

Inzucchi, 2012, Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), Diabetes Care, 35, 1364, 10.2337/dc12-0413

Davidson, 1997, An overview of metformin in the treatment of type 2 diabetes mellitus, Am J Med, 102, 99, 10.1016/S0002-9343(96)00353-1

Bailey, 1996, Metformin, N Engl J Med, 334, 574, 10.1056/NEJM199602293340906

2012, Standards of medical care in diabetes—2012, Diabetes Care, 35, S11

Huang, 2015, Helicobacter pylori infection decreases metformin tolerance in patients with type 2 diabetes mellitus, Diabetes Technol Ther, 17, 128, 10.1089/dia.2014.0203

2009

Bailey, 1992, Biguanides and NIDDM, Diabetes Care, 15, 755, 10.2337/diacare.15.6.755

Peters, 2008, Metformin-associated lactic acidosis in an intensive care unit, Crit Care, 12, R149, 10.1186/cc7137

Misbin, 1998, Lactic acidosis in patients with diabetes treated with metformin, N Engl J Med, 338, 265, 10.1056/NEJM199801223380415

Rocha, 2013, Metformin in patients with chronic kidney disease: strengths and weaknesses, J Nephrol, 26, 55, 10.5301/jn.5000166

Eppenga, 2014, Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study, Diabetes Care, 37, 2218, 10.2337/dc13-3023

Richy, 2014, Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study, Diabetes Care, 37, 2291, 10.2337/dc14-0464

DeFronzo, 1995, Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group, N Engl J Med, 333, 541, 10.1056/NEJM199508313330902

Waters, 1978, Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas, Diabetologia, 14, 95, 10.1007/BF01263446

Fery, 1997, Effects of metformin on the pathways of glucose utilization after oral glucose in non-insulin-dependent diabetes mellitus patients, Metabolism, 46, 227, 10.1016/S0026-0495(97)90307-3

Chan, 1999, Metformin-associated lactic acidosis: a rare or very rare clinical entity?, Diabet Med, 16, 273, 10.1046/j.1464-5491.1999.00006.x

Wang, 2003, Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin, Mol Pharmacol, 63, 844, 10.1124/mol.63.4.844

Bailey, 2008, Metformin and the intestine, Diabetologia, 51, 1552, 10.1007/s00125-008-1053-5

Graham, 2011, Clinical pharmacokinetics of metformin, Clin Pharmacokinet, 50, 81, 10.2165/11534750-000000000-00000

Kajbaf, 2015, Unexpectedly long half-life of metformin elimination in cases of metformin accumulation, Diabet Med

Ncomanzi, 2014, Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report, J Med Case Rep, 8, 159, 10.1186/1752-1947-8-159

Naunton, 2014, Pharmacist review prevents evolving metformin-associated lactic acidosis, J Clin Pharm Ther, 39, 567, 10.1111/jcpt.12187

Hussain, 2014, Acute renal failure and metformin-associated lactic acidosis following colonoscopy, Diabetes Res Clin Pract, 105, e6, 10.1016/j.diabres.2013.12.055

Kim, 2015, Metformin-associated lactic acidosis: predisposing factors and outcome, Endocrinol Metab, 30, 78, 10.3803/EnM.2015.30.1.78

Bridges, 2014, Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria, Biochem J, 462, 475, 10.1042/BJ20140620

Owen, 2000, Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain, Biochem J, 348, 607, 10.1042/bj3480607

Almirall, 2008, Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice, Nephrol Dial Transplant, 23, 2436, 10.1093/ndt/gfn152

Lucis, 1983, The status of metformin in Canada, Can Med Assoc J, 128, 24

Frid, 2010, Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations, Diabetes Care, 33, 1291, 10.2337/dc09-1284

Kalantar-Zadeh, 2013, Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion, N Engl J Med, 369, 374, 10.1056/NEJMcpc1208154

Lalau, 2001, Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis', Diabetes Obes Metab, 3, 195, 10.1046/j.1463-1326.2001.00128.x

Devetzis, 2011, Metformin-related lactic acidosis in patients with acute kidney injury, Int Urol Nephrol, 43, 1243, 10.1007/s11255-010-9845-1

Silvestre, 2007, Metformin-induced lactic acidosis: a case series, J Med Case Rep, 1, 126, 10.1186/1752-1947-1-126

Bruijstens, 2008, Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment, Neth J Med, 66, 185

Keller, 2011, Management of metformin-associated lactic acidosis by continuous renal replacement therapy, PLoS One, 6, e23200, 10.1371/journal.pone.0023200

Brassoe, 2005, Fulminant lactic acidosis in two patients with type 2 diabetes treated with metformin, Diabet Med, 22, 1451, 10.1111/j.1464-5491.2005.01650.x

Laforest, 2013, Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis, Int J Clin Pharmacol Ther, 51, 147, 10.5414/CP201728

Fitzgerald, 2009, Metformin associated lactic acidosis, BMJ, 339, b3660, 10.1136/bmj.b3660

Padwal, 2011, Effect of gastric bypass surgery on the absorption and bioavailability of metformin, Diabetes Care, 34, 1295, 10.2337/dc10-2140

Guelho, 2014, Relation between metformin treatment and the development of hyperlactacidemia at the emergency room, Acta Med Port, 27, 196, 10.20344/amp.4071

Pernicova, 2014, Metformin - mode of action and clinical implications for diabetes and cancer, Nat Rev Endocrinol, 10, 143, 10.1038/nrendo.2013.256

Blough, 2015, Metformin-induced lactic acidosis with emphasis on the anion gap, Proc (Bayl Univ Med Cent), 28, 31, 10.1080/08998280.2015.11929178

Margiani, 2014, Metformin-associated lactic acidosis and temporary ileostomy: a case report, J Med Case Rep, 8, 449, 10.1186/1752-1947-8-449

Stades, 2004, Metformin and lactic acidosis: cause or coincidence? A review of case reports, J Intern Med, 255, 179, 10.1046/j.1365-2796.2003.01271.x

Lalau, 1999, Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations, Drug Saf, 20, 377, 10.2165/00002018-199920040-00006

Kajbaf, 2013, The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis, BMC Pharmacol Toxicol, 14, 22, 10.1186/2050-6511-14-22

Lalau, 2014, Interpreting the consequences of metformin accumulation in an emergency context: impact of the time frame on the blood metformin levels, Int J Endocrinol, 2014, 717198, 10.1155/2014/717198

Vecchio, 2011, Metformin-induced lactic acidosis: no one left behind, Crit Care, 15, 107, 10.1186/cc9404

Arroyo, 2010, The MALAdy of metformin poisoning: is CVVH the cure?, Am J Ther, 17, 96, 10.1097/MJT.0b013e318197eab6

Seidowsky, 2009, Metformin-associated lactic acidosis: a prognostic and therapeutic study, Crit Care Med, 37, 2191, 10.1097/CCM.0b013e3181a02490

Friesecke, 2010, Outcome of severe lactic acidosis associated with metformin accumulation, Crit Care, 14, R226, 10.1186/cc9376

Levey, 2006, Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate, Ann Intern Med, 145, 247, 10.7326/0003-4819-145-4-200608150-00004

Sambol, 1995, Kidney function and age are both predictors of pharmacokinetics of metformin, J Clin Pharmacol, 35, 1094, 10.1002/j.1552-4604.1995.tb04033.x

Misbin, 2004, The phantom of lactic acidosis due to metformin in patients with diabetes, Diabetes Care, 27, 1791, 10.2337/diacare.27.7.1791

Goergen, 2010, Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin, Radiology, 254, 261, 10.1148/radiol.09090690

Calabrese, 2002, Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy, Arch Intern Med, 162, 434, 10.1001/archinte.162.4.434

Horlen, 2002, Frequency of inappropriate metformin prescriptions, JAMA, 287, 2504, 10.1001/jama.287.19.2504-a

Emslie-Smith, 2001, Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines, Diabet Med, 18, 483, 10.1046/j.1464-5491.2001.00509.x

Huang, 2015, Adverse event notifications implicating metformin with lactic acidosis in Australia, J Diabetes Complicat, 10.1016/j.jdiacomp.2015.06.001

Sweileh, 2007, Contraindications to metformin therapy among patients with type 2 diabetes mellitus, Pharm World Sci, 29, 587, 10.1007/s11096-007-9095-1

2009, Type 2 diabetes: the management of type 2 diabetes

Rojas, 2013, Metformin: an old but still the best treatment for type 2 diabetes, Diabetol Metab Syndr, 5, 6, 10.1186/1758-5996-5-6

Ekström, 2012, Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register, BMJ Open, 2, e001076, 10.1136/bmjopen-2012-001076

Lipska, 2011, Use of metformin in the setting of mild-to-moderate renal insufficiency, Diabetes Care, 34, 1431, 10.2337/dc10-2361

2012, Cases of lactic acidosis in patients undergoing treatment with metformin for the treatment of type 2 diabetes

Hanatani, 2015, Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients, Int J Clin Pharm, 37, 537, 10.1007/s11096-015-0097-0

Hung, 2015, Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study, Lancet Diabetes Endocrinol, 3, 605, 10.1016/S2213-8587(15)00123-0

Kalantar-Zadeh, 2015, Metformin in chronic kidney disease: more harm than help?, Lancet Diabetes Endocrinol, 3, 579, 10.1016/S2213-8587(15)00133-3

Edwards, 2015, Chronic kidney disease: metformin increases risk of mortality in patients with advanced chronic kidney disease, Nat Rev Nephrol, 11, 443, 10.1038/nrneph.2015.110

Adam, 2014, A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure, Diabet Med, 31, 1032, 10.1111/dme.12515

Jones, 2015, Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure', Diabet Med, 32, 287, 10.1111/dme.12626

Stang, 1999, Incidence of lactic acidosis in metformin users, Diabetes Care, 22, 925, 10.2337/diacare.22.6.925

Perrone, 2011, Occult metformin toxicity in three patients with profound lactic acidosis, J Emerg Med, 40, 271, 10.1016/j.jemermed.2007.11.055

Guo, 2006, Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin, Semin Dial, 19, 80, 10.1111/j.1525-139X.2006.00123.x

Timbrell, 2012, Lactic acidosis secondary to metformin overdose: a case report, J Med Case Rep, 6, 230, 10.1186/1752-1947-6-230

Dell'Aglio, 2010, Metformin overdose with a resultant serum pH of 6.59: survival without sequalae, J Emerg Med, 39, e77, 10.1016/j.jemermed.2007.09.034

Yang, 2009, Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose, Kaohsiung J Med Sci, 25, 93, 10.1016/S1607-551X(09)70047-6

Galea, 2007, Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose, Br J Anaesth, 98, 213, 10.1093/bja/ael347

Panzer, 2004, Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis, Nephrol Dial Transplant, 19, 2157, 10.1093/ndt/gfh337

Chang, 2002, High anion gap metabolic acidosis in suicide: don't forget metformin intoxication—two patients' experiences, Ren Fail, 24, 671, 10.1081/JDI-120013973

Suchard, 2008, Fatal metformin overdose presenting with progressive hyperglycemia, West J Emerg Med, 9, 160

von Mach, 2004, Experiences of a poison center with metformin-associated lactic acidosis, Exp Clin Endocrinol Diabetes, 112, 187, 10.1055/s-2004-819164

Baro-Serra, 2012, The importance of early haemodiafiltration in the treatment of lactic acidosis associated with the administration of metformin, Nefrologia, 32, 664

Heaney, 1997, Bicarbonate haemodialysis as a treatment of metformin overdose, Nephrol Dial Transplant, 12, 1046, 10.1093/ndt/12.5.1046

Lam, 2012, Metformin-associated lactic acidosis following intentional overdose successfully treated with tris-hydroxymethyl aminomethand and renal replacement therapy. Case Reports in, Nephrology, 2012

Harvey, 2005, Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization, Pediatr Crit Care Med, 6, 598, 10.1097/01.PCC.0000162451.47034.4F

Cryer, 2005, Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study, Diabetes Care, 28, 539, 10.2337/diacare.28.3.539

Salpeter, 2010, Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus, Cochrane Database Syst Rev, CD002967

Bodmer, 2008, Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case–control analysis, Diabetes Care, 31, 2086, 10.2337/dc08-1171

Kruse, 2004, Review: metformin does not increase risk for lactic acidosis or increase lactate levels in type 2 diabetes, ACP J Club, 141, 7, 10.7326/ACPJC-2004-141-1-007

Fall, 2005, Lactic acidosis: from sour milk to septic shock, J Intensive Care Med, 20, 255, 10.1177/0885066605278644

Stacpoole, 1993, Lactic acidosis, Endocrinol Metab Clin North Am, 22, 221, 10.1016/S0889-8529(18)30163-4

Bellomo, 2002, Bench-to-bedside review: lactate and the kidney, Crit Care, 6, 322, 10.1186/cc1518

Bartlett, 1984, The influence of renal function on lactate and glucose metabolism, Biochem J, 219, 73, 10.1042/bj2190073

Madiraju, 2014, Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase, Nature, 510, 542, 10.1038/nature13270

Hong, 2008, Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus, J Clin Pharmacol, 48, 696, 10.1177/0091270008316884

Lalau, 1995, Role of metformin accumulation in metformin-associated lactic acidosis, Diabetes Care, 18, 779, 10.2337/diacare.18.6.779

Marchetti, 1987, Plasma biguanide levels are correlated with metabolic effects in diabetic patients, Clin Pharmacol Ther, 41, 450, 10.1038/clpt.1987.55

Scarpello, 2001, Review: optimal dosing strategies for maximising the clinical response to metformin in type 2 diabetes, Br J Diabetes Vasc Dis, 1, 28, 10.1177/14746514010010010501

Davis, 2001, The relationship between metformin therapy and the fasting plasma lactate in type 2 diabetes: the Fremantle Diabetes Study, Br J Clin Pharmacol, 52, 137, 10.1046/j.0306-5251.2001.01423.x

Boulé, 2011, Metformin and exercise in type 2 diabetes: examining treatment modality interactions, Diabetes Care, 34, 1469, 10.2337/dc10-2207

Cunha, 2008, Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide, Diabetes Obes Metab, 10, 238, 10.1111/j.1463-1326.2006.00690.x

Stumvoll, 1995, Metabolic effects of metformin in non-insulin-dependent diabetes mellitus, N Engl J Med, 333, 550, 10.1056/NEJM199508313330903

Protti, 2010, Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication, Crit Care, 14, R22, 10.1186/cc8885

Brunmair, 2004, Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?, Diabetes, 53, 1052, 10.2337/diabetes.53.4.1052

Zmijewski, 2008, Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury, Am J Respir Crit Care Med, 178, 168, 10.1164/rccm.200710-1602OC

El-Mir, 2000, Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I, J Biol Chem, 275, 223, 10.1074/jbc.275.1.223

Al-Abri, 2013, Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs, Clin Toxicol (Phila), 51, 444, 10.3109/15563650.2013.784774

Chen, 2015, metformin administration into the ileum is not associated with increased systemic lactate

Bakris, 2014, Effects of new metformin formulation in stage 3 and 4 CKD: a pilot study, J Am Soc Nephrol, 25, 549A

DeFronzo, 2013, Dissociation between metformin plasma exposure and its glucose-lowering effect: a novel gut-mediated mechanism of action, 1087-P

Buse, 2015, The primary glucose-lowering effect of metformin resides in the gut not the circulation. results from short-term pharmacokinetic and 12-week dose ranging studies, Diabetes Care, 10.2337/dc15-0488