Metastatic pattern of infiltrating lobular carcinoma of the breast: An autopsy study

Journal of Surgical Oncology - Tập 48 Số 1 - Trang 28-33 - 1991
Janez Lamovec1, Matej Bračkko2
1Department of Pathology, Institute of Oncology, Ljubljana, Slovena, Yugoslavia.
2Department of Pathology, the Institute of Oncology, Ljubljana, Slovenia, Yugoslavia

Tóm tắt

AbstractWe analyzed the autopsy records and autopsy histological slides of 261 patients with breast carcinoma who died at the Institute of Oncology, Ljubljana, from January 1972 to October 1989, with particular attention to the metastatic pattern of infiltrating lobular carcinoma (ILC) which we compared with infiltrating ductal carcinoma (IDC). In 226 of 261 patients who died with metastatic disease there were 25 cases of ILC, 195 cases of IDC, 4 cases of mixed IDC–ILC, and 2 cases of mucinous carcinoma. There was no statistically significant difference in frequency of metastases to common metastatic sites, such as the liver, bone, and pleura, with the exception of the lungs, in which IDC metastases prevailed (P <0.006). By contrast, a statistically highly significant prevalence of ILC metastases to the peritoneum/retroperitoneum, hollow viscera, internal genital organs, leptomeninges, and myocardium was found (P values of <0.006‐<10‐6). The metastases to these sites were characterized by diffuse growth of neoplastic cells that infiltrated in a lymphoma or leukemia‐like fashion. Such metastases may remain clinically silent for a long time, in spite of their extensiveness. The difference of metastatic pattern between ILC and IDC is insufficiently appreciated in most of the published studies on ILC.

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Tài liệu tham khảo

10.1097/00000478-199001000-00002

10.1002/1097-0142(197301)31:1<110::AID-CNCR2820310115>3.0.CO;2-V

Wheeler JE, 1976, Lobular carcinoma of the breast—in situ and infiltrating, Pathol Annu, 11, 161

10.1001/archsurg.1979.01370280139021

10.1016/0277-5379(87)90344-0

10.1200/JCO.1989.7.3.355

10.1136/bmj.291.6506.1371

Viadana E, 1973, An autopsy study of metastatic sites of breast cancer, Cancer Res, 33, 179

10.1038/bjc.1973.40

10.1002/jso.2930110303

10.1093/ajcp/73.2.232

10.1002/1097-0142(19800701)46:1<162::AID-CNCR2820460127>3.0.CO;2-B

10.1002/jso.2930190212

10.1002/1097-0142(19831215)52:12<2349::AID-CNCR2820521231>3.0.CO;2-B

10.1002/jso.2930230311

10.1007/BF00050693

Bussani R, 1989, Il carcinoma della mammella all autopsia: può il fattore età agire come variabile determinante nel proceso di metastatizzazione?, Pathologica, 81, 411

Kamby C, 1986, Pattern of human breast carcinoma in relation to estrogen receptor status, Anticancer Res, 6, 107

10.1016/0277-5379(87)90061-7

10.3109/02841868809091774

10.1002/1097-0142(19881115)62:10<2226::AID-CNCR2820621026>3.0.CO;2-D

10.1097/00007611-198809000-00011

10.1038/bjc.1984.135

Foote FW, 1946, A histologic classification of carcinoma of the breast, Surgery, 19, 74

Miller HW, 1956, Infiltrating lobular carcinoma of the female mammary gland, Gynecol Obstet, 102, 661

10.1097/00000658-196608000-00018

10.1016/S0046-8177(75)80099-2

10.1111/j.1365-2559.1979.tb03029.x

10.1111/j.1365-2559.1982.tb02712.x

10.1002/1097-0142(197501)35:1<247::AID-CNCR2820350130>3.0.CO;2-S

Lesser ML, 1982, Multicentricity and bilaterality in invasive breast carcinoma, Surgery, 91, 234

10.1002/bjs.1800700902

10.1002/1097-0142(19841215)54:12<3002::AID-CNCR2820541231>3.0.CO;2-V

10.1002/1097-0142(19860301)57:5<897::AID-CNCR2820570502>3.0.CO;2-T

Rosen PP, 1975, Pathological review of breast lesions analysed for estrogen receptor protein, Cancer Res, 35, 3187

10.1002/1097-0142(19810715)48:2<299::AID-CNCR2820480215>3.0.CO;2-2

Cormier WJ, 1980, Linitis plastica caused by metastatic lobular carcinoma of the breast, Mayo Clin Proc, 55, 747

10.1055/s-2008-1049028

Nyberg B, 1986, Metastatic breast carcinoma causing intestinal obstruction, Acta Chir Scand, 530, 95

Navarette E, 1986, Les métastases gastriques des cancers du sein, J Chir, 126, 294

DiBonito L, 1985, Breast carcinoma metastasizing to the uterus, Eur J Gynaecol Oncol, 6, 211

10.1111/j.1471-0528.1986.tb08665.x

Geller SA, 1975, Ureteral obstruction from metastatic breast carcinoma, Arch Pathol, 99, 476

10.1002/1097-0142(19880501)61:9<1904::AID-CNCR2820610930>3.0.CO;2-1

10.1002/bjs.1800720814

Smith DB, 1985, Carcinomatous meningitis associated with infiltrating lobular carcinoma of the breast, Eur J Surg Oncol, 11, 33

Lamovec J, 1991, Association of leptomeningeal carcinomatosis in carcinoma of the breast with infiltrating lobular carcinoma. An autopsy study, Arch Pathol Lab Med, 115, 507

10.1002/path.1711570308

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Journal of Surgical Oncology

Tập 48 Số 1

28-33

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