Metalloproteinases in chronic and acute wounds: A systematic review and meta‐analysis

Wound Repair and Regeneration - Tập 27 Số 4 - Trang 415-420 - 2019
Aroa Tardáguila‐García1, Esther García‐Morales1,2,3, Josep M García-Alamino4, Francisco Javier Álvaro‐Afonso1, Raúl J. Molines‐Barroso1, José Luís Lázaro‐Martínez1
1Diabetic Foot Unit, Universidad Complutense de Madrid, Madrid, Spain
2Reprint requests:
3Tel: +34 913941609
4DPhil Programme in Evidence-Based Healthcare, University of Oxford, Oxford, United Kingdom.

Tóm tắt

AbstractA systematic review and meta‐analysis were undertaken in order to explore the influence of matrix metalloproteinases and their diagnostic methods in chronic and acute wounds. Searches were conducted in the PubMed (Medline) and Embase (Elsevier) databases from inception to late November 2017. We included clinical trials enrolling patients with cutaneous chronic and acute wounds where a validated diagnostic method was employed for metalloproteinases. We excluded in vitro, animal or preclinical studies, nonoriginal articles, and studies without available data for analysis. In addition, references of narrative and systematic reviews were scrutinized for additional articles. Eight studies met the inclusion criteria. Results revealed that the most frequently determined matrix metalloproteinases were MMP‐2 and MMP‐9, and were found in 54.5% of wounds. MMP‐9 was present in more than 50% of the chronic wounds with a range from 37 to 78%. However, metalloproteinases were found in only 20% of acute wounds, and other types of metalloproteinases were also observed (MMP‐2 and MMP‐3). On the basis of the available evidence, high levels of metalloproteinases have been correlated with significantly delayed wound healing in wounds of a variety of etiologies.

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Thông tin xuất bản

Wound Repair and Regeneration

Tập 27 Số 4

415-420

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