Metabolic profiling of icaritin in rats using UHPLC-Q/TOF-MS

Du, 2015, UPLC-Q-TOF/MS-based screening and identification of the main flavonoids and their metabolites in rat bile, urine and feces after oral administration of Scutellaria baicalensis extract, Journal of Ethnopharmacology, 169, 156, 10.1016/j.jep.2015.04.039

Jiang, 2014, Metabolic profiling of isomeric aglycones central-icaritin (c-IT) and icaritin (IT) in osteoporotic rats by UPLC-QTOF-MS, Drug Testing and Analysis, 7, 309, 10.1002/dta.1672

Jiang, 2016, Pharmacology and clinical application of plants in Epimedium L, Chinese Herbal Medicines, 8, 12, 10.1016/S1674-6384(16)60003-5

Kim, 2017, Potential of icariin metabolites from Epimedium koreanum Nakai as antidiabetic therapeutic agents, Molecules, 22, 986, 10.3390/molecules22060986

Sun, 2018, Protective effect of icaritin on focal cerebral ischemic-reperfusion mice, Chinese Herbal Medicine, 10, 40, 10.1016/j.chmed.2017.12.005

Sun, 2016, Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMPmice, Carcinogenesis, 37, 701, 10.1093/carcin/bgw044

Tan, 2017, TRAF6 Mediates suppression of osteoclastogenesis and prevention of ovariectomy-induced bone loss by a novel prenylflavonoid, Journal of Bone and Mineral Research, 32, 846, 10.1002/jbmr.3031

Tao, 2016, Biotransformation and metabolic profile of buddleoside with human intestinal microflora by ultrahigh-performance liquid chromatography coupled to hybrid linear ion trap/orbitrap mass spectrometer, Journal of Chromatography B, 1025, 7, 10.1016/j.jchromb.2016.04.055

Tao, 2016, Investigation of the interactions between Chrysanthemum morifolium flowers extract and intestinal bacteria from human and rat, Biomedical Chromatography, 30, 1807, 10.1002/bmc.3756

Wang, 2017, Analysis on chemical constituents of Epimedii Folium by UPLC-Q-TOF-MS, Chinese Traditional and Herbal Drugs, 48, 2625

Wu, 2017, Icaritin, a novel plant-derived osteoinductive agent, enhances the osteogenic differentiation of human bone marrow- and human adipose tissue-derived mesenchymal stem cells, International Journal of Molecular Medicine, 39, 984, 10.3892/ijmm.2017.2906

Xu, 2015, Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1a signaling, Clinical and Experimental Pharmacology & Physiology, 42, 1296, 10.1111/1440-1681.12488

Xue, 2011, Screening for in vitro metabolites of Abelmoschus manihot extract in intestinal bacteria by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, Journal of Chromatography B, 879, 3901, 10.1016/j.jchromb.2011.10.043

Yao, 2012, Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis—an in vitro efficacy study, PLoS One, 7, E41264, 10.1371/journal.pone.0041264

Ye, 2015, Identification of icaritin metabolites in rats by LC-MS/MS, Chinese Herbal Medicines, 7, 296, 10.1016/S1674-6384(15)60055-7

Zhang, 2017, Metabolite profiling, pharmacokinetics, and in vitro glucuronidation of icaritin in rats by ultra-performance liquid chromatography coupled with mass spectrometry, Journal of Analytical Methods in Chemistry, 2017, 1, 10.1155/2017/6153802

Zhang, 2017, Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q-TOF and UHPLC-MS/MS, Drug Testing and Analysis, 9, 1604, 10.1002/dta.2188