Metabolic Fate of Sipoglitazar a Novel Oral PPAR Agonist with Activities for PPAR-γ, -α and -δ, in Rats and Monkeys and Comparison with Humans In Vitro

Drug Metabolism and Pharmacokinetics - Tập 27 - Trang 223-231 - 2012
Mitsuhiro Nishihara1, Miyako Sudo1, Hidenori Kamiguchi1, Naohiro Kawaguchi1, Yoshihiro Maeshiba1, Yutaka Kiyota1, Junzo Takahashi1, Yoshihiko Tagawa1, Takahiro Kondo1, Satoru Asahi1
1Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Tài liệu tham khảo

Desvergne, 1999, Peroxisome proliferator-activated receptors: nuclear control of metabolism, Endocr. Rev., 20, 649 Balfour, 1990, Fenofibrate.: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia, Drugs, 40, 260, 10.2165/00003495-199040020-00007 Despres, 2001, Increasing high-density lipoprotein cholesterol: an update on fenofibrate, Am. J. Cardiol., 88, 30N, 10.1016/S0002-9149(01)02150-6 Packard, 2002, Comparison of gemfibrozil and fenofibrate in patients with dyslipidemic coronary heart disease, Pharmacotherapy, 22, 1527, 10.1592/phco.22.17.1527.34128 Haffner, 1999, Insulin sensitivity in subjects with T2DM. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study, Diabetes Care, 22, 562, 10.2337/diacare.22.4.562 Balfour, 1999, Rosiglitazone. Drugs, 57, 921, 10.2165/00003495-199957060-00007 Gillies, 2000, Pioglitazone. Drugs, 60, 333, 10.2165/00003495-200060020-00009 Sprecher, 2007, Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta, Am. J. Cardiol., 100, 20N, 10.1016/j.amjcard.2007.08.009 Kim, 1988, Preclinical toxicology and pharmacology of dimethyl- cetamide with clinical notes, Drug Metab. Rev., 19, 345, 10.3109/03602538808994140 Li, 1999, Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential, Chem. Biol. Interact., 121, 17, 10.1016/S0009-2797(99)00088-5 Loretz, 1989, Optimization of cryopreservation procedures for rat and human hepatocytes, Xenobiotica, 19, 489, 10.3109/00498258909042288 Kintscher, 2005, PPARγ-mediated insulin sensitization: the importance of fat versus muscle, Am. J. Physiol. Endocrinol. Metab., 288, E287, 10.1152/ajpendo.00440.2004 Hyneck, 1988, Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide, Drug Metab. Dispos., 16, 322 Smith, 1985, Stability of acyl glucuronides in blood, plasma, and urine: Studies with zomepirac, Drug Metab. Dispos., 13, 110