Mechanisms of glucocorticoid action in bone

Saag K: Glucocorticoid-induced osteoporosis. Endocrinol Metab Clin North Am 2003, 32:135157. An excellent clinical review on the subject of GIO.

Canalis E, Bilezikian JP, Angeli A, et al.: Perspectives on glucocorticoid induced osteoporosis. Bone 2004, 34:593598. An excellent review on the subject of GIO.

Hattersley AT, Meeran K, Burrin J, et al.: The effect of long- and short-term corticosteroids on plasma calcitonin and parathyroid hormone levels. Calcif Tissue Int 1994, 54:198202.

Rubin MR, Bilezikian JP: The role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: a re-examination of the evidence. J Clin Endocrinol Metab 2002, 87:40334041.

Paz-Pacheco E, Fuleihan GE, Leboff MS: Intact parathyroid hormone levels are not elevated in glucocorticoid-treated subjects. J Bone Miner Res 1995, 10:17131718.

Reid IR, Evans MC, Stapleton J: Lateral spine densitometry is a more sensitive indicator of glucocorticoid-induced bone loss. J Bone Miner Res 1992, 7:12211225.

Suda T, Takahashi N, Udagawa N, et al.: Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999, 20:345357.

Hofbauer LC, Gori F, Riggs BL, et al.: Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 1999, 140:43824389.

Rubin J, Biksobing DM, Jadhav L, et al.: Dexamethasone promotes expression of membrane-bound macrophage colonystimulating factor in murine osteoblast-like cells. Endocrinology 1998, 139:10061012.

Weinstein RS, Chen JR, Powers CC, et al.: Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest 2002, 109:10411048.

Dempster DW, Moonga BS, Stein LS, et al.: Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis. J Endocrinol 1997, 154:397406.

Carbonare LD, Arlot ME, Chavassieux PM, et al.: Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid- induced and postmenopausal osteoporosis. J Bone Miner Res 2001, 16:97103.

Pereira RMR, Delany AM, Canalis E: Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Bone 2001, 28:484490.

Weinstein RS, Jilka RL, Parfitt AM, et al.: Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. J Clin Invest 1998, 102:274282.

Bellows CG, Aubin JE, Heersche JNM: Physiological concentrations of glucocorticoids stimulate formation of bone nodules from isolated rat calvaria cells in vitro. Endocrinology 1987, 212:19851992.

Pereira RC, Delany AM, Canalis E: Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone 2002, 30:685691.

Wu Z, Bucher NLR, Farmer SR: Induction of peroxisome proliferator- activated receptor g during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPb, and glucocorticoids. Mol Cell Biol 1996, 16:41284136.

Pereira RC, Delany AM, Canalis E: CCAAT/Enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. Endocrinology 2004, 145:19521960.

Smas CM, Chen L, Zhao L, et al.: Transcriptional repression of pref-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation. J Biol Chem 1999, 274:1263212641.

Moon YS, Smas CM, Lee K, et al.: Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol 2002, 22:55855592.

Canalis E, Economides AE, Gazzerro E: Bone morphogenetic proteins, their antagonists and the skeleton. Endocr Rev 2003, 24:218235. An excellent review on bone cell biology.

Westendorf JJ, Kahler RA, Schroeder TM: Wnt signaling in osteoblasts and bone diseases. Gene 2004, 341:1939. An excellent clinical review on bone cell biology.

Ohnaka K, Taniguchi H, Kawate H, et al.: Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis. Biochem Biophys Res Comm 2004, 318:259264.

Weinmaster G: Review: the ins and outs of notch signaling. Mol Cell Neurosci 1997, 9:91102.

Sciaudone M, Gazzerro E, Priest L, et al.: Notch 1 impairs osteoblastic cell differentiation. Endocrinology 2003, 144:56315639. New signals involving mechanisms of glucocorticoid action in bone.

Crowe R, Zikherman J, Niswander L: Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation. Development 1999, 126:987998.

DeStrooper B, Annaert W: Where Notch and Wnt signaling meet: the presenilin hub. J Cell Biol 2001, 152:F17F20.

Axelrod JD, Matsuno K, Artavanis-Tsakonas S, et al.: Interaction between Wingless and Notch signaling pathways mediated by Disheveled. Science 1996, 271:18261832.

Foltz DR, Santiago MC, Berechid BE, et al.: Glycogen synthase kinase-3b modulates Notch signaling and stability. Curr Biol 2002, 12:10061011.

Pereira RMR, Delany AM, Durant D, et al.: Cortisol regulates the expression of Notch in osteoblasts. J Cell Biochem 2002, 85:252258.

Delany AM, Durant D, Canalis E: Glucocorticoid suppression of IGF I transcription in osteoblasts. Mol Endocrinol 2001, 15:17811789.

Okazaki R, Briggs BL, Conover CA: Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells. Endocrinology 1994, 134:126132.

Devlin RD, Du Z, Buccilli V, et al.: Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia. Endocrinology 2002, 143:39553962.

Delany A, Gabbitas B, Canalis E: Cortisol down-regulates osteoblast a1 (I) procollagen mRNA by transcriptional and post-transcriptional mechanisms. J Cell Biochem 1995, 57:488494.

Rydziel S, Delany AM, Canalis E: AU-Rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts. J Biol Chem 2004, 279:53975404.

Hock JM, Centrella M, Canalis E: Insulin-like growth factor I (IGF-I) has independent effects on bone matrix formation and cell replication. Endocrinology 1988, 122:2227.

Canalis E: Inhibitory actions of glucocorticoids on skeletal growth. Is local insulin-like growth factor I to blame? Endocrinology 1998, 139:30413042.

Reid IR, Gluckman PD, Ibbertson HK: Insulin-like growth factor I and bone turnover in glucocorticoid-treated and control subjects. Clin Endocrinol (Oxf) 1989, 30:347353.

Bachrach LK: Bare-bones fact children are not small adults. N Engl J Med 2004, 351:924926.

Singleton JR, Baker BL, Thorburn A: Dexamethasone inhibits insulin-like growth factor signaling and potentiates myoblast apoptosis. Endocrinology 2000, 141:29452950.

Dehoux M, Van Beneden R, Pasko N, et al.: Role of the insulinlike growth factor I decline in the induction of atrogin-1/ MAFbx during fasting and diabetes. Endocrinology 2004, 145:48064812.

Tomlinson JW, Walker EA, Bujalski IJ, et al.: 11b-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 2004, 25:831866.