Mechanisms of Opioid-Induced Tolerance and Hyperalgesia

Pain Management Nursing - Tập 8 Số 3 - Trang 113-121 - 2007
Anna DuPen1, Danny D. Shen2, Mary Ersek3
1Pain and Palliative Care Research Department, Swedish Medical Center, Seattle, Washington
2Departments of Pharmacy and Pharmaceutics, University of Washington School of Pharmacy, Seattle, Washington.
3Center for Nursing Excellence, Swedish Medical Center, Seattle, Washington

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Angst, 2006, Opioid-induced hyperalgesia: a qualitative systematic review, Anesthesiology, 104, 570, 10.1097/00000542-200603000-00025

Arden, 1995, Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells, Journal of Neurochemistry, 65, 1636, 10.1046/j.1471-4159.1995.65041636.x

Benitez del Rosario, 2004, Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain, Cancer, 101, 2866, 10.1002/cncr.20712

Bergen, 1997, Mu opioid receptor gene variants: lack of association with alcohol dependence, Molecular Psychiatry, 2, 490, 10.1038/sj.mp.4000331

Bernstein, 1998, Proglumide as a morphine adjunct in cancer pain management, Journal of Pain & Symptom Management, 15, 314, 10.1016/S0885-3924(98)00003-7

Bohn, 2002, Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice, Journal of Neuroscience, 22, 10494, 10.1523/JNEUROSCI.22-23-10494.2002

Bohn, 1999, Enhanced morphine analgesia in mice lacking beta-arrestin 2, Science, 286, 2495, 10.1126/science.286.5449.2495

Bond, 1998, Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction, Proceeding of the National Academies of Science of the United States of America, 95, 9608, 10.1073/pnas.95.16.9608

Celerier, 2000, Long-lasting hyperalgesia induced by fentanyl in rats: Preventive effect of ketamine, Anesthesiology, 92, 465, 10.1097/00000542-200002000-00029

Chavkin, 1982, Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea, Life Sciences, 31, 1687, 10.1016/0024-3205(82)90186-2

Chavkin, 1984, Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus, Proceeding of the National Academies of Science of the United States of America, 81, 7253, 10.1073/pnas.81.22.7253

Chindalore, 2005, Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex, Journal of Pain, 6, 392, 10.1016/j.jpain.2005.01.356

Clark, 1995, Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient, Journal of Pain & Symptom Management, 10, 310, 10.1016/0885-3924(95)00010-V

Collin, 1993, Is disease progression the major factor in morphine “tolerance” in cancer pain treatment?, Pain, 55, 319, 10.1016/0304-3959(93)90007-C

Compton, 1994, Cold-pressor pain tolerance in opiate and cocaine abusers: correlates of drug type and use status, Journal of Pain & Symptom Management, 9, 462, 10.1016/0885-3924(94)90203-8

Compton, 2001, Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent, Drug & Alcohol Dependence, 63, 139, 10.1016/S0376-8716(00)00200-3

Crain, 2000, Antagonists of excitatory opioid receptor functions enhance morphine’s analgesic potency and attenuate opioid tolerance/dependence liability, Pain, 84, 121, 10.1016/S0304-3959(99)00223-7

Davis, 1999, d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia, Journal of Pharmacol Exp Ther, 289, 1048

De Stoutz, 1995, Opioid rotation for toxicity reduction in terminal cancer patients, Journal of Pain Symptom & Management, 10, 378, 10.1016/0885-3924(95)90924-C

Dourish, 1988, Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718, European Journal of Pharmacology, 147, 469, 10.1016/0014-2999(88)90183-5

Doverty, 2001, Hyperalgesic responses in methadone maintenance patients, Pain, 90, 91, 10.1016/S0304-3959(00)00391-2

Drake, 2004, Opioid rotation in children with cancer, Journal of Palliative Medicine, 7, 419, 10.1089/1096621041349590

Duttaroy, 1995, The effect of intrinsic efficacy on opioid tolerance, Anesthesiology, 82, 1226, 10.1097/00000542-199505000-00018

Eilers, 2001, The reversal of fentanyl-induced tolerance by administration of “small-dose” ketamine, Anesthesia & Analgesia, 93, 213, 10.1097/00000539-200107000-00042

Elliott, 1994, Dextromethorphan attenuates and reverses analgesic tolerance to morphine, Pain, 59, 361, 10.1016/0304-3959(94)90022-1

Estfan, 2005, Opioid rotation in cancer patients: pros and cons, Oncology (Williston Park), 19, 511

Ferguson, 1998, Role of beta-arrestins in the intracellular trafficking of G-protein–coupled receptors, Advances in Pharmacology, 42, 420, 10.1016/S1054-3589(08)60778-4

Finn, 2001, Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal, Neuron, 32, 829, 10.1016/S0896-6273(01)00517-7

Foley, 1993, Changing concepts of tolerance to opioids: what the cancer patient has taught us, 331

Galer, 2005, MorphiDex (morphine sulfate/dextromethorphan hydrobromide combination) in the treatment of chronic pain: three multicenter randomized, double-blind, controlled clinical trials fail to demonstrate enhanced opioid analgesia or reduction in tolerance, Pain, 115, 284, 10.1016/j.pain.2005.03.004

Gardell, 2006, Opioid receptor–mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery, Neuroscience Letters, 396, 44, 10.1016/j.neulet.2005.11.009

Gardell, 2002, Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers, Journal of Neuroscience, 22, 6747, 10.1523/JNEUROSCI.22-15-06747.2002

Gorman, 1997, The d- and l-isomers of methadone bind to the noncompetitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord, Neuroscience Letters, 223, 5, 10.1016/S0304-3940(97)13391-2

Haley, 1990, Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat, Brain Research, 518, 218, 10.1016/0006-8993(90)90975-H

Hirota, 2003, Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy, Drug Metabolism & Disposition, 31, 677, 10.1124/dmd.31.5.677

Ho, 2006, Gabapentin and postoperative pain—a systematic review of randomized controlled trials, Pain, 126, 91, 10.1016/j.pain.2006.06.018

Indelicato, 2002, Opioid rotation in the management of refractory cancer pain, Journal of Clinical Oncology, 20, 348, 10.1200/JCO.2002.20.1.348

Ivarsson, 1989, Differences in efficacies between morphine and methadone demonstrated in the guinea pig ileum: a possible explanation for previous observations on incomplete opioid cross-tolerance, Pharmacology & Toxicology, 65, 368, 10.1111/j.1600-0773.1989.tb01190.x

King, 2005, Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?, Neurosignals, 14, 194, 10.1159/000087658

Kloke, 2000, Toxicity and/or insufficient analgesia by opioid therapy: risk factors and the impact of changing the opioid, Support Care in Cancer, 8, 479, 10.1007/s005200000153

Lauretti, 1999, Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management, Anesthesiology, 90, 1528, 10.1097/00000542-199906000-00005

Li, 2000, Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects, American Journal of Medical Genetics, 96, 616, 10.1002/1096-8628(20001009)96:5<616::AID-AJMG6>3.0.CO;2-7

Lotsch, 2002, The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine, Pharmacogenetics, 12, 3, 10.1097/00008571-200201000-00002

Lotsch, 2002, Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?, Anesthesiology, 97, 814, 10.1097/00000542-200210000-00011

Luttrell, 2002, The role of beta-arrestins in the termination and transduction of G-protein–coupled receptor signals, Journal of Cell Science, 115, 455, 10.1242/jcs.115.3.455

Lynch, 2005, A review of the use of methadone for the treatment of chronic noncancer pain, Pain Research & Management, 10, 133, 10.1155/2005/286713

Mansour, 1995, Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications, Trends in Neuroscience, 18, 22, 10.1016/0166-2236(95)93946-U

Mansour, 1987, Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain, Journal of Neuroscience, 7, 2445

Mao, 2002, Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy, Pain, 100, 213, 10.1016/S0304-3959(02)00422-0

Mao, 2006, Opioid-induced abnormal pain sensitivity, Current Pain & Headache Reports, 10, 67, 10.1007/s11916-006-0011-5

Mao, 1994, Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C, Journal of Neuroscience, 14, 2301, 10.1523/JNEUROSCI.14-04-02301.1994

Mao, 1995, Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain, Pain, 61, 353, 10.1016/0304-3959(95)00022-K

Mao, 2002, Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity, Journal of Neuroscience, 22, 8312, 10.1523/JNEUROSCI.22-18-08312.2002

McCleane, 2004, Cholecystokinin antagonists a new way to improve the analgesia from old analgesics?, Current Pharmaceutical Design, 10, 303, 10.2174/1381612043386419

McCleane, 1998, The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain, Anesthesia & Analgesia, 87, 1117, 10.1213/00000539-199811000-00025

McCleane, 2003, The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine, Clinical Journal of Pain, 19, 200, 10.1097/00002508-200305000-00008

McNicol, 2003, Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review, Journal of Pain, 4, 231, 10.1016/S1526-5900(03)00556-X

Mercadante, 1996, Ketamine in cancer pain: an update, Palliative Medicine, 10, 225, 10.1177/026921639601000301

Mercadante, 1999, Opioid rotation for cancer pain: rationale and clinical aspects, Cancer, 86, 1856, 10.1002/(SICI)1097-0142(19991101)86:9<1856::AID-CNCR30>3.0.CO;2-G

Morley, 1998, Opioid rotation: does it have a role?, Palliative Medicine, 12, 464, 10.1177/026921639801200611

Moulin, 1988, Unidirectional analgesic cross-tolerance between morphine and levorphanol in the rat, Pain, 33, 233, 10.1016/0304-3959(88)90095-4

Noble, 1996, Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment, British Journal of Pharmacology, 117, 161, 10.1111/j.1476-5381.1996.tb15169.x

Ossipov, 2005, Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure, Biopolymers, 80, 319, 10.1002/bip.20254

Pasternak, 2001, Incomplete cross tolerance and multiple mu opioid peptide receptors, Trends in Pharmacological Sciences, 22, 67, 10.1016/S0165-6147(00)01616-3

Perry, 2002, Arresting developments in heptahelical receptor signaling and regulation, Trends in Cell Biology, 12, 130, 10.1016/S0962-8924(01)02239-5

Price, 1985, Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist, Anesthesia & Analgesia, 64, 801, 10.1213/00000539-198508000-00010

Quigley, 2004, Opioid switching to improve pain relief and drug tolerability, Cochrane Database of Systematic Reviews, 3, CD004847

Quirion, 1984, Pain, nociception and spinal opioid receptors, Progress in Neuro-psychopharmacology & Biological Psychiatry, 8, 571, 10.1016/0278-5846(84)90017-4

Quirion, 1983, Autoradiographic distribution of mu and delta opiate receptors in rat brain using highly selective ligands, Life Sciences, 33, 227, 10.1016/0024-3205(83)90484-8

Raehal, 2005, Mu opioid receptor regulation and opiate responsiveness, AAPS Journal, 7, E587, 10.1208/aapsj070360

Ross, 2006, Clinical pharmacology and pharmacotherapy of opioid switching in cancer patients, Oncologist, 11, 765, 10.1634/theoncologist.11-7-765

Ross, 2005, Clinical response to morphine in cancer patients and genetic variation in candidate genes, Pharmacogenomics Journal, 5, 324, 10.1038/sj.tpj.6500327

Saeki, 1993, Suppression of nociceptive responses by spinal mu opioid agonists: effects of stimulus intensity and agonist efficacy, Anesthesia & Analgesia, 77, 265, 10.1213/00000539-199308000-00010

Sander, 1998, Human mu-opioid receptor variation and alcohol dependence, AlcoholismClinical & Experimental Research, 22, 2108

Shen, 1990, Cholera toxin-A subunit blocks opioid excitatory effects on sensory neuron action potentials indicating mediation by Gs-linked opioid receptors, Brain Research, 525, 225, 10.1016/0006-8993(90)90868-C

Sim-Selley, 2000, Chronic heroin self-administration desensitizes mu opioid receptor–activated G-proteins in specific regions of rat brain, Journal of Neuroscience, 20, 4555, 10.1523/JNEUROSCI.20-12-04555.2000

Sim, 1996, Effects of chronic morphine administration on mu opioid receptor–stimulated [35S]GTPgammaS autoradiography in rat brain, Journal of Neuroscience, 16, 2684, 10.1523/JNEUROSCI.16-08-02684.1996

Sjogren, 1998, Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration? Six case histories, Acta Anaesthesiologica Scandinavica, 42, 1070, 10.1111/j.1399-6576.1998.tb05378.x

Sosnowski, 1990, Differential cross-tolerance between intrathecal morphine and sufentanil in the rat, Anesthesiology, 73, 1141, 10.1097/00000542-199012000-00012

Tang, 1984, Proglumide prevents and curtails acute tolerance to morphine in rats, Neuropharmacology, 23, 715, 10.1016/0028-3908(84)90171-0

Terman, 2004, G-Protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal, British Journal of Pharmacology, 141, 55, 10.1038/sj.bjp.0705595

Terner, 2006, Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains, Pain, 122, 90, 10.1016/j.pain.2006.01.019

Thomsen, 1999, Opioid rotation in chronic nonmalignant pain patients, Acta Anaesthesiologica Scandinavica, 43, 918, 10.1034/j.1399-6576.1999.430909.x

Town, 1999, Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency, American Journal of Medical Genetics, 88, 458, 10.1002/(SICI)1096-8628(19991015)88:5<458::AID-AJMG3>3.0.CO;2-S

Van Bockstaele, 1996, Ultrastructural evidence for prominent distribution of the mu-opioid receptor at extrasynaptic sites on noradrenergic dendrites in the rat nucleus locus coeruleus, Journal of Neuroscience, 16, 5037, 10.1523/JNEUROSCI.16-16-05037.1996

Vanderah, 2000, Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance, Journal of Neuroscience, 20, 7074, 10.1523/JNEUROSCI.20-18-07074.2000

Vanderah, 2001, Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance, Journal of Neuroscience, 21, 279, 10.1523/JNEUROSCI.21-01-00279.2001

Vigano, 1996, Individualized use of methadone and opioid rotation in the comprehensive management of cancer pain associated with poor prognostic indicators, Pain, 67, 115, 10.1016/0304-3959(96)03112-0

Wang, 2005, Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor–G protein coupling and Gbetagamma signaling, Neuroscience, 135, 247, 10.1016/j.neuroscience.2005.06.003

Watkins, 1984, Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide, Science, 224, 395, 10.1126/science.6546809

White, 2005, The changing role of nonopioid analgesic techniques in the management of postoperative pain, Anesthesia & Analgesia, 101, S5, 10.1213/01.ANE.0000177099.28914.A7

Xu, 1992, CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat, British Journal of Pharmacology, 105, 591, 10.1111/j.1476-5381.1992.tb09024.x

Yabaluri, 1997, Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling, Molecular Pharmacology, 52, 896, 10.1124/mol.52.5.896

Yoburn, 2003, Role of G(i)alpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo, Synapse, 47, 109, 10.1002/syn.10149