Mechanisms of Apoptosis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Kerr, 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, 26, 239, 10.1038/bjc.1972.33
Cryns, 1999, Proteases to die for, Genes Dev, 13, 371
Nicholson, 1996, ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis, Nat Biotechnol, 14, 297, 10.1038/nbt0396-297
Reed, 1998, Caspases and cytokines: roles in inflammation and autoimmunity, Adv Immunol, 73, 265, 10.1016/S0065-2776(08)60788-9
Salvesen, 1997, Caspases: intracellular signaling by proteolysis, Cell, 91, 443, 10.1016/S0092-8674(00)80430-4
Thornberry, 1997, A combinatorial approach defines specificities of members of the caspase family and granzyme B, J Biol Chem, 272, 17907, 10.1074/jbc.272.29.17907
Salvesen, 1999, Caspase activation: the induced-proximity model, Proc Natl Acad Sci USA, 96, 10964, 10.1073/pnas.96.20.10964
Wallach, 1999, Tumor necrosis factor receptor and Fas signaling mechanisms, Annu Rev Immunol, 17, 331, 10.1146/annurev.immunol.17.1.331
Yuan, 1997, Transducing signals of life and death, Curr Opin Cell Biol, 9, 247, 10.1016/S0955-0674(97)80069-5
Reed, 1997, Cytochrome c: can't live with it; can't live without it, Cell, 91, 559, 10.1016/S0092-8674(00)80442-0
Varfolomeev, 1998, Targeted disruption of the mouse caspase 8 gene ablates cell death inducation by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally, Immunity, 9, 267, 10.1016/S1074-7613(00)80609-3
Juo, 1998, Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade, Curr Biol, 8, 1001, 10.1016/S0960-9822(07)00420-4
Kuida, 1998, Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9, Cell, 94, 325, 10.1016/S0092-8674(00)81476-2
Hakem, 1998, Differential requirement for caspase 9 in apoptotic pathways in vivo, Cell, 94, 339, 10.1016/S0092-8674(00)81477-4
Chinnaiyan, 1995, FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis, Cell, 81, 505, 10.1016/0092-8674(95)90071-3
Boldin, 1995, A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain, J Biol Chem, 270, 7795, 10.1074/jbc.270.14.7795
Muzio, 1996, FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex, Cell, 85, 817, 10.1016/S0092-8674(00)81266-0
Boldin, 1996, Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death, Cell, 85, 803, 10.1016/S0092-8674(00)81265-9
Muzio, 1998, An induced proximity model for caspase-8 activation, J Biol Chem, 273, 2926, 10.1074/jbc.273.5.2926
Zou, 1997, Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3, Cell, 90, 405, 10.1016/S0092-8674(00)80501-2
Zou, 1999, An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9, J Biol Chem, 274, 11549, 10.1074/jbc.274.17.11549
Saleh, 1999, Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation, J Biol Chem, 274, 17941, 10.1074/jbc.274.25.17941
Li, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1
Stennicke, 1998, Pro-caspase-3 is a major physiologic target of caspase-8, J Biol Chem, 273, 27084, 10.1074/jbc.273.42.27084
Rodriguez, 1999, Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway, Nat Cell Biol, 1, 272, 10.1038/12984
Huang, 1996, NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain, Nature, 384, 638, 10.1038/384638a0
Liepinsh, 1997, NMR structure of the death domain of the p75 neurotrophin receptor, EMBO J, 16, 4999, 10.1093/emboj/16.16.4999
Bredesen, 1998, P75NTR and the concept of cellular dependence: seeing how the other half die, Cell Death Differ, 5, 365, 10.1038/sj.cdd.4400378
Hsu, 1995, The TNF receptor 1-associated protein TRADD signals cell death and NF-kappaB activation, Cell, 81, 495, 10.1016/0092-8674(95)90070-5
Chinnaiyan, 1996, Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95, Science, 274, 990, 10.1126/science.274.5289.990
Pan, 1998, Identification and functional characterization of DR6, a novel death domain-containing TNF receptor, FEBS Lett, 431, 351, 10.1016/S0014-5793(98)00791-1
Yeh, 1998, FADD essential for embryo development and signaling from some, but not all, inducers of apoptosis, Science, 279, 1954, 10.1126/science.279.5358.1954
Zhang, 1998, Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort 1, Nature, 392, 296, 10.1038/32681
Sprick, 2000, FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2, Immunity, 12, 599, 10.1016/S1074-7613(00)80211-3
Kischkel, 2000, Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5, Immunity, 12, 611, 10.1016/S1074-7613(00)80212-5
Ahmad, 1997, CRADD, a novel human apoptotic adaptor molecule for caspase-2 and FasL/tumor necrosis factor receptor-interacting protein RIP, Cancer Res, 57, 615
Levy-Strumpf, 1998, Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions, Oncogene, 17, 3331, 10.1038/sj.onc.1202588
Frisch, 1999, Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis, Curr Biol, 9, 1047, 10.1016/S0960-9822(99)80455-2
Rytomaa, 1999, Involvement of FADD and caspase-8 signaling in detachment-induced apoptosis, Curr Biol, 9, 1043, 10.1016/S0960-9822(99)80454-0
Stanger, 1995, RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death, Cell, 81, 513, 10.1016/0092-8674(95)90072-1
Hsu, 1996, TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex, Immunity, 4, 387, 10.1016/S1074-7613(00)80252-6
Ting, 1996, RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis, EMBO J, 15, 6189, 10.1002/j.1460-2075.1996.tb01007.x
Lee, 1999, NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes, Proc Natl Acad Sci USA, 96, 9136, 10.1073/pnas.96.16.9136
(Deleted in proof)
Stroka, 1999, Overexpression of A1: an NF-κB-inducible, anti-apoptotic Bcl gene that inhibits endothelial cell activation, Blood, 93, 3803, 10.1182/blood.V93.11.3803
Grumont, 1998, Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis, Genes Dev, 13, 400, 10.1101/gad.13.4.400
Stehlik, 1998, Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis, J Exp Med, 188, 211, 10.1084/jem.188.1.211
Stehlik, 1998, cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-κB, Biochem Biophys Res Commun, 243, 827, 10.1006/bbrc.1998.8185
Wang, 1998, NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress capase-8 activation, Science, 281, 1680, 10.1126/science.281.5383.1680
Antwerp, 1996, Suppression of TNF-α-induced apoptosis by NF-κB, Science, 274, 787, 10.1126/science.274.5288.787
Liu, 1996, Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death, Cell, 87, 565, 10.1016/S0092-8674(00)81375-6
Sabbatini, 1997, Interleukin 1β converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis, Cell Growth Differ, 8, 643
Jiang, 1999, Prevention of constitutive TNF receptor 1 signaling by silencer of death domains, Science, 283, 543, 10.1126/science.283.5401.543
Takayama, 1999, An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators, J Biol Chem, 274, 781, 10.1074/jbc.274.2.781
Tschopp, 1999, Apoptosis: silencing the death receptors, Curr Biol, 9, R381, 10.1016/S0960-9822(99)80233-4
Sato, 1995, FAP-1: A protein tyrosine phosphatase that associates with Fas, Science, 268, 411, 10.1126/science.7536343
Irie, 1999, Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75 and their effect on NF-kB activation, FEBS Lett, 460, 191, 10.1016/S0014-5793(99)01324-1
Yanagisawa, 1997, The molecular interaction of Fas and FAP-1: A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis, J Biol Chem, 272, 8539, 10.1074/jbc.272.13.8539
Myc, 1999, Characterization of FAP-1 expression and function in throid follicular cells, Endocrinology, 140, 5431, 10.1210/endo.140.11.7241
Tanaka, 1994, Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes, Circ Res, 75, 426, 10.1161/01.RES.75.3.426
Fisher, 1995, Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome, Cell, 81, 935, 10.1016/0092-8674(95)90013-6
Watanabe-Fukunaga, 1992, Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis, Nature, 356, 314, 10.1038/356314a0
Green, 1992, Activation-induced apoptosis in lymphoid systems, Semin Hematol, 4, 379
Wang, 1997, Molecules involved in cell death and peripheral tolerance, Curr Opin Immunol, 9, 818, 10.1016/S0952-7915(97)80184-7
Landowski, 1997, Mutations in the Fas antigen in patients with multiple myeloma, Blood, 90, 4266, 10.1182/blood.V90.11.4266
Cheng, 1994, Protection from fas-mediated apoptosis by a soluble form of the fas molecule, Science, 263, 1759, 10.1126/science.7510905
Hohlbaum, 2000, Opposing effects of transmembrane and soluble fas ligand expression on inflammation and tumor cell survival, J Exp Med, 191, 1209, 10.1084/jem.191.7.1209
Ashkenazi, 1999, Apoptosis control by death and decoy receptors, Curr Opin Cell Biol, 11, 255, 10.1016/S0955-0674(99)80034-9
Pan, 1997, An antagonist decoy receptor and a death domain-containing receptor for TRAIL, Science, 277, 815, 10.1126/science.277.5327.815
Pan, 1998, TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling, FEBS Lett, 424, 41, 10.1016/S0014-5793(98)00135-5
Sheridan, 1997, Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors (see comments), Science, 277, 818, 10.1126/science.277.5327.818
Gura, 1997, How TRAIL kills cancer cells, but not normal cells (news comment), Science, 277, 768, 10.1126/science.277.5327.768
Nagata, 2000, Steering anti-cancer drugs away from the TRAIL (news comment), Nat Med, 6, 502, 10.1038/74972
Eberstadt, 1998, NMR structure and mutagenesis of the FADD (Mort1) death-effector domain, Nature, 392, 941, 10.1038/31972
Stegh, 1998, DEDD, a novel death effector domain-containing protein, targeted to the nucleolus, EMBO J, 17, 5974, 10.1093/emboj/17.20.5974
Leo, 1998, DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells, Endocrinology, 139, 4839, 10.1210/endo.139.12.6335
Tschopp, 1998, Inhibition of Fas death signals by Flips, Curr Opin Immunol, 10, 552, 10.1016/S0952-7915(98)80223-9
French, 1999, Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors, J Exp Med, 190, 891, 10.1084/jem.190.7.891
O'Connell, 1996, The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand, J Exp Med, 184, 1075, 10.1084/jem.184.3.1075
Bennett, 1998, The Fas counterattack in vivo: apoptotic depletion of tumor-infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma, J Immunol, 160, 5669, 10.4049/jimmunol.160.11.5669
O'Connell, 1998, Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer, J Pathol, 186, 240, 10.1002/(SICI)1096-9896(199811)186:3<240::AID-PATH173>3.0.CO;2-L
Thome, 1997, Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors, Nature, 386, 517, 10.1038/386517a0
Tschopp, 1998, The fight of viruses against apoptosis, Curr Opin Genet Dev, 8, 82, 10.1016/S0959-437X(98)80066-X
Bertin, 1997, Death effector domain-containing herpesvirus and poxvirus proteins inhibit Fas-and TNFR1-induced apoptosis, Proc Natl Acad Sci USA, 94, 1172, 10.1073/pnas.94.4.1172
Wang, 1997, Bovine herpesvirus 4 BORFE2 protein inhibits Fas-and TNFR1-induced apoptosis and contains death effector domains shared with other gamma 2 herpesviruses, J Virol, 71, 8928, 10.1128/JVI.71.11.8928-8932.1997
Ng, 1997, p28 Bap31, a Bcl-2/Bcl-XL-and procaspase-8-associated protein in the endoplasmic reticulum, J Cell Biol, 39, 327, 10.1083/jcb.139.2.327
Zhang, 2000, BAR: an apoptosis regulator at the intersection of caspase and bcl-2 family proteins, Proc Natl Acad Sci USA, 97, 2597, 10.1073/pnas.97.6.2597
Rasper, 1998, Cell death attenuation by “Usurpin”, a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex, Cell Death Differ, 5, 271, 10.1038/sj.cdd.4400370
Li, 1995, Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock, Cell, 80, 401, 10.1016/0092-8674(95)90490-5
Bergeron, 1998, Defects in regulation of apoptosis in caspase-2-deficient mice, Genes Dev, 12, 1304, 10.1101/gad.12.9.1304
Wang, 1998, Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE, Cell, 92, 501, 10.1016/S0092-8674(00)80943-5
Bergeron, 1996, Sealing one's fate: control of cell death in neurons, Curr Opin Neurobiol, 8, 55, 10.1016/S0959-4388(98)80008-1
Ona, 1999, Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease (see comments), Nature, 399, 263, 10.1038/20446
Nakagawa, 2000, Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β, Nature, 403, 98, 10.1038/47513
Chou, 1998, Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment, Cell, 94, 171, 10.1016/S0092-8674(00)81417-8
Zhou, 1999, Solution structure of Apaf-1 CARD and its interation with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction, Proc Natl Acad Sci USA, 96, 11265, 10.1073/pnas.96.20.11265
Vaughn, 1999, Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling, J Mol Biol, 293, 439, 10.1006/jmbi.1999.3177
Day, 1999, Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1, Cell Death Differ, 6, 1125, 10.1038/sj.cdd.4400584
Koonin, 2000, The NACHT family: a new group of predicted NTPases implicated in apoptosis and MHC transcription activation, Trends Biol Sci, 25, 223, 10.1016/S0968-0004(00)01577-2
Seshagiri, 1997, Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis, Curr Biol, 7, 455, 10.1016/S0960-9822(06)00216-8
Yang, 1998, Essential role of CED-4 oligomerization in CED-3 activation and apoptosis, Science, 281, 1355, 10.1126/science.281.5381.1355
Abrams, 1999, An emerging blueprint for apoptosis in drosophila, Trends Cell Biol, 9, 435, 10.1016/S0962-8924(99)01646-3
Srinivasula, 1999, Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis, Cancer Res, 59, 999
Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science, 282, 1318, 10.1126/science.282.5392.1318
Saleh, 2000, Negative regulation of cytochrome c-mediated oligomerization of apaf-1 and activation of procaspase-9 by heat shock protein 90β, Nat Cell Biol, 2, 476, 10.1038/35019510
Beere, 2000, Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome, Nat Cell Biol, 2, 469, 10.1038/35019501
Matsuyama, 2000, Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis, Nat Cell Biol, 2, 318, 10.1038/35014006
Inohara, 1999, Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kB, J Biol Chem, 274, 14560, 10.1074/jbc.274.21.14560
Bertin, 1999, Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB, J Biol Chem, 274, 12955, 10.1074/jbc.274.19.12955
Yoshida, 1998, Apaf1 is required for mitochondrial pathways of apoptosis and brain development, Cell, 94, 739, 10.1016/S0092-8674(00)81733-X
Willis, 1999, Bcl10 is involved in t(1;14) (p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types, Cell, 96, 35, 10.1016/S0092-8674(00)80957-5
Koseki, 1999, CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10, J Biol Chem, 274, 9955, 10.1074/jbc.274.15.9955
Yan, 1999, mE10, a novel caspase recruitment domain-containing proapoptotic molecule, J Biol Chem, 275, 10287, 10.1074/jbc.274.15.10287
Zhang, 1999, Inactivating mutations and overexpression of BCL-10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32), Nat Genet, 22, 63, 10.1038/8767
Lee, 1999, Point mutations and deletions of the Bcl-10 gene in solid tumors and malignant lymphomas, Cancer Res, 59, 5674
Inohara, 1998, RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis, J Biol Chem, 273, 12296, 10.1074/jbc.273.20.12296
Thome, 1998, Identification of CARDIAK, a RIP-like kinase that assciates with caspase-1, Curr Biol, 16, 885, 10.1016/S0960-9822(07)00352-1
McCarthy, 1998, RIP2 is a novel NF-κB-activating and cell death-inducing kinase, J Biol Chem, 273, 16968, 10.1074/jbc.273.27.16968
Nolan, 1999, Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkB, Curr Biol, 9, 539, 10.1016/S0960-9822(99)80239-5
Deveraux, 1999, IAP family proteins: suppressors of apoptosis, Genes Dev, 13, 239, 10.1101/gad.13.3.239
LaCasse, 1998, The inhibitors of apoptosis (IAPs) and their emerging role in cancer, Oncogene, 17, 3247, 10.1038/sj.onc.1202569
Miller, 1999, An exegesis of IAPs: salvation and surprises from BIR motifs, Trends Cell Biol, 9, 323, 10.1016/S0962-8924(99)01609-8
Sun, 1999, NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP, Nature, 401, 818, 10.1038/44617
HInds, 1999, Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat, Nat Struct Biol, 6, 648, 10.1038/10701
Verdecia, 2000, Structure of the Human anti-apoptotic protein survivin reveals a dimeric arrangement, Nat Biotechnol, XX, 1
Yang, 2000, Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli, Science, 288, 874, 10.1126/science.288.5467.874
Hauser, 1998, A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors, J Cell Biol, 141, 1415, 10.1083/jcb.141.6.1415
Chen, 1999, A human IAP family gene, apollon, expressed in human brain cancer cells, Biochem Biophys Res Commun, 264, 847, 10.1006/bbrc.1999.1585
Fraser, 1999, Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis, Curr Biol, 9, 292, 10.1016/S0960-9822(99)80137-7
Vaux, 1999, Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division, Proc Natl Acad Sci Cell Biol, 96, 10170, 10.1073/pnas.96.18.10170
Deveraux, 1997, X-linked IAP is a direct inhibitor of cell death proteases, Nature, 388, 300, 10.1038/40901
Roy, 1997, The c-IAP-1 and c-IaP-2 proteins are direct inhibitors of specific caspases, EMBO J, 16, 6914, 10.1093/emboj/16.23.6914
Deveraux, 1999, Cleavage of human inhibitor of apoptosis protein xiap results in fragments with distinct specificities for caspases, EMBO J, 18, 5242, 10.1093/emboj/18.19.5242
Takahashi, 1998, A single BIR domain of XIAP sufficient for inhibiting caspases, J Biol Chem, 273, 7787, 10.1074/jbc.273.14.7787
Zhou, 1998, Interaction of the baculovirus antiapoptotic protein p35 with capases: specificity, kinetics, and characterization of the caspase/p35 complex, Biochemistry, 37, 10757, 10.1021/bi980893w
Deveraux, 1998, IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases, EMBO J, 17, 2215, 10.1093/emboj/17.8.2215
Huang, 2000, Evolutionary conservation of apoptosis mechanisms: Lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9, Proc Natl Acad Sci USA, 97, 1427, 10.1073/pnas.97.4.1427
Roy, 1995, The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy, Cell, 80, 167, 10.1016/0092-8674(95)90461-1
Ambrosini, 1997, A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma, Nat Med, 3, 917, 10.1038/nm0897-917
Adida, 1998, Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation, Am J Pathol, 152, 43
Li, 1998, Control of apoptosis and mitotic spindle checkpoint by survivin, Nature, 396, 580, 10.1038/25141
Li, 1999, Pleiotropic cell-division defects and apoptosis induced by interference with survivin function, Nat Cell Biol, 1, 461, 10.1038/70242
Li, 2000, Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast, J Biol Chem, 275, 6707, 10.1074/jbc.275.10.6707
Tamm, 2000, Expression and prognostic significance of iap family genes in human cancers and myeloid leukemias, Clin Cancer Res, 6, 1796
Steller, 1995, Mechanisms and genes of cellular suicide, Science, 267, 1445, 10.1126/science.7878463
Vucic, 1998, Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM, Mol Cell Biol, 18, 3300, 10.1128/MCB.18.6.3300
Wang, 1999, The drosophila caspase inhibitor diap1 is essential for cell survival and is negatively regulated by hid, Cell, 98, 453, 10.1016/S0092-8674(00)81974-1
Harvey, 1997, Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins, Mol Cell Biol, 17, 2835, 10.1128/MCB.17.5.2835
Goyal, 2000, Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function, EMBO J, 19, 589, 10.1093/emboj/19.4.589
Haining, 1999, The proapoptotic function of Drosophila Hid is conserved in mammalian cells, Proc Natl Acad Sci USA, 96, 4936, 10.1073/pnas.96.9.4936
Du, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8
Verhagen, 2000, Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins, Cell, 102, 43, 10.1016/S0092-8674(00)00009-X
Thress, 1998, Scythe: a novel reaper-binding apoptotic regulator, EMBO J, 17, 6135, 10.1093/emboj/17.21.6135
Adams, 1998, The Bcl-2 protein family: arbiters of cell survival, Science, 281, 1322, 10.1126/science.281.5381.1322
Gross, 1999, BCL-2 family members and the mitochondria in apoptosis, Genes Dev, 13, 1899, 10.1101/gad.13.15.1899
Kelekar, 1998, Bcl-2 family proteins: the role of the BH3 domain in apoptosis, Trends Cell Biol, 8, 324, 10.1016/S0962-8924(98)01321-X
Reed, 1996, Mechanisms of Bcl-2 family protein function and dysfunction in health and disease, Behring Inst Mitt, 97, 72
Tsujimoto, 1985, Involvement of the Bcl-2 gene in human follicular lymphoma, Science, 228, 1440, 10.1126/science.3874430
Weiss, 1987, Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas, N Engl J Med, 317, 1185, 10.1056/NEJM198711053171904
Reed, 1996, Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy, J Cell Biochem, 60, 23, 10.1002/(SICI)1097-4644(19960101)60:1<23::AID-JCB5>3.0.CO;2-5
Rampino, 1997, Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype, Science, 275, 967, 10.1126/science.275.5302.967
Yin, 1997, Bax suppresses tumorigenesis and stimulates apoptosis in vivo, Nature, 385, 637, 10.1038/385637a0
Miyashita, 1995, Tumor suppressor p53 is a direct transcriptional activator of human Bax gene, Cell, 80, 293, 10.1016/0092-8674(95)90412-3
Krajewski, 1995, Upregulation of Bax protein levels in neurons following cerebral ischemia, J Neurosci, 15, 6364, 10.1523/JNEUROSCI.15-10-06364.1995
Deckwerth, 1996, BAX is required for neuronal death after trophic factor deprivation and during development, Neuron, 17, 401, 10.1016/S0896-6273(00)80173-7
Miller, 1997, Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death, J Cell Biol, 139, 205, 10.1083/jcb.139.1.205
MacGibbon, 1997, Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimers disease hippocampus, Brain Res, 750, 223, 10.1016/S0006-8993(96)01351-0
Chen, 1996, bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations, Proc Natl Acad Sci USA, 93, 7042, 10.1073/pnas.93.14.7042
Middleton, 1996, Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors, Development, 122, 695, 10.1242/dev.122.2.695
Song, 1999, Boo, a novel negative regulator of cell death, interacts with Apaf-1, EMBO J, 18, 167, 10.1093/emboj/18.1.167
Inohara, 1998, Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death, J Biol Chem, 273, 32479, 10.1074/jbc.273.49.32479
Muchmore, 1996, X-ray and NMR structure of human Bcl-XL, an inhibitor of programmed cell death, Nature, 381, 335, 10.1038/381335a0
Chou, 1999, Solution structure of BID, an intracellular amplifier of apoptotic signaling, Cell, 96, 615, 10.1016/S0092-8674(00)80572-3
McDonnell, 1999, Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists, Cell, 96, 625, 10.1016/S0092-8674(00)80573-5
Schendel, 1998, Bcl-2 family proteins as ion-channels, Cell Death Differ, 5, 372, 10.1038/sj.cdd.4400365
Minn, 1997, Bcl-xL forms an ion channel in synthetic lipid membranes, Nature, 385, 353, 10.1038/385353a0
Schendel, 1997, Channel formation by antiapoptotic protein Bcl-2, Proc Natl Acad Sci USA, 94, 5113, 10.1073/pnas.94.10.5113
Antonsson, 1997, Inhibition of Bax channel-forming activity by Bcl-2, Science, 277, 370, 10.1126/science.277.5324.370
Schlesinger, 1997, Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2, Proc Natl Acad Sci USA, 94, 11357, 10.1073/pnas.94.21.11357
Schendel, 1999, Ion channel activity of the BH3 only Bcl-2 family member, BID, J Biol Chem, 274, 21932, 10.1074/jbc.274.31.21932
Sattler, 1997, Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis, Science, 275, 983, 10.1126/science.275.5302.983
Chen, 1997, The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis, J Exp Med, 186, 1975, 10.1084/jem.186.12.1975
Desagher, 1999, Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c depletion during apoptosis, J Cell Biol, 144, 891, 10.1083/jcb.144.5.891
Li, 1998, Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis, Cell, 94, 491, 10.1016/S0092-8674(00)81590-1
Luo, 1998, Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors, Cell, 94, 481, 10.1016/S0092-8674(00)81589-5
Yin, 1999, Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis, Nature, 400, 886, 10.1038/23730
Puthalakath, 1999, The proapoptotic activity of the Bcl-2 family member bim is regulated by interaction with the dynein motor complex, Mol Cell, 3, 287, 10.1016/S1097-2765(00)80456-6
Wang, 1998, Calcineurin promotes apoptosis by dephosphorylating BAD, Science, 284, 339, 10.1126/science.284.5412.339
Nechushtan, 1999, Conformation of the Bax C-terminus regulates subcellular location and cell death, EMBO J, 18, 2330, 10.1093/emboj/18.9.2330
Khaled, 1999, Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH, Proc Nat Acad Sci USA, 96, 14476, 10.1073/pnas.96.25.14476
Mancini, 1998, The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling, J Cell Biol, 140, 1485, 10.1083/jcb.140.6.1485
Krajewski, 1999, Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia, Proc Natl Acad Sci USA, 96, 5752, 10.1073/pnas.96.10.5752
Susin, 1999, Mitochondrial release of caspases-2 and -9 during the apoptotic process, J Exp Med, 189, 382, 10.1084/jem.189.2.381
Susin, 1999, Molecular characterisation of mitochondrial apoptosis-inducing factor (AIF), Nature, 397, 441, 10.1038/17135