Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice

Biochemical Pharmacology - Tập 39 Số 12 - Trang 2027-2034 - 1990
Philippe Lettéron1, G Labbe, Claude Degott, Alain Berson, Bernard Fromenty, M. Delaforge, Dominique Larrey, Dominique Pessayre
1Unité de Recherches de Physiopathologie Hépatique INSERM U-24, Hôpital Beaujon, Clichy, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Rauen, 1971, Die antihepatotoxische Wirkung von Silymarin bei experimentellen Leberschädigungen der Ratte durch Tetrachlorkohlenstoff, d-Galaktosamin und Allylalkohol, Arzneimittelforsch, 21, 1194

Hahn, 1968, Zur Pharmakologie und Toxikologie von Silymarin, des antihepatotoxischen Wirkprinzipes aus Silybum marianum (L.) Gaertn, Arzneimittelforsch, 18, 698

Rauen, 1973, Die antihepatotoxische Wirkung von parenteral verabreichtem Silymarin bei der Leberchädigung der Ratte durch CCl4, Arzneimittelforsch, 23, 148

Mourelle, 1989, Prevention of CCl4-induced cirrhosis by silymarin, Fund Clin Pharmacol, 3, 183, 10.1111/j.1472-8206.1989.tb00449.x

Floersheim, 1978, Experimentelle Grundlagen zur Therapie von Vergiftungen durch den grünen Knollenblätterpilz (Amanita phalloides), Schweiz Med Wochenschr, 108, 185

Schriewer, 1973, Die antihepatotoxische Wirkung des Silymarins bei der Leberschädigung durch Thioacetamid, Arzneimittelforsch, 23, 160

Bindoli, 1977, Inhibitory action of silymarin on lipid peroxide formation in rat liver mitochondria and microsomes, Biochem Pharmacol, 26, 2405, 10.1016/0006-2952(77)90449-X

Valenzuela, 1986, Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxideinduced microsomal lipid peroxidation, Experientia, 42, 139, 10.1007/BF01952435

Koch, 1985, Influence of silymarin and some flavonoids on lipid peroxidation in human platelets, Methods Find Exp Clin Pharmacol, 7, 13

Trinchet, 1989, Traitement de l'hépatite alcoolique par la silymarine. Une étude comparative en double insu chez 116 malades, Gastroenterol Clin Biol, 13, 120

Salmi, 1982, Effect of silymarin on chemical, functional, and morphological alterations of the liver, Scand J Gastroenterol, 17, 517, 10.3109/00365528209182242

Fintelmann, 1980, Nachweis der therapeutischen Wirksamkeit von Legalon® bei toxischen Lebererkrankungen im Doppelblindversuch, Therapiewoche, 30, 5589

Ferenci, 1989, Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver, J Hepatol, 9, 105, 10.1016/0168-8278(89)90083-4

Vogel, 1984, Protection by silibinin against Amanita phalloides intoxication in Beagles, Toxicol Appl Pharmacol, 73, 355, 10.1016/0041-008X(84)90087-5

Petzinger, 1979, Inhibition of 3H-demethylphalloin uptake in isolated rat hepatocytes under various experimental conditions, Naunyn Schmiedebergs Arch Pharmacol, 307, 275, 10.1007/BF00505944

Sonnenbichler, 1984, Undersuchungen zum Wirkungsmechanismus von Silibinin. V. Einfluss von Silibinin auf die Synthese Ribosomaler RNA, mRNA und tRNA in Rattenlebern in vivo, Hoppe Seilers Z Physiol Chem, 365, 555, 10.1515/bchm2.1984.365.1.555

Rauen, 1973, Silymarin verhindert die Lipidperoxidation bei der CCl4-Leberschädigung, Experientia, 29, 1372, 10.1007/BF01922826

McCay, 1984, Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro, J Biol Chem, 259, 2135, 10.1016/S0021-9258(17)43327-8

Reitman, 1957, A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Am J Clin Pathol, 28, 56, 10.1093/ajcp/28.1.56

Labbe, 1987, The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice, Biochem Pharmacol, 36, 907, 10.1016/0006-2952(87)90183-3

Hoellinger, 1985, In vitro covalent binding of cismethrin, bioresmethrin and their common alcohol to hepatic proteins, Toxicol Appl Pharmacol, 77, 11, 10.1016/0041-008X(85)90263-7

Lowry, 1951, Protein measurement with the Folin phenol reagent, J Biol Chem, 193, 265, 10.1016/S0021-9258(19)52451-6

Mazel, 1971, Experiments illustrating drug metabolism in vitro, 546

Kuntzman, 1966, Metabolism of drugs and carcinogens by human liver enzymes, J Pharmacol Exp Ther, 152, 151

Kupfer, 1973, A sensitive radioactive assay for hexobarbital hydroxylase in hepatic microsomes, Drug Metab Dispos, 1, 760

Greenlee, 1978, An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin, J Pharmacol Exp Ther, 205, 596

Pessayre, 1982, Hepatotoxicity of trichloroethylene-carbon tetrachloride mixtures in rats. A possible consequence of the potentiation by trichloroethylene of carbon tetrachloride-induced lipid peroxidation and liver lesions, Gastroemerology, 83, 761, 10.1016/S0016-5085(82)80004-8

Valenzuela, 1986, Antioxidant properties of the flavonoids silybin and (+)-cyanidanol-3: comparison with butylated hydroxy anisole and butylated hydroxytoluene, Planta Med, 6, 438, 10.1055/s-2007-969247