Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

North, K. Neurofibromatosis type 1. Am. J. Med. Genet. 97, 119–127 (2000)

Silva, A. J. et al. A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nature Genet. 15, 281–284 (1997)

Ballester, R. et al. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63, 851–859 (1990)

Xu, G. F. et al. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63, 835–841 (1990)

Guo, H. F., The, I., Hannan, F., Bernards, A. & Zhong, Y. Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 276, 795–798 (1997)

Guo, H. F., Tong, J., Hannan, F., Luo, L. & Zhong, Y. A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature 403, 895–898 (2000)

Xu, H. & Gutmann, D. H. Mutations in the GAP-related domain impair the ability of neurofibromin to associate with microtubules. Brain Res. 759, 149–152 (1997)

Ozonoff, S. Cognitive impairment in neurofibromatosis type 1. Am. J. Med. Genet. 89, 45–52 (1999)

Morris, R. G., Garrud, P., Rawlins, J. N. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681–683 (1982)

Costa, R. M. et al. Learning deficits, but normal development and tumour predisposition, in mice lacking exon 23a of Nf1. Nature Genet. 27, 399–405 (2001)

Klose, A. et al. Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1. Hum. Mol. Genet. 7, 1261–1268 (1998)

Johnson, L. K-r. et al. ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468–2481 (1997)

Brannan, C. I. et al. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8, 1019–1029 (1994)

Brandeis, R., Brandys, Y. & Yehuda, S. The use of the Morris water maze in the study of memory and learning. Int. J. Neurosci. 48, 29–69 (1989)

Gallagher, M., Burwell, R. & Burchinal, M. Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze. Behav. Neurosci. 107, 618–626 (1993)

Muthalif, M. M. et al. Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension. Hypertension 35, 457–463 (2000)

Gibbs, J. B. et al. Farnesyltransferase inhibitors versus Ras inhibitors. Curr. Opin. Chem. Biol. 1, 197–203 (1997)

Yan, N. et al. Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype. Cancer Res. 55, 3569–3575 (1995)

Kim, H. A., Ling, B. & Ratner, N. Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Mol. Cell. Biol. 17, 862–872 (1997)

Abbott, L. F. & Nelson, S. B. Synaptic plasticity: taming the beast. Nature Neurosci. 3, 1178–1183 (2000)

Larson, J., Wong, D. & Lynch, G. Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain Res. 368, 347–350 (1986)

Hessler, N. A., Shirke, A. M. & Malinow, R. The probability of transmitter release at a mammalian central synapse. Nature 366, 569–572 (1993)

Chapman, C. A., Perez, Y. & Lacaille, J. C. Effects of GABAA inhibition on the expression of long-term potentiation in CA1 pyramidal cells are dependent on tetanization parameters. Hippocampus 8, 289–298 (1998)

Chorvatova, A., Gendron, L., Bilodeau, L., Gallo-Payet, N. & Payet, M. D. A Ras-dependent chloride current activated by adrenocorticotropin in rat adrenal zona glomerulosa cells. Endocrinology 141, 684–692 (2000)

Tong, J. et al. NF1-regulated adenylyl cyclase pathway. Soc. Neurosci. Abstr. abstract no. 345.9 (Society for Neuroscience, New Orleans, 2000).

Ingram, D. A. et al. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J. Exp. Med. 194, 57–69 (2001)

Jacks, T. et al. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nature Genet. 7, 353–361 (1994)

Umanoff, H., Edelmann, W., Pellicer, A. & Kucherlapati, R. The murine N-ras gene is not essential for growth and development. Proc. Natl Acad. Sci. USA 92, 1709–1713 (1995)

Voikar, V., Koks, S., Vasar, E. & Rauvala, H. Strain and gender differences in the behaviour of mouse lines commonly used in transgenic studies. Physiol. Behav. 72, 271–281 (2001)

Blanton, M. G., Lo Turco, J. J. & Kriegstein, A. R. Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex. J. Neurosci. Methods 30, 203–210 (1989)