Mechanism and Regulation of NLRP3 Inflammasome Activation

Trends in Biochemical Sciences - Tập 41 Số 12 - Trang 1012-1021 - 2016
Yuan He1, Hideki Hara1, Gabriel Núñez1
1Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Franchi, 2012, Sensing and reacting to microbes through the inflammasomes, Nat. Immunol., 13, 325, 10.1038/ni.2231

Martinon, 2002, The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β, Mol. Cell, 10, 417, 10.1016/S1097-2765(02)00599-3

Wang, 2002, PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-κ B and caspase-1-dependent cytokine processing, J. Biol. Chem., 277, 29874, 10.1074/jbc.M203915200

Dinarello, 2009, Immunological and inflammatory functions of the interleukin-1 family, Annu. Rev. Immunol., 27, 519, 10.1146/annurev.immunol.021908.132612

Fink, 2006, Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages, Cell. Microbiol., 8, 1812, 10.1111/j.1462-5822.2006.00751.x

Lamkanfi, 2014, Mechanisms and functions of inflammasomes, Cell, 157, 1013, 10.1016/j.cell.2014.04.007

Man, 2015, Regulation of inflammasome activation, Immunol. Rev., 265, 6, 10.1111/imr.12296

Ting, 2008, The NLR gene family: a standard nomenclature, Immunity, 28, 285, 10.1016/j.immuni.2008.02.005

Franchi, 2009, Function of Nod-like receptors in microbial recognition and host defense, Immunol. Rev., 227, 106, 10.1111/j.1600-065X.2008.00734.x

Lamkanfi, 2012, Inflammasomes and their roles in health and disease, Annu. Rev. Cell Dev. Biol., 28, 137, 10.1146/annurev-cellbio-101011-155745

Strowig, 2012, Inflammasomes in health and disease, Nature, 481, 278, 10.1038/nature10759

Mariathasan, 2006, Cryopyrin activates the inflammasome in response to toxins and ATP, Nature, 440, 228, 10.1038/nature04515

Sha, 2014, Human NLRP3 inflammasome senses multiple types of bacterial RNAs, Proc. Natl Acad. Sci. U. S. A., 111, 16059, 10.1073/pnas.1412487111

Franchi, 2014, Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux, J. Immunol., 193, 4214, 10.4049/jimmunol.1400582

Dowling, 2012, Biochemical regulation of the inflammasome, Crit. Rev. Biochem. Mol. Biol., 47, 424, 10.3109/10409238.2012.694844

Bauernfeind, 2009, Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, J. Immunol., 183, 787, 10.4049/jimmunol.0901363

Harder, 2009, Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-κB activation but proceeds independently of TLR signaling and P2X7 receptor, J. Immunol., 183, 5823, 10.4049/jimmunol.0900444

Franchi, 2009, Cutting edge: TNF-α mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation, J. Immunol., 183, 792, 10.4049/jimmunol.0900173

Allam, 2014, Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming, EMBO Rep., 15, 982, 10.15252/embr.201438463

Gurung, 2014, FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes, J. Immunol., 192, 1835, 10.4049/jimmunol.1302839

Lemmers, 2007, Essential role for caspase-8 in Toll-like receptors and NFκB signaling, J. Biol. Chem., 282, 7416, 10.1074/jbc.M606721200

Schroder, 2012, Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction, Immunobiology, 217, 1325, 10.1016/j.imbio.2012.07.020

Juliana, 2012, Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation, J. Biol. Chem., 287, 36617, 10.1074/jbc.M112.407130

Fernandes-Alnemri, 2013, Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome, J. Immunol., 191, 3995, 10.4049/jimmunol.1301681

Lin, 2014, IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation, Proc. Natl Acad. Sci. U. S. A., 111, 775, 10.1073/pnas.1320294111

Py, 2013, Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity, Mol. Cell, 49, 331, 10.1016/j.molcel.2012.11.009

Lopez-Castejon, 2013, Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome, J. Biol. Chem., 288, 2721, 10.1074/jbc.M112.422238

Perregaux, 1994, Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity, J. Biol. Chem., 269, 15195, 10.1016/S0021-9258(17)36591-2

Piccini, 2008, ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1 beta and IL-18 secretion in an autocrine way, Proc. Natl Acad. Sci. U. S. A., 105, 8067, 10.1073/pnas.0709684105

Munoz-Planillo, 2013, K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter, Immunity, 38, 1142, 10.1016/j.immuni.2013.05.016

Petrilli, 2007, Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration, Cell Death Differ., 14, 1583, 10.1038/sj.cdd.4402195

Franchi, 2007, Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria, J. Biol. Chem., 282, 18810, 10.1074/jbc.M610762200

Yang, 2015, Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock, Immunity, 43, 923, 10.1016/j.immuni.2015.10.009

Ruhl, 2015, Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux, Eur. J. Immunol., 45, 2927, 10.1002/eji.201545772

Meng, 2009, A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses, Immunity, 30, 860, 10.1016/j.immuni.2009.04.012

Feldmeyer, 2007, The inflammasome mediates UVB-induced activation and secretion of interleukin-1β by keratinocytes, Curr. Biol., 17, 1140, 10.1016/j.cub.2007.05.074

Chu, 2009, Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner, J. Leukoc. Biol., 86, 1227, 10.1189/jlb.0309164

Brough, 2003, Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages, J. Immunol., 170, 3029, 10.4049/jimmunol.170.6.3029

Lee, 2012, The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP, Nature, 492, 123, 10.1038/nature11588

Murakami, 2012, Critical role for calcium mobilization in activation of the NLRP3 inflammasome, Proc. Natl Acad. Sci. U. S. A., 109, 11282, 10.1073/pnas.1117765109

Rossol, 2012, Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors, Nat. Commun., 3, 1329, 10.1038/ncomms2339

Katsnelson, 2015, K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling, J. Immunol., 194, 3937, 10.4049/jimmunol.1402658

Lawlor, 2014, Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?, Biochim. Biophys. Acta, 1840, 1433, 10.1016/j.bbagen.2013.08.014

Elliott, 2015, Initiation and perpetuation of NLRP3 inflammasome activation and assembly, Immunol. Rev., 265, 35, 10.1111/imr.12286

Dostert, 2008, Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica, Science, 320, 674, 10.1126/science.1156995

van Bruggen, 2010, Human NLRP3 inflammasome activation is Nox1-4 independent, Blood, 115, 5398, 10.1182/blood-2009-10-250803

Hornung, 2008, Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Nat. Immunol., 9, 847, 10.1038/ni.1631

Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663

Bauernfeind, 2011, Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome, J. Immunol., 187, 613, 10.4049/jimmunol.1100613

Shimada, 2012, Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Immunity, 36, 401, 10.1016/j.immuni.2012.01.009

Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol., 12, 222, 10.1038/ni.1980

Iyer, 2013, Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation, Immunity, 39, 311, 10.1016/j.immuni.2013.08.001

Subramanian, 2013, The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation, Cell, 153, 348, 10.1016/j.cell.2013.02.054

Park, 2013, The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity, J. Immunol., 191, 4358, 10.4049/jimmunol.1301170

Ermler, 2014, Rift Valley fever virus infection induces activation of the NLRP3 inflammasome, Virology, 449, 174, 10.1016/j.virol.2013.11.015

Halle, 2008, The NALP3 inflammasome is involved in the innate immune response to amyloid-beta, Nat. Immunol., 9, 857, 10.1038/ni.1636

Dostert, 2009, Malarial hemozoin is a Nalp3 inflammasome activating danger signal, PLoS One, 4, e6510, 10.1371/journal.pone.0006510

Orlowski, 2015, Multiple cathepsins promote pro-IL-1β synthesis and NLRP3-mediated IL-1β activation, J. Immunol., 195, 1685, 10.4049/jimmunol.1500509

Kayagaki, 2011, Non-canonical inflammasome activation targets caspase-11, Nature, 479, 117, 10.1038/nature10558

Rathinam, 2012, TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by Gram-negative bacteria, Cell, 150, 606, 10.1016/j.cell.2012.07.007

Gurung, 2012, Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens, J. Biol. Chem., 287, 34474, 10.1074/jbc.M112.401406

Meunier, 2014, Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases, Nature, 509, 366, 10.1038/nature13157

Kayagaki, 2013, Noncanonical inflammasome activation by intracellular LPS independent of TLR4, Science, 341, 1246, 10.1126/science.1240248

Hagar, 2013, Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock, Science, 341, 1250, 10.1126/science.1240988

Shi, 2014, Inflammatory caspases are innate immune receptors for intracellular LPS, Nature, 514, 187, 10.1038/nature13683

Shi, 2015, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death, Nature, 526, 660, 10.1038/nature15514

Kayagaki, 2015, Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling, Nature, 526, 666, 10.1038/nature15541

He, 2015, Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, Cell Res., 25, 1285, 10.1038/cr.2015.139

Ding, 2016, Pore-forming activity and structural autoinhibition of the gasdermin family, Nature, 535, 111, 10.1038/nature18590

Liu, 2016, Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores, Nature, 535, 153, 10.1038/nature18629

Aglietti, 2016, GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes, Proc. Natl Acad. Sci. U. S. A., 113, 7858, 10.1073/pnas.1607769113

Netea, 2009, Differential requirement for the activation of the inflammasome for processing and release of IL-1 beta in monocytes and macrophages, Blood, 113, 2324, 10.1182/blood-2008-03-146720

He, 2013, TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo, J. Immunol., 190, 334, 10.4049/jimmunol.1202737

Gaidt, 2016, Human monocytes engage an alternative inflammasome pathway, Immunity, 44, 833, 10.1016/j.immuni.2016.01.012

Shenoy, 2012, GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals, Science, 336, 481, 10.1126/science.1217141

Lu, 2012, Novel role of PKR in inflammasome activation and HMGB1 release, Nature, 488, 670, 10.1038/nature11290

He, 2016, NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux, Nature, 530, 354, 10.1038/nature16959

Shi, 2016, NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component, Nat. Immunol., 17, 250, 10.1038/ni.3333

Schmid-Burgk, 2016, A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation, J. Biol. Chem., 291, 103, 10.1074/jbc.C115.700492

He, 2013, The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages, Eur. J. Immunol., 43, 1147, 10.1002/eji.201243187

Fry, 2012, Cell cycle regulation by the NEK family of protein kinases, J. Cell Sci., 125, 4423, 10.1242/jcs.111195

Salem, 2010, Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy, Oncogene, 29, 4046, 10.1038/onc.2010.162