Manganese‐enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations

NMR in Biomedicine - Tập 17 Số 8 - Trang 532-543 - 2004
Afonso C. Silva1, Jeong Yong Lee1, Ichio Aoki2, Alan P. Koretsky1
1Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
2Department of Medical Informatics, Meiji University of Oriental Medicine, Kyoto, Japan

Tóm tắt

AbstractManganese‐enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connections in the brain; and to enhance the brain cytoarchitecture after a systemic dose. Based on an ever‐growing number of applications, MEMRI is proving useful as a new molecular imaging method to visualize functional neural circuits and anatomy as well as function in the brain in vivo. Paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest at an appropriate dose and in a time‐efficient manner. A major drawback to the use of Mn2+ as a contrast agent is its cellular toxicity. Therefore, it is critical to use as low a dose as possible. In the present work the different approaches to MEMRI are reviewed from a practical standpoint. Emphasis is given to the experimental methodology of how to achieve significant, yet safe, amounts of Mn2+ to the target areas of interest. Copyright © 2004 John Wiley & Sons, Ltd.

Từ khóa


Tài liệu tham khảo

10.1002/mrm.1910380305

LinYJ.MRI of the rat and mouse brain after systemic administration of MnCl2. Ph.D. Dissertation Carnegie Mellon University Pittsburgh PA 1997; 1–149.

10.1002/(SICI)1522-2594(200003)43:3<383::AID-MRM10>3.0.CO;2-Q

10.1002/mrm.10320

10.1002/mrm.1273

10.1148/radiol.2301020228

10.1002/mrm.1910400515

10.1006/nimg.2002.1075

10.1002/mrm.1209

10.1006/nimg.2001.0882

10.1667/0033-7587(2002)157[0500:NDORIO]2.0.CO;2

10.1002/nbm.834

10.1016/S0306-4522(02)00070-2

10.1016/S0896-6273(02)00718-3

10.1016/j.neuroimage.2004.03.031

10.1016/S0165-0270(02)00211-X

10.1002/mrm.10276

10.1196/annals.1306.018

10.1007/BF00570272

10.2214/ajr.141.1.193

Guyton AC, 1991, Textbook of Medical Physiology, 1

10.1016/j.autneu.2004.05.005

Desoize B, 2003, Metals and metal compounds in carcinogenesis, In Vivo, 17, 529

Lee JH, 2004, Manganese‐enhanced MRI (MEMRI) of mouse brain after systemic administration of MnCl2: dose dependent and temporal evolution of T 1 contrast, Magn. Reson. Med.

10.1016/S0001-2998(83)80048-8

10.1097/00004424-198704000-00008

10.1097/00004424-198409000-00012

10.1002/nbm.817

10.1002/mrm.20199

10.1097/00004424-199310000-00014

10.1002/mrm.1910020302

10.1016/B978-0-12-225401-7.50093-X

Hollis DP, 1978, Effect of manganese ion on phosphorus nuclear magnetic‐resonance spectra of perfused rabbit heart—possible new membrane probe, Clin. Res., 26, A240

10.1007/s003300050050

10.1002/1522-2586(200007)12:1<186::AID-JMRI21>3.0.CO;2-2

10.1002/(SICI)1522-2586(199911)10:5<694::AID-JMRI12>3.0.CO;2-J

10.1002/(SICI)1099-1492(199910)12:6<364::AID-NBM585>3.0.CO;2-Z

10.1148/radiology.216.2.r00jl14524

10.1002/mrm.1910350104

Barbeau A, 1984, Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C, Neurotoxicology, 5, 13

10.1016/0361-9230(89)90152-4

10.1002/mrm.1910210112

10.1016/0014-4886(89)90157-X

Lucchini R, 2000, Brain magnetic resonance imaging and manganese exposure, Neurotoxicology, 21, 769

Murphy VA, 1991, Elevation of brain manganese in calcium‐deficient rats, Neurotoxicology, 12, 255

10.1111/j.1471-4159.1993.tb02153.x

10.1016/0006-8993(94)90959-8

10.1016/S0006-8993(09)90032-4

10.1002/mrm.20047

10.1113/jphysiol.1984.sp015121

10.1016/0006-8993(90)91379-U

10.1016/0022-2828(81)90239-X

10.1016/0014-5793(85)80703-1

10.1016/0143-4160(93)90016-Y

Neuwelt EA, 1979, Osmotic blood‐brain barrier disruption: a new means of increasing chemotherapeutic agent delivery, Trans. Am. Neurol. Assoc., 104, 256

10.1002/mrm.1910370110

10.1016/S0304-3940(02)00330-0

10.1002/mrm.10528

10.1097/00004424-199710000-00001

10.1111/j.1600-0773.1996.tb00021.x

10.1002/mrm.10498

10.1111/j.1460-9568.2003.03056.x

10.1016/j.neuroimage.2003.10.007

Thông tin
Thông tin xuất bản

NMR in Biomedicine

Tập 17 Số 8

532-543

Thông tin tác giả