MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians

Suchita Markan1, M.P. Sachdeva1, B.S. Sehrawat1, Savita Kumari2, Sanjay Jain2, Madhu Khullar1
1Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Laboratory no. 2033, Research block B, Chandigarh, 160012, India
2Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Lim U, Cassano PA (2002) Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 156:1105–1113

Pierdomenico SD, Bucci A, Lapenna D, Lattanzio FM, Talone L, Cuccurullo F, Mezzetti A (2003) Circulating homocysteine levels in sustained and white coat hypertension. J Hum Hypertens 17:165–170

Rolland PH, Friggi A, Barlatier A, Piquet P, Latrille V, Faye MM, Guillou J, Charpiot P, Bodard H, Ghiringhelli O, Calaf R, Luccioni R, Garçon D (1995) Hyperhomocysteinemia-induced vascular damage in the mini pig: captopril-hydrochlorothiazide combination prevents elastic alterations. Circulation 91:1161–1174

Curgunlu A, Karter Y, Uzun H, Aydin S, Erturk N, Vehid S, Simsek G, Kutlu A, Ozturk E, Erdine S (2005) Hyperhomocysteinemia: an additional risk factor in white coat hypertension. Int Heart J 46:245–254

Jain S, Ram H, Kumari S, Khullar M (2003) Plasma homocysteine levels in Indian patients with essential hypertension and their siblings. Ren Fail 25:195–201

Mangoni AA, Sherwood RA, Swift CG, Jackson SH (2002) Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Intern Med 252:497–503

van Dijk RA, Rauwerda JA, Steyn M, Twisk JW, Stehouwer CD (2001) Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 21:2072–2079

Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, Palma RRJ, Boers GH, Sheahan RG, Israelsson B, Uiterwaal CS, Meleady R, McMaster D, Verhoef P, Witteman J, Rubba P, Bellet H, Wautrecht JC, de Valk HW, Sales LAC, Parrot RFM, Tan KS, Higgins I, Garcon D, Andria G (1997) Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 277:1775–1781

Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland M, Kvale G (1995) Total plasma homocysteine and cardiovascular risk profile: the Hordaland Homocysteine Study. JAMA 274:1526–1533

Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J (2001) Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 73:613–621

Kahleova R, Palyzova D, Zvara K, Zvarova J, Hrach K, Novakova I, Hyanek J, Bendlova B, Kozich V (2002) Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins. J Hypertens 15:857–864

Guldener VC, Nanayakkara PW, Stehouwer CD (2003) Homocysteine and blood pressure. Curr Hypertens Rep 5:26–31

Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuve LP, Rozen R (1995) A candidate genetic risk factor for vascular disease a common mutation in methyltetrahydrofolate reductase. Nat Genet 10:111–113

Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998) A second genetic polymorphism in methyltetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169–172

Weisberg IS, Jacques PF, Selhub J, Bostom AG, Chen Z, Curtis ER, Eckfeldt JH, Rozen R (2001) The 1298A > C polymorphism in methyltetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156:409–415

Heux S, Morin F, Lea RA, Ovcaric M, Tajouri L, Griffiths LR (2004) The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians. Hypertens Res 27:663–667

Koupepidou P, Deltas C, Christofides TC, Athanasiou Y, Zouvani I, Pierides A (2005) The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure. Int Angiol 24:287–294

Jiang S, Hsu YH, Niu T, Xu X, Xing H, Chen C, Wang X, Zhang Y, Peng S, Xu X (2005) A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients-a family-based association study. Clin Exp Hypertens 27:509–521

Lahiri DK, Nurnberger JI (1991) A rapid non-enzymatic method for the preparation of high molecular weight DNA from blood for RFLP studies. Nucleic Acids Res 355:523–527

Sundstrom J, Sullivan L, D’Agostino RB, Jacques PF, Selhub J, Rosenberg IH, Wilson PW, Levy D, Vasan RS (2003) Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham heart study. Hypertension 42:1100–1105

Rolland PH, Friggi A, Barlatier A, Piquet P, Latrille V, Faye MM, Guillou J, Charpiot P, Bodard H, Ghiringhelli O, Calaf R, Luccioni R, Garçon D (1995) Hyperhomocysteinemia-induced vascular damage in the minipig: captopril-hydrochlorothiazide combination prevents elastic alterations. Circulation 91:1161–1174

Hughes K, Ong CN (2000) Homocysteine, folate, vitamin B12, and cardiovascular risk in Indian, Malay, and Chinese in Singapore. J Epidemiol Community Health 54:31–34

Misra A, Vikram NK, Pandey RM, Dwivedi M, Ahmad FU, Luthra K, Jain K, Khanna N, Devi JR, Sharma R, Guleria R (2002) Hyperhomocysteinemia and low intakes of folic acid and vitamin B12 in urban North India. Eur J Nutr 41:68–77

Kostulas K, Crisby M, Huang WX, Lannfelt L, Hagenfeldt L, Eggertsen G, Kostulas V, Hillert J (1998) A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis. Eur J Clin Invest 28:285–289

Verhoef P, Kok FJ, Kluijtmans LA, Blom HJ, Refsum H, Ueland PM, Kruyssen DA (1997) The 677C > T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease. Atherosclerosis 132:105–113

Dedoussis GV, Panagiotakos DB, Chrysohoou C, Pitsavos C, Zampelas A, Choumerianou D, Stefanadis C (2004) Effect of interaction between adherence to a Mediterranean diet and the methylenetetrahydrofolate reductase 677C > T mutation on homocysteine concentrations in healthy adults: the ATTICA Study. Am J Clin Nutr 80:849–854

Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, Ogata J, Tomoike H, Ogihara T (2003) Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. Stroke 34:1628–1633

Benes P, Kankova K, Muzik J, Groch L, Benedik J, Elbl L, Izakovicova-Holla L, Vasku A, Znojil V, Vacha J (2001) Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population. J Mol Genet Metab 73:188–195

Friedman G, Goldschmidt N, Friedlander Y, Ben YA, Selhub J, Babaey S, Mendel M, Kidron M, Bar OH (1999) A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. J Nutr 129:1656–1661

Amero A, Khaled K, Wyngaard CA, Dzimiri N (2003) Prevalence and role of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in coronary artery disease in Arabs. Arch Pathol Lab Med 127:1349–1352

Angeline T, Jeyaraj N, Granito S, Tsongalis GJ (2004) Prevalence of MTHFR gene polymorphisms(C677T and A1298C) among Tamilians. Exp Mol Pathol 77:85–88

Lievers KJ, Boers GH, Verhoef P, Heijer DM, Kluijtmans LA, Put VNM, Trijbels FJ, Blom HJ (2001) A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med 79:522–528

Castro R, Rivera P, Ravasco C, Jacobs HJ, Blom ME, Camilo IT, Alemeida D (2003) 5, 10-Methylenetetrahydrofolate reductase 677C > T and1298A > C mutations are genetic determinants of elevated homocysteine. QJM 96:297–303

Williams C, Kingwell BA, Burke K, McPherson J, Dart AM (2005) Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr 82:26–31

Ogino S, Wilson RB (2003) Genotype and haplotype distributions of MTHFR677C > T and 1298A > C single nucleotide polymorphisms: a meta-analysis. J Hum Genet 48:1–7

Hernandez DS, Wu XF, Hayes C, Werler MM, Ashok TD, Badovinac R, Kelsey KT, Mitchell AA (2005) Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension. Epidemiology 16:628–634

Kumar J, Das SK, Sharma P, Karthikeyan G, Ramakrishnan L, Sengupta S (2005) Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population. J Hum Genet 50:655–663

Strauss E, Gluszek J, Pawlak AL (2005) Age and hypertension related changes in genotypes of MTHFR C677T, A1298C and PON1 −108C > T SNPs in men with coronary artery disease (CAD). J Physiol Pharmacol 56:65–75

Botto L, Yang Q (2000) 5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151:862–877

Volcik KA, Blanton SH, Northrup H (2001) Examinations of methylenetetrahydrofolate reductase C677T and A1298C mutations and in utero viability. Am J Hum Genet 69:1150–1153