MCC/IMS as potential noninvasive technique in the diagnosis of patients with COPD with and without alpha 1-antitrypsin deficiency

Rabe KF et al (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176:532–555 Bals R, Koczulla R, Kotke V, Andress J, Blackert K, Vogelmeier C (2007) Identification of individuals with alpha 1-antitrypsin deficiency by a targeted screening program. Respir Med 101:1708–1714 Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC, Cheung D, Bel EH, Sterk PJ (2009) Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med 180:1076–1082. doi:10.1164/rccm.200906-0939OC Moser B, Bodrogi F, Eibl G, Lechner M, Rieder J, Lirk P (2005) Mass spectrometric profile of exhaled breath-field study by PTR-MS. Respir Physiol Neurobiol 145:295–300. doi:10.1016/j.resp.2004.02.002 Thaler ER, Hanson CW (2005) Medical applications of electronic nose technology. Expert Rev Med Devices 2:559–566 Wewers MD, Gadek JE (1987) The protease theory of emphysema. Ann Intern Med 107:761–763 Bessa V, Darwiche K, Teschler H, Sommerwerck U, Rabis T, Baumbach JI, Freitag L (2011) Detection of volatile organic compounds (VOCs) in exhaled breath of patients with chronic obstructive pulmonary disease (COPD) by ion mobility spectrometry. Int J Ion Mobil Spectrom 14:7–13. doi:10.1007/s12127-011-0060-2 Westhoff M, Litterst P, Maddula S, Bödecker B, Rahmann S, Davies AN, Baumbach JI (2010) Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry. Int J Ion Mobil Spectrom 13:131–139 Jünger M, Bödeker B, Baumbach JI (2010) Peak assignment in multi-capillary column—ion mobility spectrometry using comparative studies with gas chromatography—mass spectrometry for exhaled breath analysis. Anal Bioanal Chem 396:471–482. doi:10.1007/s00216-009-3168-z Bödecker B, Davies AN, Maddula S, Baumbach JI (2010) Biomarker validation—room air variation during human breath investigations. Int J Ion Mobil Spectrom 13:177–184. doi:10.1007/s12127-010-0044-7 Westhoff M, Litterst P, Freitag L, Urfer W, Bader S, Baumbach JI (2009) Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study. Thorax 64:744–748. doi:10.1136/thx.2008.099465 Bunkowski A, Boedeker B, Bader S, Westhoff M, Litterst P, Baumbach JI (2009) MCC/IMS signals in human breath related to sarcoidosis-results of a feasibility study using an automated peak finding procedure. J Breath Res 3, 046001/046001-046001/046010 Baumbach JI (2009) Ion, mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath. J Breath Res 3:1–16 Ruzsanyi V, Baumbach JI (2005) Analysis of human breath using IMS. Int J Ion Mobil Spectrom 8:5–7 Ruzsanyi V, Baumbach JI, Sielemann S, Litterst P, Westhoff M, Freitag L (2005) Detection of human metabolites using multi-capillary columns coupled to ion mobility spectrometers. J Chromatogr A 1084:145–151 Basanta M et al (2010) Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst 135:315–320. doi:10.1039/b916374c Basanta M, Koimtzis T, Thomas CLP (2006) Sampling and analysis of exhaled breath on human subjects with thermal desorption gas chromatography—differential mobility spectrometry. Int J Ion Mobil Spectrom 9:45–49 Gooptu B, Ekeowa UI, Lomas DA (2009) Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights. Eur Respir J 34(2):475–488 Westhoff M, Litterst P, Freitag L, Baumbach JI (2007) Ion mobility spectrometry in the diagnosis of Sarcoidosis: Results of a feasibility study. J Physiol Pharmacol 58:739–751 Baumbach JI, Westhoff M (2006) Ion mobility spectrometry to detect lung cancer and airway infections. Spectrosc Eur 18:22–27 Baumbach JI (2006) Process, analysis using ion mobility spectrometry. Anal Bioanal Chem 384:1059–1070 Bunkowski A, Maddula S, Davies AN, Westhoff M, Litterst P, Bödecker B, Baumbach JI (2010) One-year time series of investigations of analytes within human breath using ion mobility spectrometry. Int J Ion Mobil Spectrom 13:141–148. doi:10.1007/s12127-010-0052-7 Maddula S, Blank L, Schmid A, Baumbach JI (2009) Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry. Anal Bioanal Chem 394:791–800 Bödeker B, Baumbach JI (2009) Analytical description of IMS-signals. Int J Ion Mobil Spectrom 12:103–108. doi:10.1007/s12127-009-0024-y Bödeker B, Vautz W, Baumbach JI (2008) Peak finding and referencing in MCC/IMS—Data. Int J Ion Mobil Spectrom 11:83–88 Bödeker B, Vautz W, Baumbach JI (2008) Peak comparison in MCC/IMS—Data—Searching for potential biomarkers in human breath data. Int J Ion Mobil Spectrom 11:89–93 Bödeker B, Vautz W, Baumbach JI (2008) Visualisation of MCC/IMS—Data. Int J Ion Mobil Spectrom 11:77–82