Low Ethanol Concentrations Selectively Augment the Tonic Inhibition Mediated by δ Subunit-Containing GABAAReceptors in Hippocampal Neurons

Journal of Neuroscience - Tập 24 Số 38 - Trang 8379-8382 - 2004
Weizheng Wei1, Leonardo Coutinho Faria, István Módy
1Department of Neurology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA.

Tóm tắt

In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by δ subunit-containing GABAAreceptors, this conductance is augmented by low concentrations (30 mm) of ethanol. In contrast, the tonic inhibition mediated by α5 subunit-containing receptors of CA1 pyramidal cells is not affected. The effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the δ subunit-dependent tonic inhibition as a likely site of ethanol action in the brain.

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Thông tin xuất bản

Journal of Neuroscience

Tập 24 Số 38

8379-8382

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