Loss of TGF-β1 Leads to Increased Neuronal Cell Death and Microgliosis in Mouse Brain

Alcantara, 1997, TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death, J. Neurosci., 17, 3623, 10.1523/JNEUROSCI.17-10-03623.1997

Bonyadi, 1997, Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice, Nat. Genet., 15, 207, 10.1038/ng0297-207

Buttini, 1998, Expression of human apolipoproteins E3 or E4 in brains of ApoE−/− mice, J. Neurosci., 19, 4867, 10.1523/JNEUROSCI.19-12-04867.1999

Chagraoui, 2001, Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos, Eur. Cytokine Netw., 12, 561

Chalazonitis, 1992, Transforming growth factor beta has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor, Dev. Biol., 152, 121, 10.1016/0012-1606(92)90162-A

Chen, 1997, Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin, Cell, 91, 917, 10.1016/S0092-8674(00)80483-3

Chen, 2001, TGF-β released by apoptotic T cells contributes to an immunosuppresive milieu, Immunity, 14, 715, 10.1016/S1074-7613(01)00147-9

Chin, 2002, Transforming growth factor β1 alters synapsin distribution and modulates synaptic depression in Aplysia, J. Neurosci., 22, 1, 10.1523/JNEUROSCI.22-09-j0004.2002

Dennler, 2002, Transforming growth factor β signal transduction, J. Leukoc. Biol., 71, 731, 10.1189/jlb.71.5.731

Dickson, 1995, Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice, Development, 121, 1845, 10.1242/dev.121.6.1845

Diebold, 1995, Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated, Proc. Natl. Acad. Sci. USA, 92, 12215, 10.1073/pnas.92.26.12215

Dünker, 2001, TGF-β modulates programmed cell death in the retina of the developing chick embryo, Development, 128, 1933, 10.1242/dev.128.11.1933

Ebendal, 1998, Bone morphogenetic proteins and their receptors, J. Neurosci. Res., 51, 139, 10.1002/(SICI)1097-4547(19980115)51:2<139::AID-JNR2>3.0.CO;2-E

Fadok, 1998, Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF, J. Clin. Invest., 101, 890, 10.1172/JCI1112

Fadok, 2000, A receptor for phosphatidylserine-specific clearance of apoptotic cells, Nature, 405, 85, 10.1038/35011084

Farkas, 2003, Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo, J. Neurosci., 23, 5178, 10.1523/JNEUROSCI.23-12-05178.2003

Finch, 1993, TGF-β1 is an organizer of responses to neurodegeneration, J. Cell. Biochem., 53, 314, 10.1002/jcb.240530408

Flanders, 1998, Transforming growth factor-βs in neurodegenerative disease, Prog. Neurobiol., 54, 71, 10.1016/S0301-0082(97)00066-X

Freire-de-Lima, 2000, Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages, Nature, 403, 199, 10.1038/35003208

Geiser, 1993, Transforming growth factor β1 (TGF-β1) controls expression of major histocompatibility genes in the postnatal mouse, Proc. Natl. Acad. Sci. USA, 90, 9944, 10.1073/pnas.90.21.9944

Gleeson, 1998, Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein, Cell, 92, 63, 10.1016/S0092-8674(00)80899-5

Grainger, 1999, Genetic control of the circulating concentration of transforming growth factor type β1, Hum. Mol. Genet., 8, 93, 10.1093/hmg/8.1.93

Hecker, 1996, High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR, Biotechniques, 20, 478, 10.2144/19962003478

Huang, 2001, Neurotrophins, Annu. Rev. Neurosci., 24, 677, 10.1146/annurev.neuro.24.1.677

Indyk, 2003, Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury, Neuroscience, 116, 359, 10.1016/S0306-4522(02)00704-2

Johnson, 1993, Molecular mechanisms of developmental neuronal death, Annu. Rev. Neurosci., 16, 31, 10.1146/annurev.ne.16.030193.000335

Jones, 1994, Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development, Cell, 76, 989, 10.1016/0092-8674(94)90377-8

Kim, 1990, Autoinduction of transforming growth factor β1 is mediated by the AP-1 complex, Mol. Cell. Biol., 10, 1492

Krieglstein, 1998, Transforming growth factor-β mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons, Eur. J. Neurosci., 10, 2746

Krieglstein, 2000, Reduction of endogenous transforming growth factors beta prevents ontogenetic neuron death, Nat. Neurosci., 3, 1085, 10.1038/80598

Kulkarni, 1993, Transforming growth factor-β1 null mutation in mice causes excessive inflammatory response and early death, Proc. Natl. Acad. Sci. USA, 90, 770, 10.1073/pnas.90.2.770

Letterio, 2000, Murine models define the role of TGF-β as a master regulator of immune cell function, Cytokine Growth Factor Rev., 11, 81, 10.1016/S1359-6101(99)00031-3

Letterio, 1997, TGF-beta, Clin. Immunol. Immunopathol., 84, 244, 10.1006/clin.1997.4409

Letterio, 1998, Regulation of immune responses by TGF-beta, Annu. Rev. Immunol., 16, 137, 10.1146/annurev.immunol.16.1.137

Letterio, 1996, Autoimmunity associated with TGF-β1 deficiency in mice is dependent on MHC class II antigen expression, J. Clin. Invest., 98, 2109, 10.1172/JCI119017

Longenecker, 2002, Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype, Cytokine, 18, 43, 10.1006/cyto.2002.1025

Loskutoff, 1989, Type 1 plasminogen activator inhibitor, Prog. Hemost. Thromb., 9, 87

Luckenbill-Edds, 1997, Laminin and the mechanism of neuronal outgrowth, Brain Res. Brain Res. Rev., 23, 1, 10.1016/S0165-0173(96)00013-6

Masliah, 1992, Spectrum of human immunodeficiency virus-associated neocortical damage, Ann. Neurol., 32, 321, 10.1002/ana.410320304

Masliah, 1992, Cortical dendritic pathology in human immunodeficiency virus encephalitis, Lab. Invest., 66, 285

Masliah, 1995, Neurodegeneration in the central nervous system of apoE-deficient mice, Exp. Neurol., 136, 107, 10.1006/exnr.1995.1088

Massagué, 2000, TGF-β signaling in growth control, cancer, and heritable disorders, Cell, 103, 295, 10.1016/S0092-8674(00)00121-5

McCartney-Francis, 1994, Transforming growth factor β, J. Leukoc. Biol., 55, 401, 10.1002/jlb.55.3.401

Mehler, 1997, Bone morphogenetic proteins in the nervous system, Trends Neurosci., 20, 309, 10.1016/S0166-2236(96)01046-6

Minichiello, 1996, TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons, Genes Dev., 10, 2849, 10.1101/gad.10.22.2849

Mombaerts, 1992, RAG-1-deficient mice have no mature B and T lymphocytes, Cell, 68, 869, 10.1016/0092-8674(92)90030-G

Munger, 1997, Latent transforming growth factor-β, Kidney Int., 51, 1376, 10.1038/ki.1997.188

Roberts, 1996, Transforming growth factor-β, 275

Rothman, 1995, Excitotoxicity and the NMDA receptor—still lethal after eight years, Trends Neurosci., 18, 57

Schauwecker, 1997, Genetic determinants of susceptibility to excitotoxic cell death, Proc. Natl. Acad. Sci. USA, 94, 4103, 10.1073/pnas.94.8.4103

Schober, 1999, Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-β as cofactor in vivo, J. Neurosci., 19, 2008, 10.1523/JNEUROSCI.19-06-02008.1999

Shull, 1992, Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease, Nature, 359, 693, 10.1038/359693a0

Sometani, 2001, Transforming growth factor-beta1 enhances expression of brain-derived neurotrophic factor and its receptor, TrkB, in neurons cultured from rat cerebral cortex, J. Neurosci. Res., 66, 369, 10.1002/jnr.1229

Sweeney, 2002, Unrestricted synaptic growth in spinster—a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation, Neuron, 36, 403, 10.1016/S0896-6273(02)01014-0

Terry, 1991, Physical basis of cognitive alterations in Alzheimer's disease, Ann. Neurol., 30, 572, 10.1002/ana.410300410

Tesseur, 2000, Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord, Am. J. Pathol., 157, 1495, 10.1016/S0002-9440(10)64788-8

Tsirka, 1996, Neuronal cell death and tPA, Nature, 384, 123, 10.1038/384123b0

Unsicker, 2000, Co-activation of TGF-β and cytokine signaling pathways are required for neurotrophic functions, Cytokine Growth Factor Rev., 11, 97, 10.1016/S1359-6101(99)00033-7

Unsicker, 2002, TGF-betas and their roles in the regulation of neuron survival, Adv. Exp. Med. Biol., 513, 353, 10.1007/978-1-4615-0123-7_13

Venstrom, 1993, Extracellular matrix. 2, FASEB J., 7, 996, 10.1096/fasebj.7.11.8370483

Weinstein, 2000, Functions of mammalian Smad genes as revealed by targeted gene disruption in mice, Cytokine Growth Factor Rev., 11, 49, 10.1016/S1359-6101(99)00028-3

Wyss-Coray, 1995, Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-β1, Am. J. Pathol., 147, 53

Wyss-Coray, 2000, Chronic overproduction of TGF-β1 in astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice, Am. J. Pathol., 156, 139, 10.1016/S0002-9440(10)64713-X

Wyss-Coray, 2001, TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice, Nat. Med., 7, 614, 10.1038/87945

Xu, 2000, Cortical degeneration in the absence of neurotrophin signaling, Neuron, 26, 233, 10.1016/S0896-6273(00)81153-8

Zhang, 1997, Role of transforming growth factor-β in long-term synaptic facilitation in Aplysia, Science, 275, 1318, 10.1126/science.275.5304.1318

Zheng, 2003, TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain, Cell, 112, 303, 10.1016/S0092-8674(03)00072-2