Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Aging Cell - Tập 15 Số 5 - Trang 872-884 - 2016
Randy Strong1,2, Richard A. Miller3, Adam Antebi4, Clinton M. Astle5, Molly A. Bogue5, Martin S. Denzel4, Elizabeth Fernández1,2, Kevin Flurkey5, Karyn L. Hamilton6, Dudley W. Lamming7, Martin A. Javors8, João Pedro de Magalhães9, Paul Anthony Martinez1,2, Joe M. McCord10, Benjamin F. Miller6, Michael Müller11, James F. Nelson12, Juliet Ndukum5, G. Ed Rainger13, Arlan Richardson14,15, David M. Sabatini16,17,18,19,20, Adam B. Salmon21, James W. Simpkins22, Wilma T. Steegenga23, Nancy L. Nadon24, David E. Harrison5
1Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
2Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA
3Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109-2200 USA
4Max Planck Institute for Biology of Ageing, Cologne D-50931, Germany;
5The Jackson Laboratory, Bar Harbor, ME 04609, USA
6Colorado State University, Fort Collins, CO 80523, USA
7Department of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA
8Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
9School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
10Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA
11Norwich Medical School, University of East Anglia, Norwich, UK
12Department of Physiology and Barshop Center for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA
13Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, The Medical School, The University of Birmingham, Birmingham, UK
14Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
15VA Medical Center, Oklahoma City, OK, 73104 USA
16Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, MA, 02142 USA
17Department of Biology, MIT, Cambridge, MA 02139, USA
18Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA
19The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA
20Whitehead Institute for Biomedical Research, Cambridge, MA 02142 USA
21Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 USA
22Center for Basic & Translational Stroke Research, West Virginia University, Morgantown, WV, 26506 USA
23Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands
24Division of Aging Biology, National Institute on Aging, Bethesda, MD, 20892 USA

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