LncRNA MEG3 overexpression inhibits the development of diabetic retinopathy by regulating TGF‑β1 and VEGF

Daning Zhang1, Haixiang Qin2, Ying Leng1, Xiangjun Li1, Lei Zhang1, Dan Bai1, Meng Yu-jun1, Jingyi Wang1
1Department of Ophthalmology, Affiliated Hospital of Beihua University, Jilin 132011, P.R. China
2Department of Legal Medical Experts, Public Security Bureau of Jilin City, Jilin 132011, P.R. China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Imamura, 2015, Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: Systematic review, meta-analysis, and estimation of population attributable fraction, BMJ, 351, h3576, 10.1136/bmj.h3576

Nathan, 2014, The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Overview, Diabetes Care, 37, 9, 10.2337/dc13-2112

Leasher, 2016, Global estimates on the number of people blind or visually impaired by diabetic retinopathy: A meta-analysis from 1990 to 2010, Diabetes Care, 39, 1643, 10.2337/dc15-2171

Kertes, 2007, Evidence-based eye care

Tapp, 2003, The prevalence of and factors associated with diabetic retinopathy in the Australian population, Diabetes Care, 26, 1731, 10.2337/diacare.26.6.1731

Perkel, 2013, Visiting ‘noncodarnia’, Biotechniques, 54, 301, 303, 10.2144/000114037

Hung, 2010, Long noncoding RNA in genome regulation: prospects and mechanisms, RNA Biol, 7, 582, 10.4161/rna.7.5.13216

Yang, 2014, LncRNA: A link between RNA and cancer, Biochim Biophys Acta, 1839, 1097, 10.1016/j.bbagrm.2014.08.012

Kumarswamy, 2014, Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure, Circ Res, 114, 1569, 10.1161/CIRCRESAHA.114.303915

Jaé, 2015, Long noncoding RNAs in diabetic retinopathy, Circ Res, 116, 1104, 10.1161/CIRCRESAHA.115.306051

Qin, 2013, Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis, Neoplasma, 60, 486, 10.4149/neo_2013_063

Zhou, 2012, MEG3 noncoding RNA: A tumor suppressor, J Mol Endocrinol, 48, R45, 10.1530/JME-12-0008

Ha, 2001, High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells, Kidney Int, 59, 463, 10.1046/j.1523-1755.2001.059002463.x

Guariguata, 2014, Global estimates of diabetes prevalence for 2013 and projections for 2035, Diabetes Res Clin Pract, 103, 137, 10.1016/j.diabres.2013.11.002

Lopez-Galvez, 2014, Diabetic retinopathy: An overview, Handbook of Nutrition, Diet and the Eye, 41, 10.1016/B978-0-12-401717-7.00005-8

Thomas, 2017, ANRIL: A Regulator of VEGF in Diabetic Retinopathy, Invest Ophthalmol Vis Sci, 58, 470, 10.1167/iovs.16-20569

Liu, 2017, Downregulation of the long non-coding RNA Meg3 promotes angiogenesis after ischemic brain injury by activating notch signaling, Mol Neurobiol, 54, 8179, 10.1007/s12035-016-0270-z

Simó, 2014, Ocular anti-VEGF therapy for diabetic retinopathy: The role of VEGF in the pathogenesis of diabetic retinopathy, Diabetes Care, 37, 893, 10.2337/dc13-2002

Goldfarb, 2001, TGF-beta: A crucial component of the pathogenesis of diabetic nephropathy, Trans Am Clin Climatol Assoc, 112, 27

Su, 2015, The long noncoding RNA MEG3 is downregulated and inversely associated with VEGF levels in osteoarthritis, Biomed Res Int, 2015, 356893, 10.1155/2015/356893

Mondal, 2015, MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures, Nat Commun, 6, 7743, 10.1038/ncomms8743