Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting

Pulmonary Medicine - Tập 2012 - Trang 1-6 - 2012
Iukary Takenami1, Brook Finkmoore2, Almério Machado3,4, Krisztina Emodi2, Lee W. Riley2, Sérgio Arruda1,3
1Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Salvador, Bahia 40296 710, Brazil
2Division of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA
3Bahia School of Medicine and Public Health, Salvador, Bahia 40290 000, Brazil
4Hospital Especializado Octávio Mangabeira, Secretary of Health of Bahia State, Salvador, Bahia 40320 350, Brazil

Tóm tắt

Objectives. We investigated IFN-γlevels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting.Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γresponse toMycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared.Results. Of the 26 study participants, 25 (96%) showed an IFN-γlevel higher than their baseline level before treatment (P≤0.001). Only one individual had a decreased IFN-γlevel after treatment but remained positive for LTBI.Conclusion. In a high-transmission setting, the IFN-γlevel has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.

Từ khóa


Tài liệu tham khảo

2000, The Lancet, 356, 1099, 10.1016/S0140-6736(00)02742-2

10.1016/S1473-3099(04)01206-X

10.1016/j.diagmicrobio.2008.01.002

2008, Annals of Internal Medicine, 149, 177, 10.7326/0003-4819-149-3-200808050-00241

10.1186/1471-2334-6-66

10.1016/j.jinf.2008.08.009

10.1371/journal.pone.0005187

10.1016/j.rmed.2008.09.012

10.1186/1471-2334-9-23

10.1186/1745-6673-1-7

10.1111/j.1440-1843.2008.01244.x

10.1007/s10096-008-0670-8

10.1086/381754

10.1086/381763

10.1086/499311

10.1186/1465-9921-8-5

2004, Jornal Brasileiro de Pneumologia, 30, S2, 10.1590/S1806-37132004000100003

2009, International Journal of Tuberculosis and Lung Disease, 13, 446

2009, International Journal of Tuberculosis and Lung Disease, 13, 719

10.1016/S0966-842X(98)01216-5

2007, The International Journal of Tuberculosis and Lung Disease, 11, 282

2001, Canadian Journal of Infectious Diseases, 12, 211, 10.1155/2001/616419

10.1164/rccm.200511-1783OC

10.1016/S0369-8114(03)00098-1

10.1183/09031936.00117506

10.1164/rccm.200811-1704OC

10.1371/journal.pone.0008517

10.1016/j.cyto.2008.04.011

10.1164/rccm.200205-438BC

Thông tin
Thông tin xuất bản

Pulmonary Medicine

Tập 2012

1-6

Thông tin tác giả