Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

Molecular Metabolism - Tập 3 Số 7 - Trang 681-693 - 2014
Kavon Rezai‐Zadeh1, Sangho Yu1, Yanyan Jiang2, Amanda Laque1, Candice Schwartzenburg1, Christopher D. Morrison3, Andrei V. Derbenev2, Andrea Zsombok2, Heike Münzberg1
1Central Leptin Signaling, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.
2Department of Physiology; School of Medicine; Tulane University; New Orleans LA USA
3Neurosignaling, Pennington Biomedical Research Center (PBRC), LSU System, Baton Rouge, LA, USA.

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Haynes, 1997, Receptor-mediated regional sympathetic nerve activation by leptin, Journal of Clinical Investigation, 100, 270, 10.1172/JCI119532

Richards, 2003, Leptin: sympathetic and cardiovascular effects, Current Cardiology Reports, 5, 453, 10.1007/s11886-003-0106-0

Gavrilova, 1999, Torpor in mice is induced by both leptin-dependent and -independent mechanisms, Proceedings of the National Academy of Sciences of the United States of America, 96, 14623, 10.1073/pnas.96.25.14623

Davis, 1954, Imperfect homeothermia in the hereditary obese-hyperglycemic syndrome of mice, American Journal of Physiology, 177, 222, 10.1152/ajplegacy.1954.177.2.222

Joosten, 1974, Role of the thyroid in the development of the obese-hyperglycemic syndrome in mice (ob ob), Metabolism, 23, 425, 10.1016/0026-0495(74)90090-0

Himms-Hagen, 1985, Defective brown adipose tissue thermogenesis in obese mice, International Journal of Obesity, 9, 17

Commins, 2001, Leptin selectively reduces white adipose tissue in mice via a UCP1-dependent mechanism in brown adipose tissue, American Journal of Physiology. Endocrinology and Metabolism, 280, E372, 10.1152/ajpendo.2001.280.2.E372

Heymsfield, 1999, Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial, Journal of the American Medical Association, 282, 1568, 10.1001/jama.282.16.1568

Frederich, 1995, Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action, Nature Medicine, 1, 1311, 10.1038/nm1295-1311

Rosenbaum, 2005, Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight, Journal of Clinical Investigation, 115, 3579, 10.1172/JCI25977

Galgani, 2010, Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients, Journal of Clinical Endocrinology and Metabolism, 95, 851, 10.1210/jc.2009-1739

Gilsanz, 2011, Functional brown adipose tissue is related to muscle volume in children and adolescents, Journal of Pediatrics, 158, 722, 10.1016/j.jpeds.2010.11.020

Wang, 2011, Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity, PLoS ONE, 6, e21006, 10.1371/journal.pone.0021006

Morrison, 2008, Central control of thermogenesis in mammals, Experimental Physiology, 93, 773, 10.1113/expphysiol.2007.041848

Nagashima, 2000, Neuronal circuitries involved in thermoregulation, Autonomic Neuroscience, 85, 18, 10.1016/S1566-0702(00)00216-2

Dimicco, 2007, The dorsomedial hypothalamus: a new player in thermoregulation, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 292, R47, 10.1152/ajpregu.00498.2006

Yoshida, 2009, Parallel preoptic pathways for thermoregulation, Journal of Neuroscience, 29, 11954, 10.1523/JNEUROSCI.2643-09.2009

Zhang, 2011, Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits, Journal of Neuroscience, 31, 1873, 10.1523/JNEUROSCI.3223-10.2011

Enriori, 2011, Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance, Journal of Neuroscience, 31, 12189, 10.1523/JNEUROSCI.2336-11.2011

McMinn, 2004, An allelic series for the leptin receptor gene generated by CRE and FLP recombinase, Mammalian Genome, 15, 677, 10.1007/s00335-004-2340-1

van de Wall, 2008, Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion, Endocrinology, 149, 1773, 10.1210/en.2007-1132

Leshan, 2006, Leptin receptor signaling and action in the central nervous system, Obesity (Silver Spring), 14, 208S, 10.1038/oby.2006.310

Faouzi, 2007, Differential accessibility of circulating leptin to individual hypothalamic sites, Endocrinology, 148, 5414, 10.1210/en.2007-0655

Paxinos, 2004

Laque, 2013, Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action, American Journal of Physiology. Endocrinology and Metabolism, 304, E999, 10.1152/ajpendo.00643.2012

Gao, 2012, Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse, Diabetes, 61, 1381, 10.2337/db11-0820

Jiang, 2013, Reduced GABAergic inhibition of kidney-related PVN neurons in streptozotocin-treated type 1 diabetic mouse, Journal of Neurophysiology, 110, 2192, 10.1152/jn.00013.2013

Nakamura, 2005, Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus, European Journal of Neuroscience, 22, 3137, 10.1111/j.1460-9568.2005.04515.x

Zaretskaia, 2008, Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamus, Brain Research, 1200, 39, 10.1016/j.brainres.2008.01.018

Alexander, 2009, Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors, Neuron, 63, 27, 10.1016/j.neuron.2009.06.014

Krashes, 2011, Rapid, reversible activation of AgRP neurons drives feeding behavior in mice, Journal of Clinical Investigation, 121, 1424, 10.1172/JCI46229

Wulff, 2012, Chemical genetics: receptor-ligand pairs for rapid manipulation of neuronal activity, Current Opinion in Neurobiology, 22, 54, 10.1016/j.conb.2011.10.008

Balthasar, 2004, Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis, Neuron, 42, 983, 10.1016/j.neuron.2004.06.004

Coppari, 2005, The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity, Cell Metabolism, 1, 63, 10.1016/j.cmet.2004.12.004

Dhillon, 2006, Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis, Neuron, 49, 191, 10.1016/j.neuron.2005.12.021

Leinninger, 2009, Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding, Cell Metabolism, 10, 89, 10.1016/j.cmet.2009.06.011

Hommel, 2006, Leptin receptor signaling in midbrain dopamine neurons regulates feeding, Neuron, 51, 801, 10.1016/j.neuron.2006.08.023

Rothwell, 1983, Diet-induced thermogenesis, Advances in Nutritional Research, 5, 201, 10.1007/978-1-4613-9937-7_9

Nava, 1990, Cold-induced and diet-induced thermogenesis in progesterone-treated rats, Pflugers Archiv, 415, 747, 10.1007/BF02584015

Himms-Hagen, 1989, Role of thermogenesis in the regulation of energy balance in relation to obesity, Canadian Journal of Physiology and Pharmacology, 67, 394, 10.1139/y89-063

Crescenzo, 2003, A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth, Diabetes, 52, 1090, 10.2337/diabetes.52.5.1090

Harris, 1998, A leptin dose-response study in obese (ob/ob) and lean (+/?) mice, Endocrinology, 139, 8, 10.1210/endo.139.1.5675

Pelleymounter, 1995, Effects of the obese gene product on body weight regulation in ob/ob mice, Science, 269, 540, 10.1126/science.7624776

Doring, 1998, Leptin selectively increases energy expenditure of food-restricted lean mice, International Journal of Obesity and Related Metabolic Disorders, 22, 83, 10.1038/sj.ijo.0800547

Chao, 2011, Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity, Cell Metabolism, 13, 573, 10.1016/j.cmet.2011.02.019

Bi, 2012, Dorsomedial hypothalamic NPY and energy balance control, Neuropeptides, 46, 309, 10.1016/j.npep.2012.09.002

Lee, 2013, Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice, Journal of Neuroscience, 33, 15306, 10.1523/JNEUROSCI.0837-13.2013

Madden, 2012, Orexin modulates brown adipose tissue thermogenesis, Biomolecular Concepts, 3, 381, 10.1515/bmc-2011-0066

Tupone, 2011, An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis, Journal of Neuroscience, 31, 15944, 10.1523/JNEUROSCI.3909-11.2011

Yamanaka, 2003, Hypothalamic orexin neurons regulate arousal according to energy balance in mice, Neuron, 38, 701, 10.1016/S0896-6273(03)00331-3

Berglund, 2014, Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia, Nature Neuroscience, 17, 911, 10.1038/nn.3737

Kong, 2012, GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure, Cell, 151, 645, 10.1016/j.cell.2012.09.020

Hermann, 2006, Leptin and thyrotropin-releasing hormone: cooperative action in the hindbrain to activate brown adipose thermogenesis, Brain Research, 1117, 118, 10.1016/j.brainres.2006.08.018

Harris, 2006, Energy expenditure and body composition of chronically maintained decerebrate rats in the fed and fasted condition, Endocrinology, 147, 1365, 10.1210/en.2005-1156

Barnes, 2010, Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat, Brain Research, 1355, 70, 10.1016/j.brainres.2010.07.094

Rezai-Zadeh, 2013, Integration of sensory information via central thermoregulatory leptin targets, Physiology & Behavior, 121, 49, 10.1016/j.physbeh.2013.02.014

Bates, 2004, LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin, Diabetes, 53, 3067, 10.2337/diabetes.53.12.3067

Girardier, 1995, Thermogenesis associated with spontaneous activity: an important component of thermoregulatory needs in rats, Journal of Physiology, 488, 779, 10.1113/jphysiol.1995.sp021009

Nakamura, 2011, Central efferent pathways for cold-defensive and febrile shivering, Journal of Physiology, 589, 3641, 10.1113/jphysiol.2011.210047

Hunt, 2010, Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 298, R130, 10.1152/ajpregu.00574.2009

Babic, 2010, Innervation of skeletal muscle by leptin receptor-containing neurons, Brain Research, 1345, 146, 10.1016/j.brainres.2010.05.042

Bachman, 2002, betaAR signaling required for diet-induced thermogenesis and obesity resistance, Science, 297, 843, 10.1126/science.1073160

Lecoultre, 2011, The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms, Journal of Clinical Endocrinology and Metabolism, 96, E1512, 10.1210/jc.2011-1286