Left atrial strain evaluation to assess left ventricle diastolic dysfunction and heart failure with preserved ejection fraction: a guide to clinical practice

Mariana Silva1, Francisco Sampaio1, Joana Braga1, José Ribeiro1, Ricardo Fontes‐Carvalho2
1Cardiology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Espinho, Portugal
2Cardiovascular R&D Centre – UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

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Tan YT, Wenzelburger F, Lee E, Nightingale P, Heatlie G, Leyva F et al (2010) Reduced left atrial function on exercise in patients with heart failure and normal ejection fraction.Heart.

Van Riet EES, Hoes AW, Wagenaar KP, Limburg A, Landman MAJ, Rutten FH (2016) Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review.Eur. J. Heart Fail.

Seferović PM, Petrie MC, Filippatos GS, Anker SD, Rosano G, Bauersachs J et al (2018) Type 2 diabetes mellitus and heart failure: a position statement from the heart failure association of the European Society of Cardiology.Eur J Heart Fail.

Fontes-Carvalho R, Ladeiras-Lopes R, Bettencourt P, Leite-Moreira A, Azevedo A (2015) Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes. Cardiovasc Diabetol [Internet]. ;14:4. Available from: http://www.cardiab.com/content/14/1/4

Stienen S, Ferreira JP, Kobayashi M, Preud’homme G, Dobre D, Machu J-L et al (2020) Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure). Biomarkers [Internet]. ;25:201–11. Available from: https://www.tandfonline.com/doi/full/https://doi.org/10.1080/1354750X.2020.1727015

Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T et al (2016) Recommendations for the evaluation of left ventricular diastolic function by Echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.J Am Soc Echocardiogr.

Nagueh SF (2020) Left ventricular diastolic function: understanding pathophysiology, diagnosis, and Prognosis with Echocardiography. JACC Cardiovasc. Imaging

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M et al (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J [Internet]. ;42:3599–726. Available from: https://academic.oup.com/eurheartj/article/42/36/3599/6358045

Smiseth OA, Morris DA, Cardim N, Cikes M, Delgado V, Donal E et al (2022) Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging. Eur Hear J - Cardiovasc Imaging [Internet]. ;23:e34–61. Available from: https://academic.oup.com/ehjcimaging/article/23/2/e34/6419840

W.W.F (1958) Movement of the heart and blood in animals, an anatomical essay.Am Heart J.

Hitch DC, Nolan SP (1981) Descriptive analysis of instantaneous left atrial volume-with special reference to left atrial function.J Surg Res.

Mitchell JH, Gilmore JP, Sarnoff SJ (1962) The transport function of the atrium. Factors influencing the relation between mean left atrial pressure and left ventricular end diastolic pressure*.Am J Cardiol.

Suga H (1974) Importance of atrial compliance in cardiac performance.Circ Res.

Grant C, Bunnell IL, Greene DG (1964) The reservoir function of the left atrium during ventricular systole. An angiocardiographic study of atrial stroke volume and work.Am J Med.

BRAUNWALD E, FRAHM C. Studies on Starling’s Law of the heart: IV. Observations on the hemodynamic functions of the Left Atrium in Man.Circulation.

Pagel PS, Kehl F, Gare M, Hettrick DA, Kersten JR, Warltier DC (2003) Mechanical function of the left atrium: new insights based on analysis of pressure-volume relations and Doppler echocardiography.Anesthesiology.

Pozzoli M, Capomolla S, Sanarico M, Pinna G, Cobelli F, Tavazzi L (1995) Doppler evaluations of left ventricular diastolic filling and pulmonary wedge pressure provide similar prognostic information in patients with systolic dysfunction after myocardial infarction.Am Heart J.

Mitchell JH, Shapiro W (1969) Atrial function and the hemodynamic consequences of atrial fibrillation in man.Am J Cardiol.

Appleton CP, Hatle LK, Popp RL (1988) Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiographic study.J Am Coll Cardiol.

Hoit BD, Shao Y, Gabel M, Walsh RA (1994) In vivo assessment of left atrial contractile performance in normal and pathological conditions using a time-varying elastance model.Circulation.

Thomas L, Levett K, Boyd A, Leung DYC, Schiller NB, Ross DL (2002) Compensatory changes in atrial volumes with normal aging: is atrial enlargement inevitable?J Am Coll Cardiol.

Thomas L, Levett K, Boyd A, Leung DYC, Schiller NB, Ross DL (2003) Changes in regional left atrial function with aging: evaluation by doppler tissue imaging.Eur J Echocardiogr.

Toutouzas K, Trikas A, Pitsavos C, Barbetseas J, Androulakis A, Stefanadis C et al (1996) Echocardiographic features of left atrium in elite male athletes.Am J Cardiol.

Barbier P, Solomon SB, Schiller NB, Glantz SA (1999) Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function.Circulation.

Toma Y, Matsuda Y, Moritani K, Ogawa H, Matsuzaki M, Kusukawa R (1987) Left atrial filling in normal human subjects: relation between left atrial contraction and left atrial early filling.Cardiovasc Res.

Nappo R, Degiovanni A, Bolzani V, Sartori C, Di Giovine G, Cerini P et al (2016) Quantitative assessment of atrial conduit function: a new index of diastolic dysfunction.Clin Res Cardiol.

Manning WJ, Katz SE, Douglas PS, Silverman DI (1993) Atrial ejection force: a noninvasive assessment of atrial systolic function.J Am Coll Cardiol.

D’Hooge J, Heimdal A, Jamal F, Kukulski T, Bijnens B, Rademakers F et al (2000) Regional strain and strain rate measurements by Cardiac Ultrasound: principles, implementation and Limitations.Eur J Echocardiogr.

Mirsky I, Parmley WW (1973) Assessment of passive elastic stiffness for isolated heart muscle and the intact heart.Circ Res.

Reisner SA, Lysyansky P, Agmon Y, Mutlak D, Lessick J, Friedman Z (2004) Global longitudinal strain: a novel index of left ventricular systolic function.J Am Soc Echocardiogr.

Kim DG, Lee KJ, Lee S, Jeong SY, Lee YS, Choi YJ et al (2009) Feasibility of two-dimensional global longitudinal strain and strain rate imaging for the assessment of left atrial function: a study in subjects with a low probability of cardiovascular disease and normal exercise capacity.Echocardiography.

Cameli M, Lisi M, Righini FM, Mondillo S (2012) Novel echocardiographic techniques to assess left atrial size, anatomy and function.Cardiovasc. Ultrasound.

Cameli M, Caputo M, Mondillo S, Ballo P, Palmerini E, Lisi M et al (2009) Feasibility and reference values of left atrial longitudinal strain imaging by two-dimensional speckle tracking.Cardiovasc Ultrasound.

Pathan F, D’Elia N, Nolan MT, Marwick TH, Negishi K (2017) Normal ranges of left atrial strain by Speckle-Tracking Echocardiography: a systematic review and Meta-analysis.J Am Soc Echocardiogr.

Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T et al (2018) Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging.Eur Heart J Cardiovasc Imaging.

Smiseth OA, Baron T, Marino PN, Marwick TH, Flachskampf FA (2021) Imaging of the left atrium: pathophysiology insights and clinical utility. Eur Hear J - Cardiovasc Imaging [Internet]. ;23:2–13. Available from: https://academic.oup.com/ehjcimaging/article/23/1/2/6380641

Ladeiras-Lopes R, Araújo M, Sampaio F, Leite-Moreira A, Fontes-Carvalho R (2019) The impact of diastolic dysfunction as a predictor of cardiovascular events: a systematic review and meta-analysis.Rev Port Cardiol.

Fontes-Carvalho R, Leite-Moreira A (2011) Insuficiência cardíaca com fração de ejeção preservada: combater equívocos para uma nova abordagem. Arq Bras Cardiol [Internet]. ;96:504–14. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2011000600012&lng=pt&nrm=iso&tlng=pt

Redfield MM, Jacobsen SJ, Burnett JC, Mahoney DW, Bailey KR, Rodeheffer RJ (2003) Burden of systolic and diastolic ventricular dysfunction in the community.JAMA.

Wan SH, Vogel MW, Chen HH (2014) Pre-clinical diastolic dysfunction.J. Am. Coll. Cardiol.

Teo SG, Yang H, Chai P, Yeo TC (2010) Impact of left ventricular diastolic dysfunction on left atrial volume and function: a volumetric analysis.Eur J Echocardiogr.

Vieira MJ, Teixeira R, Gonçalves L, Gersh BJ (2014) Left atrial mechanics: echocardiographic assessment and clinical implications.J. Am. Soc. Echocardiogr.

Almeida JG, Fontes-Carvalho R, Sampaio F, Ribeiro J, Bettencourt P, Flachskampf FA et al (2018) Impact of the 2016 ASE/EACVI recommendations on the prevalence of diastolic dysfunction in the general population. Eur Heart J Cardiovasc Imaging 19:380–386

van de Bovenkamp AA, Enait V, de Man FS, Oosterveer FTP, Bogaard HJ, Vonk Noordegraaf A et al (2021) Validation of the 2016 ASE/EACVI Guideline for Diastolic Dysfunction in Patients With Unexplained Dyspnea and a Preserved Left Ventricular Ejection Fraction. J Am Heart Assoc [Internet]. ;10. Available from: https://www.ahajournals.org/doi/https://doi.org/10.1161/JAHA.121.021165

Saraiva RM, Demirkol S, Buakhamsri A, Greenberg N, Popović ZB, Thomas JD et al (2010) Left atrial strain measured by Two-Dimensional Speckle Tracking Represents a New Tool to evaluate left atrial function.J Am Soc Echocardiogr.

Singh A, Addetia K, Maffessanti F, Mor-Avi V, Lang RM (2017) LA strain for categorization of LV Diastolic Dysfunction.JACC Cardiovasc Imaging.

Khan UA, De Simone G, Hill J, Tighe DA, Aurigemma GP (2013) Depressed atrial function in diastolic dysfunction: a speckle tracking imaging study.Echocardiography.

Braunauer K, Pieske-Kraigher E, Belyavskiy E, Aravind-Kumar R, Kropf M, Kraft R et al (2018) Early detection of cardiac alterations by left atrial strain in patients with risk for cardiac abnormalities with preserved left ventricular systolic and diastolic function.Int J Cardiovasc Imaging.

Brecht A, Oertelt-Prigione S, Seeland U, Rücke M, Hättasch R, Wagelöhner T et al (2016) Left atrial function in preclinical diastolic dysfunction: Two-Dimensional Speckle-Tracking Echocardiography–Derived results from the BEFRI Trial.J Am Soc Echocardiogr.

Hewing B, Theres L, Spethmann S, Stangl K, Dreger H, Knebel F (2017) Left atrial strain predicts hemodynamic parameters in cardiovascular patients.Echocardiography.

Cameli M, Mandoli GE, Loiacono F, Dini FL, Henein M, Mondillo S (2016) Left atrial strain: a new parameter for assessment of left ventricular filling pressure.Heart Fail Rev.

Wakami K, Ohte N, Asada K, Fukuta H, Goto T, Mukai S et al (2009) Correlation between Left Ventricular End-diastolic pressure and peak left Atrial Wall strain during left ventricular systole.J Am Soc Echocardiogr.

Cameli M, Lisi M, Mondillo S, Padeletti M, Ballo P, Tsioulpas C et al (2010) Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure.Cardiovasc Ultrasound.

Morris DA, Belyavskiy E, Aravind-Kumar R, Kropf M, Frydas A, Braunauer K et al (2018) Potential usefulness and clinical relevance of adding left atrial strain to left atrial volume index in the detection of left ventricular diastolic dysfunction. JACC Cardiovasc Imaging

Inoue K, Khan FH, Remme EW, Ohte N, García-Izquierdo E, Chetrit M et al (2021) Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure. Eur Hear J - Cardiovasc Imaging [Internet]. ;23:61–70. Available from: https://academic.oup.com/ehjcimaging/article/23/1/61/6120376

Venkateshvaran A, Tureli HO, Faxén UL, Lund LH, Tossavainen E, Lindqvist P (2022) Left atrial reservoir strain improves diagnostic accuracy of the 2016 ASE/EACVI diastolic algorithm in patients with preserved left ventricular ejection fraction: insights from the KARUM haemodynamic database. Eur Hear J - Cardiovasc Imaging [Internet]. ;23:1157–68. Available from: https://academic.oup.com/ehjcimaging/article/23/9/1157/6532371

Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH et al (2007) Cardiovascular features of heart failure with preserved ejection Fraction Versus Nonfailing Hypertensive Left Ventricular Hypertrophy in the Urban Baltimore Community. The role of atrial Remodeling/Dysfunction.J Am Coll Cardiol.

Melenovsky V, Hwang SJ, Redfield MM, Zakeri R, Lin G, Borlaug BA (2015) Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction.Circ Hear Fail.

Santos ABS, Kraigher-Krainer E, Gupta DK, Claggett B, Zile MR, Pieske B et al (2014) Impaired left atrial function in heart failure with preserved ejection fraction.Eur J Heart Fail.

Freed BH, Daruwalla V, Cheng JY, Aguilar FG, Beussink L, Choi A et al (2016) Prognostic utility and clinical significance of Cardiac mechanics in Heart failure with preserved ejection fraction: importance of left atrial strain.Circ Cardiovasc Imaging.

Kurt M, Wang J, Torre-Amione G, Nagueh SF (2009) Left atrial function in diastolic heart failure.Circ Cardiovasc Imaging.

Santos ABS, Roca GQ, Claggett B, Sweitzer NK, Shah SJ, Anand IS et al (2016) Prognostic relevance of left atrial dysfunction in heart failure with preserved ejection fraction.Circ Hear Fail.

Liu S, Guan Z, Zheng X, Meng P, Wang Y, Li Y et al (2018) Impaired left atrial systolic function and inter-atrial dyssynchrony may contribute to symptoms of heart failure with preserved left ventricular ejection fraction: a comprehensive assessment by echocardiography.Int J Cardiol.

Thomas L, Marwick TH, Popescu BA, Donal E, Badano LP (2019) Left atrial structure and function, and left ventricular diastolic dysfunction: JACC state-of-the-art review.J. Am. Coll. Cardiol.

Voigt J, Badano L, Georgiana-grat M (2020) How to do LA strain. Eur Hear J - Cardiovasc Imaging 32:715–717

Nielsen AB, Skaarup KG, Hauser R, Johansen ND, Lassen MCH, Jensen GB et al (2021) Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography: the Copenhagen City Heart Study. Eur Hear J - Cardiovasc Imaging [Internet]. ;23:42–51. Available from: https://academic.oup.com/ehjcimaging/article/23/1/42/6386403

Boe E, Smiseth OA (2022) Left atrial strain imaging: ready for clinical implementation in heart failure with preserved ejection fraction. Eur Hear J - Cardiovasc Imaging [Internet]. ;23:1169–70. Available from: https://academic.oup.com/ehjcimaging/article/23/9/1169/6564093

Donal E, Lip GYH, Galderisi M, Goette A, Shah D, Marwan M et al (2016) EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation. Eur Hear J – Cardiovasc Imaging [Internet]. ;17:355–83. Available from: https://academic.oup.com/ehjcimaging/article-lookup/doi/https://doi.org/10.1093/ehjci/jev354

Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E et al (2019) How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J [Internet]. ;40:3297–317. Available from: https://academic.oup.com/eurheartj/article/40/40/3297/5557740

Cameli M, Sparla S, Losito M, Righini FM, Menci D, Lisi M et al (2016) Correlation of Left Atrial Strain and Doppler Measurements with Invasive Measurement of Left Ventricular End-Diastolic Pressure in Patients Stratified for Different Values of Ejection Fraction. Echocardiography.

Kurt M, Tanboga IH, Aksakal E, Kaya A, Isik T, Ekinci M et al (2012) Relation of left ventricular end-diastolic pressure and N-terminal pro-brain natriuretic peptide level with left atrial deformation parameters.Eur Heart J Cardiovasc Imaging.

Morris DA, Takeuchi M, Krisper M, Köhncke C, Bekfani T, Carstensen T et al (2015) Normal values and clinical relevance of left atrial myocardial function analysed by speckle-tracking echocardiography:multicentre study.Eur Heart J Cardiovasc Imaging.

Cameli M, Lisi M, Focardi M, Reccia R, Natali BM, Sparla S et al (2012) Left atrial deformation analysis by speckle tracking echocardiography for prediction of cardiovascular outcomes.Am J Cardiol.

Sanchis L, Gabrielli L, Andrea R, Falces C, Duchateau N, Perez-Villa F et al (2015) Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection fraction.Eur Heart J Cardiovasc Imaging.