LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes

American Journal of Physiology - Endocrinology and Metabolism - Tập 325 Số 3 - Trang E244-E251 - 2023
Sarah Byberg1, Martin Bæk Blond1,2, Stephanie Holm1,3, Hanan Amadid4, Lea Bruhn4, Kim Katrine Bjerring Clemmensen4, Kristine Færch1,2, Birgitte Holst1
1Department of Biomedical Sciences, Faculty of Health and Medical, Sciences, University of Copenhagen, Copenhagen, Denmark
2Department of Clinical Research, Copenhagen University Hospital – Steno Diabetes Center Copenhagen, Herlev, Denmark
3Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
4Department of Data Science, Novo Nordisk, Herlev, Denmark

Tóm tắt

LEAP2, primarily secreted by the liver, increases with greater body mass, insulin resistance, and liver-specific enzymes in individuals with prediabetes and overweight or obesity. Fasting glucose, body mass, and alanine aminotransferase independently predict LEAP2 levels. LEAP2 is inversely linked to impaired kidney function. Elevated LEAP2 levels might indicate an increased metabolic risk, warranting further investigation into its potential involvement in glucose and body weight control.

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Thông tin xuất bản

American Journal of Physiology - Endocrinology and Metabolism

Tập 325 Số 3

E244-E251

Thông tin tác giả