LDH (Lactate Dehydrogenase): A Biochemical Marker for the Prediction of Adverse Outcomes in Pre-eclampsia and Eclampsia

Craici I, Wagner S, Garovic VD. Pre-eclampsia and future cardiovascular risk: formal risk factor or failed stress test? Ther Adv Cardiovasc Dis. 2008;2(4):249–59.

Cunningham FC, Leveno KJ, Bloom SL, et al. Williams obstetrics. 23rd ed. New York: McGraw-Hill; 2010. p. 706.

Tsoi SCM, Zheng J, Xu F, et al. Differential expression of lactate dehydrogenase isozymes (LDH) in human placenta with high expression of LDH-A4 isozyme in the endothelial cells of pre-eclampsia villi. Placenta. 2001;22(317):22.

Kay HH, Zhu S, Tsoi S. Hypoxia and lactate production in trophoblast cells. Placenta. 2007;28(8-9):854–60.

Burd LI, Simmons MA, Makowski EL, et al. Placental production and foetal utilization of lactate and pyruvate. Nature. 1975;254:710–1.

Bougneres PF, Rocchiccioli F, Nurjhan N, et al. Stable isotope determination of plasma lactate conversion into glucose in fasting infants. Am J Physiol. 1995;268:E652–800.

Markert CL, Shaklee JB, Whitt GS. Evolution of a gene: multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation. Science. 1975;189:102–500.

Semenza GL, Roth PH, Fang HM, et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem. 1994;269:23757–63.

Hofmeyr GJ, Belfort M. Proteinuria as a predictor of complications of pre-eclampsia. BMC Med. 2009;7:11.

Tompkins MJ, Thiagarajah S. HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome: the benefit of corticosteroids. Am J Obstet Gynecol. 1999;181:304–9.

O’Brien JM, Milligan DA, Barton JR. Impact of high-dose corticosteroid therapy for patients with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome. Am J Obstet Gynecol. 2000;183(4):921–4.

O’Brien JM, Shumate SA, Satchwell SL, et al. Maternal benefit to corticosteroid therapy in patients with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome: impact on the rate of regional anesthesia. Am J Obstet Gynecol. 2002;186:475–9.

Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynaecol. 2004;103(5):1–981.

Ali BS, Ghafoorian J, Alizadeh Sm. Severe pre-eclampsia and eclampsia in Kerman, Iran, complications and outcomes. Med Sci Monit. 2004;10(4):CR163–7.

Demir SC, Evruke C, Ozgunen FT, et al. Factors that influences morbidity and mortality in severe pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome. Saudi Med J. 2006;27(7):1015–8.

Qublan HS, Ammarin V, Bataineh O. Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia. Med Sci Monit. 2005;11(8):CR393–7.

Liu D, Liu H, Zeng W. Clinical analysis of PIH with abnormal liver function in 66 patients. Hunan Yi Ke Da Xue Xue Bao. 1998;23(3):302–24.

Jaiswar SP, Gupta A, Sachan R, et al. Lactic dehydrogenase: a biochemical marker for preeclampsia–eclampsia. J Obstet Gynaecol India. 2011;61(6):645–8.

Kozic JR, Benton SJ, Hutcheon JA, et al. Abnormal liver function tests as predictors of adverse maternal outcomes in women with pre-eclampsia. J Obstet Gynaecol Can. 2011;33(10):995–1004.

Sonagra AD, Dattatreya K, Jayaprakash Murty DS. Serum LDH, ALP and uric acid in hypertensive disorders of pregnancy. Int J Pharm Bio Sci. 2012;2(3):201–9.