K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Immunity - Tập 38 Số 6 - Trang 1142-1153 - 2013
Raúl Muñoz-Planillo1, Peter Kuffa1, Giovanny J. Martínez-Colón1, Barbara L. Smith1, Thekkelnaycke M. Rajendiran1,2, Gabriel Núñez1
1Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

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Allam, 2011, Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome, J. Immunol., 186, 2714, 10.4049/jimmunol.1002657

Andersen, 2005, Gramicidin channels, IEEE Trans. Nanobioscience, 4, 10, 10.1109/TNB.2004.842470

Bauernfeind, 2009, Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, J. Immunol., 183, 787, 10.4049/jimmunol.0901363

Bauernfeind, 2011, Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome, J. Immunol., 187, 613, 10.4049/jimmunol.1100613

Blaustein, 1975, Membrane potentials in pinched-off presynaptic nerve ternimals monitored with a fluorescent probe: evidence that synaptosomes have potassium diffusion potentials, J. Physiol., 247, 589, 10.1113/jphysiol.1975.sp010949

Chen, 2012, Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages, J. Biol. Chem., 287, 18806, 10.1074/jbc.M112.340935

Chifflet, 2004, Effect of membrane potential depolarization on the organization of the actin cytoskeleton of eye epithelia. The role of adherens junctions, Exp. Eye Res., 79, 769, 10.1016/j.exer.2004.08.031

Compan, 2012, Cell volume regulation modulates NLRP3 inflammasome activation, Immunity, 37, 487, 10.1016/j.immuni.2012.06.013

Cruz, 2007, ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages, J. Biol. Chem., 282, 2871, 10.1074/jbc.M608083200

Decleva, 2006, Common methodology is inadequate for studies on the microbicidal activity of neutrophils, J. Leukoc. Biol., 79, 87, 10.1189/jlb.0605338

Fernandes-Alnemri, 2010, The AIM2 inflammasome is critical for innate immunity to Francisella tularensis, Nat. Immunol., 11, 385, 10.1038/ni.1859

Franchi, 2009, Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation, J. Immunol., 183, 792, 10.4049/jimmunol.0900173

Franchi, 2012, Sensing and reacting to microbes through the inflammasomes, Nat. Immunol., 13, 325, 10.1038/ni.2231

Guicciardi, 2004, Lysosomes in cell death, Oncogene, 23, 2881, 10.1038/sj.onc.1207512

Gurcel, 2006, Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival, Cell, 126, 1135, 10.1016/j.cell.2006.07.033

Hoffman, 2001, Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome, Nat. Genet., 29, 301, 10.1038/ng756

Hornung, 2008, Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Nat. Immunol., 9, 847, 10.1038/ni.1631

Jin, 2011, NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy, Proc. Natl. Acad. Sci. USA, 108, 14867, 10.1073/pnas.1111101108

Juliana, 2010, Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome, J. Biol. Chem., 285, 9792, 10.1074/jbc.M109.082305

Langheinrich, 1997, Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation, J. Physiol., 502, 397, 10.1111/j.1469-7793.1997.397bk.x

Lee, 2012, The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP, Nature, 492, 123, 10.1038/nature11588

Lopez-Castejon, 2010, P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases, J. Immunol., 185, 2611, 10.4049/jimmunol.1000436

Mariathasan, 2004, Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf, Nature, 430, 213, 10.1038/nature02664

Mariathasan, 2006, Cryopyrin activates the inflammasome in response to toxins and ATP, Nature, 440, 228, 10.1038/nature04515

Martinon, 2006, Gout-associated uric acid crystals activate the NALP3 inflammasome, Nature, 440, 237, 10.1038/nature04516

Meng, 2009, A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses, Immunity, 30, 860, 10.1016/j.immuni.2009.04.012

Pelegrin, 2006, Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor, EMBO J., 25, 5071, 10.1038/sj.emboj.7601378

Peppelenbosch, 1999, Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways, Blood, 93, 4011, 10.1182/blood.V93.11.4011

Perregaux, 1994, Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity, J. Biol. Chem., 269, 15195, 10.1016/S0021-9258(17)36591-2

Perregaux, 1998, Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations, Am. J. Physiol., 275, C1538, 10.1152/ajpcell.1998.275.6.C1538

Pétrilli, 2007, Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration, Cell Death Differ., 14, 1583, 10.1038/sj.cdd.4402195

Qu, 2011, Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation, J. Immunol., 186, 6553, 10.4049/jimmunol.1100478

Rose, 1997, Regulation of intracellular sodium in cultured rat hippocampal neurones, J. Physiol., 499, 573, 10.1113/jphysiol.1997.sp021951

Schroder, 2010, The inflammasomes, Cell, 140, 821, 10.1016/j.cell.2010.01.040

Shenoy, 2012, GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals, Science, 336, 481, 10.1126/science.1217141

Shimada, 2012, Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Immunity, 36, 401, 10.1016/j.immuni.2012.01.009

Steinberg, 1987, ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes, J. Biol. Chem., 262, 8884, 10.1016/S0021-9258(18)47497-2

Surprenant, 1996, The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7), Science, 272, 735, 10.1126/science.272.5262.735

Tschopp, 2010, NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?, Nat. Rev. Immunol., 10, 210, 10.1038/nri2725

Wen, 2012, A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?, Nat. Immunol., 13, 352, 10.1038/ni.2228

Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663