Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Cell Metabolism - Tập 24 Số 1 - Trang 158-166 - 2016
Vicky Lampropoulou1, Alexey Sergushichev2,1, Monika Bambousková1, Sharmila Nair3, Emma E. Vincent4,5, Ekaterina Loginicheva1, Luisa Cervantes‐Barragán1, Xiucui Ma6,7, Stanley Ching‐Cheng Huang1, Takla Griss4,5, Carla J. Weinheimer8,7, Shabaana A. Khader9, Gwendalyn J. Randolph1, Edward J. Pearce1,10, Russell G. Jones4,5, Abhinav Diwan6,7, Michael Diamond11,3,9,1, Maxim N. Artyomov11,1
1Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
2Computer Technologies Department, ITMO University, Saint Petersburg 197101, Russia
3Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
4Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada
5Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada
6Center for Cardiovascular Research in Department of Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
7John Cochran VA Medical Center, St. Louis, MO 63108, USA
8Division of Cardiology and Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA
9Department of Molecular Microbiology, Washington University at St. Louis, St. Louis, MO 63110, USA
10Faculty of Biology, University of Freiburg, and Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany
11Center for Human Immunology and Immunotherapy Programs, Washington University at St. Louis, St. Louis, MO 63110, USA

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