Oguogho1, Lupattelli2, Giancarlo Palumbo3, H. Sinzinger4
1Department of Nuclear Medicine, University of Vienna, Austria
2Department of Internal Medicine, University of Perugia
3Institute of Nuclear Medicine, University of Perugia, Italy
4Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Austria
Tóm tắt
Background: Isoprostanes and in particular 8-epi-PGF2alpha have been claimed as a useful measure for in-vivo oxidation injury. While smokers show elevated 8-epi-PGF2alpha, the behaviour during quitting smoking is unknown. Methods and results: We determined 8-epi-PGF2alpha in 7 healthy adults ready to quit smoking in plasma, serum and urine by means of an enzyme immunoassay after extraction and purification before quitting smoking and during a follow-up period of 4 weeks. After quitting smoking, 8-epi-PGF2alpha shows a rapid decline within a few days almost completely normalizing within 4 weeks. Conclusion: The cigarette-smoking associated in-vivo oxidation injury almost completely disappears within 4 weeks of quitting smoking.
