Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo?

Journal of Cereal Science - Tập 48 Số 2 - Trang 258-276 - 2008
Anthony Fardet1, Edmond Rock1, Lydie Combaret1
1Unité de Nutrition Humaine, INRA-UMR 1019, Centre de Recherche de Clermont-Ferrand/Theix, 63122 Saint-Genès-Champanelle, France

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Adom, 2002, Antioxidant activity of grains, Journal of Agricultural and Food Chemistry, 50, 6182, 10.1021/jf0205099

Adom, 2003, Phytochemical profiles and antioxidant activity of wheat varieties, Journal of Agricultural and Food Chemistry, 51, 7825, 10.1021/jf030404l

Alvarez, 2006, Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leucocytes, European Journal of Nutrition, 45, 428, 10.1007/s00394-006-0616-9

Anderson, 2003, Whole grains protect against atherosclerotic cardiovascular disease, The Proceedings of the Nutrition Society, 62, 135, 10.1079/PNS2002222

Andersson, 2007, Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects, Journal of Nutrition, 137, 1401, 10.1093/jn/137.6.1401

Andreasen, 2000, Content of phenolic acids and ferulic acid dehydrodimers in 17 rye (Secale cereale L.) varieties, Journal of Agricultural and Food Chemistry, 48, 2837, 10.1021/jf991266w

Andreasen, 2001, Antioxidant effects of phenolic rye (Secale cereale L.) extracts, monomeric hydroxycinnamates, and ferulic acid dehydrodimers on human low-density lipoproteins, Journal of Agricultural and Food Chemistry, 49, 4090, 10.1021/jf0101758

Anjaneyulu, 2004, Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats, Pharmacology, 72, 42, 10.1159/000078631

Aruoma, 1998, Free radicals, oxidative stress, and antioxidants in human health and disease, Journal of the American Oil Chemists Society, 75, 199, 10.1007/s11746-998-0032-9

Awika, 2003, Screening methods to measure antioxidant activity of sorghum (Sorghum bicolor) and sorghum products, Journal of Agricultural and Food Chemistry, 51, 6657, 10.1021/jf034790i

Awika, 2005, Anthocyanins from black sorghum and their antioxidant properties, Food Chemistry, 90, 293, 10.1016/j.foodchem.2004.03.058

Bansal, 2005, Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver, Chemico-Biological Interactions, 156, 101, 10.1016/j.cbi.2005.08.001

Barak, 2003, Betaine lowers elevated S-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats, Journal of Nutrition, 133, 2845, 10.1093/jn/133.9.2845

Battelli, 1972, Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat, Biochemical Journal, 126, 747, 10.1042/bj1260747

Baublis, 2000, Potential of wheat-based breakfast cereals as a source of dietary antioxidants, Journal of the American College of Nutrition, 19, 308S, 10.1080/07315724.2000.10718965

Begum, 2004, Dietary lignins are precursors of mammalian lignans in rats, Journal of Nutrition, 134, 120, 10.1093/jn/134.1.120

Braaten, 1994, Oat beta-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects, European Journal of Clinical Nutrition, 48, 465

Briviba, 2004, Supplementation of a diet low in carotenoids with tomato or carrot juice does not affect lipid peroxidation in plasma and feces of healthy men, Journal of Nutrition, 134, 1081, 10.1093/jn/134.5.1081

Bruce, 2000, A diet high in whole and unrefined foods favorably alters lipids, antioxidant defenses, and colon function, Journal of the American College of Nutrition, 19, 61, 10.1080/07315724.2000.10718915

Cao, 1998, Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables, American Journal of Clinical Nutrion, 68, 1081, 10.1093/ajcn/68.5.1081

Casiraghi, 2006, Post-prandial responses to cereal products enriched with barley beta-glucan, Journal of the American College of Nutrition, 25, 313, 10.1080/07315724.2006.10719541

Castelluccio, 1996, Differential distribution of ferulic acid to the major plasma constituents in relation to its potential as an antioxidant, Biochemical Journal, 316, 691, 10.1042/bj3160691

Chatenoud, 1999, Refined-cereal intake and risk of selected cancers in italy, American Journal of Clinical Nutrion, 70, 1107, 10.1093/ajcn/70.6.1107

Chatenoud, 1998, Whole grain food intake and cancer risk, International Journal of Cancer, 77, 24, 10.1002/(SICI)1097-0215(19980703)77:1<24::AID-IJC5>3.0.CO;2-1

Chen, 2004, Avenanthramides and phenolic acids from oats are bioavailable and act synergistically with vitamin C to enhance hamster and human LDL resistance to oxidation, Journal of Nutrition, 134, 1459, 10.1093/jn/134.6.1459

Chen, 2007, Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oats, Journal of Nutrition, 137, 1375, 10.1093/jn/137.6.1375

Chiang, 2006, Antioxidant effects of black rice extract through the induction of superoxide dismutase and catalase activities, Lipids, 41, 797, 10.1007/s11745-006-5033-6

Choi, 2007, Antioxidant activity of methanolic extracts from some grains consumed in Korea, Food Chemistry, 103, 130, 10.1016/j.foodchem.2006.08.004

Ciappellano, 1989, Effects of durum wheat dietary selenium on glutathione peroxidase activity and Se content in long-term-fed rats, Annals of Nutrition & Metabolism, 33, 22, 10.1159/000177517

Curtin, 2006, Selenium concentration in wheat (Triticum aestivum) grain as influenced by method, rate, and timing of sodium selenate application, New Zealand Journal of Crop and Horticultural Science, 34, 329, 10.1080/01140671.2006.9514423

de Oliveira, 2007, Processed and prepared corn products as sources of lutein and zeaxanthin: Compositional variation in the food chain, Journal of Food Science, 72, 10.1111/j.1750-3841.2006.00235.x

Del Pozo-Insfran, 2006, Polyphenolic and antioxidant content of white and blue corn (Zea mays L.) products, Food Research International, 39, 696, 10.1016/j.foodres.2006.01.014

Dewanto, 2002, Processed sweet corn has higher antioxidant activity, Journal of Agriculture and Food Chemistry, 50, 4959, 10.1021/jf0255937

Dykes, 2006, Sorghum and millet phenols and antioxidants, Journal of Cereal Science, 44, 236, 10.1016/j.jcs.2006.06.007

Eastwood, 1999, Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease?, QJM—an International Journal of Medicine, 92, 527, 10.1093/qjmed/92.9.527

Emmons, 1999, Antioxidant activity and phenolic contents of oat groats and hulls, Cereal Chemistry, 76, 902, 10.1094/CCHEM.1999.76.6.902

Emmons, 1999, Antioxidant capacity of oat (Avena sativa L.) extracts. 2. In vitro antioxidant activity and contents of phenolic and tocol antioxidants, Journal of Agricultural and Food Chemistry, 47, 4894, 10.1021/jf990530i

Esmaillzadeh, 2005, Whole-grain consumption and the metabolic syndrome: a favorable association in Tehranian adults, European Journal of Clinical Nutrition, 59, 353, 10.1038/sj.ejcn.1602080

Fardet, 2007, Whole grain and refined wheat flours show distinct metabolic profiles in rats as assessed by a 1H NMR-based metabonomic approach, Journal of Nutrition, 4, 923, 10.1093/jn/137.4.923

Feillet, 2000, Le grain de blé

Furukawa, 2004, Increased oxidative stress in obesity and its impact on metabolic syndrome, Journal of Clinical Investigation, 114, 1752, 10.1172/JCI21625

Gallardo, 2006, Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions, Food Chemistry, 99, 455, 10.1016/j.foodchem.2005.07.053

Goffman, 2004, Rice kernel phenolic content and its relationship with antiradical efficiency, Journal of the Science of Food and Agriculture, 84, 1235, 10.1002/jsfa.1780

Golestani, 2006, Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat, Clinica Chimica Acta, 365, 153, 10.1016/j.cca.2005.08.008

Graf, 1990, Antioxidant functions of phytic acid, Free Radical Biology & Medicine, 8, 61, 10.1016/0891-5849(90)90146-A

Graf, 1987, Phytic acid. A natural antioxidant, Journal of Biological Chemistry, 262, 11647, 10.1016/S0021-9258(18)60858-0

Gray, 2002, Antioxidant activity of oat extracts added to human LDL particles and in free radical trapping assays, Journal of Cereal Science, 36, 209, 10.1006/jcrs.2001.0456

Guo, 2007, Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats, Plant Foods for Human Nutrition, 62, 1, 10.1007/s11130-006-0031-7

Halliwell, 1991, DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems, FEBS Letters, 281, 9, 10.1016/0014-5793(91)80347-6

Halliwell, 2000, The gastrointestinal tract: a major site of antioxidant action?, Free Radical Research, 33, 819, 10.1080/10715760000301341

Hallund, 2006, A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women, Journal of Nutrition, 136, 112, 10.1093/jn/136.1.112

Handelman, 1999, Antioxidant capacity of oat (Avena sativa L.) extracts. 1. Inhibition of low-density lipoprotein oxidation and oxygen radical absorbance capacity, Journal of Agricultural and Food Chemistry, 47, 4888, 10.1021/jf990529j

Harder, 2004, Rye bran bread intake elevates urinary excretion of ferulic acid in humans, but does not affect the susceptibility of LDL to oxidation ex vivo, European Journal of Nutrition, 43, 230, 10.1007/s00394-004-0463-5

Hegde, 2005, Effects of the antioxidant properties of millet species on oxidative stress and glycemic status in alloxan-induced rats, Nutrition Research, 25, 1109, 10.1016/j.nutres.2005.09.020

Hemery, 2007, Dry processes to develop wheat fractions and products with enhanced nutritional quality, Journal of Cereal Science, 46, 327, 10.1016/j.jcs.2007.09.008

Hernanz, 2001, Hydroxycinnamic acids and ferulic acid dehydrodimers in barley and processed barley, Journal of Agricultural and Food Chemistry, 49, 4884, 10.1021/jf010530u

Hosny, 1997, Structures of ferulic acid glycoside esters in corn hulls, Journal of Natural Products, 60, 219, 10.1021/np9605908

Hsieh, 2005, Alleviation of oxidative damage in multiple tissues in rats with streptozotocin-induced diabetes by rice bran oil supplementation, 365

Hu, 2003, Black rice (Oryza sativa L. indica) pigmented fraction suppresses both reactive oxygen species and nitric oxide in chemical and biological model systems, Journal of Agricultural and Food Chemistry, 51, 5271, 10.1021/jf034466n

Hung, 2004, Fruit and vegetable intake and risk of major chronic disease, Journal of the National Cancer Institute, 96, 1577, 10.1093/jnci/djh296

Hwang, 2007, Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research, Toxicology, 229, 1, 10.1016/j.tox.2006.10.013

Jang, 2001, Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial, Arteriosclerosis, Thrombosis, and Vascular Biology, 21, 2065, 10.1161/hq1201.100258

Juliano, 2005, Antioxidant activity of gamma-oryzanol: Mechanism of action and its effect on oxidative stability of pharmaceutical oils, International Journal of Pharmaceutics, 299, 146, 10.1016/j.ijpharm.2005.05.018

Kahlon, 1993, Cholesterol-lowering effects in hamsters of beta-glucan-enriched barley fraction, dehulled whole barley, rice bran, and oat bran and their combinations, Cereal Chemistry, 70, 435

Kamal-Eldin, 2001, Alkylresorcinols as antioxidants: hydrogen donation and peroxyl radical-scavenging effects, Journal of the Science of Food and Agriculture, 81, 353, 10.1002/1097-0010(200102)81:3<353::AID-JSFA826>3.0.CO;2-X

Kamath, 2004, Antiradical properties of sorghum (Sorghum bicolor L. Moench) flour extracts, Journal of Cereal Science, 40, 283, 10.1016/j.jcs.2004.08.004

Kern, 2003, Absorption of hydroxycinnamates in humans after high-bran cereal consumption, Journal of Agricultural and Food Chemistry, 51, 6050, 10.1021/jf0302299

Kim, 2006, The effects of a mixture of brown and black rice on lipid profiles and antioxidant status in rats, Annals of Nutrition and Metabolism, 50, 347, 10.1159/000094298

Kitts, 1999, Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone, Molecular and Cellular Biochemistry, 202, 91, 10.1023/A:1007022329660

Konopka, 2004, Lipids and carotenoids of wheat grain and flour and attempt of correlating them with digital image analysis of kernel surface and cross-sections, Food Research International, 37, 429, 10.1016/j.foodres.2003.12.009

Kozubek, 1995, Cereal grain resorcinolic lipids inhibit H2O2-induced peroxidation of biological membranes, Acta Biochimica Polonica, 42, 309, 10.18388/abp.1995_4589

Krawinkel, 2007, What we know and don't know about Golden Rice, Nature Biotechnology, 25, 10.1038/nbt0607-623

Labaj, 2004, Lignin-stimulated reduction of oxidative DNA lesions in testicular cells and lymphocytes of Sprague-Dawley rats in vitro and ex vivo, Nutrition and Cancer—an International Journal, 50, 198, 10.1207/s15327914nc5002_10

Laight, 1999, F-2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: effects of vitamin E, European Journal of Pharmacology, 377, 89, 10.1016/S0014-2999(99)00407-0

Lee, 2003, Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis, Journal of Biological Chemistry, 278, 12029, 10.1074/jbc.M211558200

Leenhardt, 2005, Moderate decrease of pH by sourdough fermentation is sufficient to reduce phytate content of whole wheat flour through endogenous phytase activity, Journal of Agricultural and Food Chemistry, 53, 98, 10.1021/jf049193q

Leenhardt, 2006, Genetic variability of carotenoid concentration, and lipoxygenase and peroxidase activities among cultivated wheat species and bread wheat varieties, European Journal of Agronomy, 25, 170, 10.1016/j.eja.2006.04.010

Leenhardt, F., Fardet, A., Lyan, B., Gueux, E., Rock, E., Mazur, A., Chanliaud, E., Demigné, C., Rémésy, C., in press. Wheat germ supplementation of a low vitamin E diet in rats affords a more effective antioxidant protection in tissues than in plasma. Journal of the American College of Nutrition.

Leonard, 2004, Vitamin E bioavailability from fortified breakfast cereal is greater than that from encapsulated supplements, American Journal of Clinical Nutrition, 79, 86, 10.1093/ajcn/79.1.86

Lewis, 1996, Lack of influence of intestinal transit on oxidative status in premenopausal women, European Journal of Clinical Nutrition, 50, 565

Li, 2004, Glutathione and related thiol compounds. I. Glutathione and related thiol compounds in flour, Journal of Cereal Science, 39, 205, 10.1016/j.jcs.2003.10.003

Li, 2007, High-amylose corn exhibits better antioxidant activity than typical and waxy genotypes, Journal of Agricultural and Food Chemistry, 55, 291, 10.1021/jf0622432

Ling, 2001, Red and black rice decrease atherosclerotic plaque formation and increase antioxidant status in rabbits, Journal of Nutrition, 131, 1421, 10.1093/jn/131.5.1421

Ling, 2002, Supplementation of the black rice outer layer fraction to rabbits decreases atherosclerotic plaque formation and increases antioxidant status, Journal of Nutrition, 132, 20, 10.1093/jn/132.1.20

Liu, 2007, Whole grain phytochemicals and health, Journal of Cereal Science, 46, 207, 10.1016/j.jcs.2007.06.010

Liu, 2007, Antioxidant activities of barley seeds extracts, Food Chemistry, 102, 732, 10.1016/j.foodchem.2006.06.051

Liyana-Pathirana, 2005, Antioxidant activity of commercial soft and hard wheat (Triticum aestivium L.) as affected by gastric pH conditions, Journal of Agricultural and Food Chemistry, 53, 2433, 10.1021/jf049320i

Liyana-Pathirana, 2006, Antioxidant properties of commercial soft and hard winter wheats (Triticum aestivum L.) and their milling fractions, Journal of the Science of Food and Agriculture, 86, 477, 10.1002/jsfa.2374

Liyana-Pathirana, 2006, Importance of insoluble-bound phenolics to antioxidant properties of wheat, Journal of Agricultural and Food Chemistry, 54, 1256, 10.1021/jf052556h

Liyana-Pathirana, 2007, The antioxidant potential of milling fractions from breadwheat and durum, Journal of Cereal Science, 45, 238, 10.1016/j.jcs.2006.08.007

Lopez, 2003, Making bread with sourdough improves mineral bioavailability from reconstituted whole wheat flour in rats, Nutrition, 19, 524, 10.1016/S0899-9007(02)01079-1

Lotito, 2004, The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids, Free Radical Biology & Medicine, 37, 251, 10.1016/j.freeradbiomed.2004.04.019

Lotito, 2004, Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects, Free Radical Biology & Medicine, 36, 201

Maillard, 1996, Antioxidant activity of barley and malt: Relationship with phenolic content, Food Science and Technology—Lebensmittel-Wissenschaft & Technologie, 29, 238, 10.1006/fstl.1996.0035

Mariotti, 2004, Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content, Journal of Nutrition, 134, 128, 10.1093/jn/134.1.128

Martin, 1996, Effect of vitamin E on human aortic endothelial cell responses to oxidative injury, Free Radical Biology and Medicine, 21, 505, 10.1016/0891-5849(96)00118-9

Martinez-Tome, 2004, Evaluation of antioxidant capacity of cereal brans, Journal of Agricultural and Food Chemistry, 52, 4690, 10.1021/jf049621s

Michalska, 2007, Antioxidant contents and antioxidative properties of traditional rye breads, Journal of Agricultural and Food Chemistry, 55, 734, 10.1021/jf062425w

Miller, 2000, Antioxidant content of whole grain breakfast cereals, fruits and vegetables, Journal of the American College of Nutrition, 19, 312S, 10.1080/07315724.2000.10718966

Minhajuddin, 2005, Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats, Food and Chemical Toxicology, 43, 747, 10.1016/j.fct.2005.01.015

Mitchell, 1996, Bioavailability for rats of vitamin E from fortified breakfast cereals, Journal of Food Science, 61, 1257, 10.1111/j.1365-2621.1996.tb10974.x

Moore, 2005, Carotenoid, tocopherol, phenolic acid, and antioxidant properties of Maryland-grown soft wheat, Journal of Agricultural and Food Chemistry, 53, 6649, 10.1021/jf050481b

Moore, 2006, Effects of genotype and environment on the antioxidant properties of hard winter wheat bran, Journal of Agricultural and Food Chemistry, 54, 5313, 10.1021/jf060381l

Morand, 1997, Influence of methionine availability on glutathione synthesis and delivery by the liver, The Journal of Nutritional Biochemistry, 8, 246, 10.1016/S0955-2863(97)89661-1

Muraoka, 2004, Inhibition of xanthine oxidase by phytic acid and its antioxidative action, Life Sciences, 74, 1691, 10.1016/j.lfs.2003.09.040

Myhrstad, 2002, Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter, Free Radical Biology and Medicine, 32, 386, 10.1016/S0891-5849(01)00812-7

Na, 2006, Intracellular signaling network as a prime chemopreventive target of (−)-epigallocatechin gallate, Molecular Nutrition and Food Research, 50, 152, 10.1002/mnfr.200500154

Nagah, 2005, In vitro procedure to predict apparent antioxidant release from wholegrain foods measured using three different analytical methods, Journal of the Science of Food and Agriculture, 85, 1177, 10.1002/jsfa.2106

Nilsson, 1997, Content of nutrients and lignans in roller milled fractions of rye, Journal of the Science of Food and Agriculture, 73, 143, 10.1002/(SICI)1097-0010(199702)73:2<143::AID-JSFA698>3.0.CO;2-H

Oki, 2002, Polymeric procyanidins as radical-scavenging components in red-hulled rice, Journal of Agricultural and Food Chemistry, 50, 7524, 10.1021/jf025841z

Olmo, 2007, In vitro models for the study of the effect of butyrate on human colon adenocarcinoma cells, Toxicology in Vitro, 21, 262, 10.1016/j.tiv.2006.09.011

Panfili, 2004, Improved normal-phase high-performance liquid chromatography procedure for the determination of carotenoids in cereals, Public Health Nutrition, 52, 6373

Parikka, 2006, In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols, Journal of Agricultural and Food Chemistry, 54, 1646, 10.1021/jf052486e

Parrado, 2003, Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran, European Journal of Nutrition, 42, 307, 10.1007/s00394-003-0424-4

Paterson, 2006, Supplementation with fruit and vegetable soups and beverages increases plasma carotenoid concentrations but does not alter markers of oxidative stress or cardiovascular risk factors, Journal of Nutrition, 136, 2849, 10.1093/jn/136.11.2849

Pellegrini, 2006, Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays, Molecular Nutrition & Food Research, 50, 1030, 10.1002/mnfr.200600067

Perez-Jimenez, 2005, Literature data may underestimate the actual antioxidant capacity of cereals, Journal of Agricultural and Food Chemistry, 53, 5036, 10.1021/jf050049u

Peterson, 2001, Oat antioxidants, Journal of Cereal Science, 33, 115, 10.1006/jcrs.2000.0349

Peterson, 2002, Oat avenanthramides exhibit antioxidant activities in vitro, Food Chemistry, 79, 473, 10.1016/S0308-8146(02)00219-4

Pool-Zobel, 2000, Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells, Carcinogenesis, 21, 1247, 10.1093/carcin/21.6.1247

Prior, 2003, Fruits and vegetables in the prevention of cellular oxidative damage, American Journal of Clinical Nutrition, 78, 570S, 10.1093/ajcn/78.3.570S

Ragaee, 2006, Antioxidant activity and nutrient composition of selected cereals for food use, Food Chemistry, 98, 32, 10.1016/j.foodchem.2005.04.039

Reeves, 2007, Determination of selenium bioavailability from wheat mill fractions in rats by using the slope-ratio assay and a modified Torula yeast-based diet, Journal of Agricultural and Food Chemistry, 55, 516, 10.1021/jf062572u

Reinosa, 1998, Yield and antioxidant activity of lignin obtained at different pH values, Boletin De La Sociedad Chilena De Quimica, 43, 367

Rezar, 2003, Wheat bran and oat bran effectively reduce oxidative stress induced by high-fat diets in pigs, Annals of Nutrition & Metabolism, 47, 78, 10.1159/000069279

Rezzi, 2007, Nutritional metabonomics: Applications and perspectives, Journal of Proteome Research, 6, 513, 10.1021/pr060522z

Rice-Evans, 1997, Antioxidant properties of phenolic compounds, Trends in Plant Science, 2, 152, 10.1016/S1360-1385(97)01018-2

Rimbach, 1998, Phytic acid inhibits free radical formation in vitro but does not affect liver oxidant or antioxidant status in growing rats, Journal of Nutrition, 128, 1950, 10.1093/jn/128.11.1950

Ross, 2003, Absorption of dietary alkylresorcinols in ileal-cannulated pigs and rats, British Journal of Nutrition, 90, 787, 10.1079/BJN2003965

Ross, 2003, Alkylresorcinols in cereals and cereal products, Journal of Agricultural and Food Chemistry, 51, 4111, 10.1021/jf0340456

Saura-Calixto, 2006, Antioxidant capacity of the Spanish Mediterranean diet, Food Chemistry, 94, 442, 10.1016/j.foodchem.2004.11.033

Saura-Calixto, 2007, Intake and bioaccessibility of total polyphenols in a whole diet, Food Chemistry, 101, 492, 10.1016/j.foodchem.2006.02.006

Scalbert, 2000, Dietary intake and bioavailability of polyphenols, Journal of Nutrition, 130, 2073S, 10.1093/jn/130.8.2073S

Schofield, 1995, Analysis of free reduced and free oxidized glutathione in wheat-flour, Journal of Cereal Science, 21, 127, 10.1016/0733-5210(95)90028-4

Serpen, 2007, A new procedure to measure the antioxidant activity of insoluble food components, Journal of Agricultural and Food Chemistry, 55, 7676, 10.1021/jf071291z

Shewry, 2007, Improving the protein content and composition of cereal grain, Journal of Cereal Science, 46, 239, 10.1016/j.jcs.2007.06.006

Skibsted, 2006, Antioxidants and health, Ugeskr Laeger, 168, 2787

Slamenova, 1999, Detection of lignin biopolymer- and vitamin E-stimulated reduction of DNA strand breaks in H2O2- and MNNG-treated mammalian cells by the comet assay, Nutrition and Cancer, 33, 88, 10.1080/01635589909514753

Slamenova, 2000, Oxidative/antioxidative effects of different lignin preparations on DNA in hamster V79 cells, Neoplasma, 47, 349

Slavin, 2003, Why whole grains are protective: biological mechanisms, Proceedings of the Nutrition Society, 62, 129, 10.1079/PNS2002221

Slavin, 1999, Plausible mechanisms for the protectiveness of whole grains, American Journal of Clinical Nutrition, 70, 459S, 10.1093/ajcn/70.3.459s

Sosulski, 1982, Free, esterified, and insoluble-bound phenolic acids. 3. Composition of phenolic acids in cereal and potato flours, Journal of Agricultural and Food Chemistry, 30, 337, 10.1021/jf00110a030

Souci, 2000

Subba Rao, 2002, Evaluation of the antioxidant properties of free and bound phenolic acids from native and malted finger millet (ragi, Eleusine coracana Indaf-15), Journal of Agricultural and Food Chemistry, 50, 889, 10.1021/jf011210d

Suh, 2005, Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats, Journal of Agricultural and Food Chemistry, 53, 9747, 10.1021/jf051912t

Thompson, 1994, Antioxidants and hormone-mediated health benefits of whole grains, Critical Reviews in Food Science and Nutrition, 34, 473, 10.1080/10408399409527676

Thompson, 2005, 8-Isoprostane F-2 alpha excretion is reduced in women by increased vegetable and fruit intake, American Journal of Clinical Nutrition, 82, 768, 10.1093/ajcn/82.4.768

Toyokuni, 2002, Protective effect of colored rice over white rice on Fenton reaction-based renal lipid peroxidation in rats, Free Radical Research, 36, 583, 10.1080/10715760290025960

Truswell, 2002, Cereal grains and coronary heart disease, European Journal of Clinical Nutrition, 56, 1, 10.1038/sj.ejcn.1601283

U.S. Department of Agriculture, A.R.S

Venn, 2004, Cereal grains, legumes and diabetes, European Journal of Clinical Nutrition, 58, 1443, 10.1038/sj.ejcn.1601995

Wang, 2007, Supplementation of black rice pigment fraction improves antioxidant and anti-inflammatory status in patients with coronary heart disease, Asia Pacific Journal of Clinical Nutrition, 16, 295

Ward, 1997, Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid, QJM—Monthly Journal of the Association of Physicians, 90, 519, 10.1093/qjmed/90.8.519

Wattenberg, 1996, Chemoprevention of cancer, Preventive Medicine, 25, 44, 10.1006/pmed.1996.0015

Winata, 1997, Effects of fermentation and baking of whole wheat and whole rye sourdough breads on cereal alkylresorcinols, Cereal Chemistry, 74, 284, 10.1094/CCHEM.1997.74.3.284

Wu, 2004, Lipophilic and hydrophilic antioxidant capacities of common foods in the United States, Journal of Agricultural and Food Chemistry, 52, 4026, 10.1021/jf049696w

Wu, 2004, Development of a database for total antioxidant capacity in foods: a preliminary study, Journal of Food Composition and Analysis, 17, 407, 10.1016/j.jfca.2004.03.001

Xia, 2003, Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice, Journal of Nutrition, 133, 744, 10.1093/jn/133.3.744

Xia, 2006, An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein e-deficient mice, Journal of Nutrition, 136, 2220, 10.1093/jn/136.8.2220

Xu, 2001, Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2′-azobis(2-methylpropionamidine) dihydrochloride, Journal of Agricultural and Food Chemistry, 49, 2077, 10.1021/jf0012852

Yu, 2004, Antioxidant properties of bran extracts from ‘Platte’ wheat grown at different locations, Food Chemistry, 90, 311, 10.1016/j.foodchem.2004.04.007

Yu, 2002, Antioxidant properties of hard winter wheat extracts, Food Chemistry, 78, 457, 10.1016/S0308-8146(02)00156-5

Yu, 2002, Free radical scavenging properties of wheat extracts, Journal of Agricultural and Food Chemistry, 50, 1619, 10.1021/jf010964p

Yu, 2003, Antioxidant properties of bran extracts from “Akron” wheat grown at different locations, Journal of Agricultural and Food Chemistry, 51, 1566, 10.1021/jf020950z

Yu, 2005, Inhibitory effects of wheat bran extracts on human LDL oxidation and free radicals, Food Science and Technology-Lebensmittel-Wissenschaft & Technologie, 38, 463, 10.1016/j.lwt.2004.07.005

Yuan, 1999, Short-term feeding of flaxseed or its lignan has minor influence on in vivo hepatic antioxidant status in young rats, Nutrition Research, 19, 1233, 10.1016/S0271-5317(99)00084-6

Zdunczyk, 2006, In vitro antioxidant activities of barley, husked oat, naked oat, triticale, and buckwheat wastes and their influence on the growth and biomarkers of antioxidant status in rats, Journal of Agricultural and Food Chemistry, 54, 4168, 10.1021/jf060224m

Zeisel, 2003, Concentrations of choline-containing compounds and betaine in common foods, Journal of Nutrition, 133, 1302, 10.1093/jn/133.5.1302

Zeisel, 2003, Content of choline-containing compounds and betaine in common foods, FASEB Journal, 17

Zhao, 2005, Phenolic antioxidants richly contained in corn bran are slightly bioavailable in rats, Journal of Agricultural and Food Chemistry, 53, 5030, 10.1021/jf050111n

Zhao, 2006, Effects of extraction solvent mixtures on antioxidant activity evaluation and their extraction capacity and selectivity for free phenolic compounds in barley (Hordeum vulgare L.), Journal of Agricultural and Food Chemistry, 54, 7277, 10.1021/jf061087w

Zhao, 2007, Selenium concentrations in UK wheat and biofortification strategies, Comparative Biochemistry and Physiology a—Molecular & Integrative Physiology, 146, 10.1016/j.cbpa.2007.01.571

Zhou, 1995, Phytic acid in health and disease, Critical Reviews in Food Science and Nutrition, 35, 495, 10.1080/10408399509527712

Zhou, 2004, Antioxidant properties of bran extracts from Trego wheat grown at different locations, Journal of Agricultural and Food Chemistry, 52, 1112, 10.1021/jf030621m

Zhou, 2004, Comparison of Swiss red wheat grain and fractions for their antioxidant properties, Journal of Agricultural and Food Chemistry, 52, 1118, 10.1021/jf030640w

Zhou, 2005, Phenolic acid, tocopherol and carotenoid compositions, and antioxidant functions of hard red winter wheat bran, Journal of Agricultural and Food Chemistry, 53, 3916, 10.1021/jf050117c

Zielinski, 2000, Antioxidant activity and total phenolics in selected cereal grains and their different morphological fractions, Journal of Agricultural and Food Chemistry, 48, 2008, 10.1021/jf990619o