Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?

European Journal of Nuclear Medicine - Tập 30 - Trang 325-328 - 2002
Ingeborg Goethals1, Christophe Van de Wiele1, Paul Boon2, Rudi Dierckx1
1Division of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, Ghent, Belgium
2Department of Neurology, Ghent University Hospital, Ghent, Belgium

Tóm tắt

In the presurgical evaluation of patients with partial epilepsies, the most extensively studied functional neuro-imaging modality to define the origin of seizure onset is fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET). Generally, this technique reveals a widespread zone of interictal glucose hypometabolism in the region of the epileptogenic focus. However, the technique may miss the epileptogenic region and FDG PET abnormalities may extend beyond the seizure onset zone. Consequently, for the precise identification of epileptogenic regions more specific imaging probes than FDG are warranted. This review considers the clinical utility of iomazenil (IMZ) SPET and flumazenil (FMZ) PET for the precise localization of epileptogenic foci in partial epilepsy syndromes.

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European Journal of Nuclear Medicine

Tập 30

325-328

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