Intramedullary Spinal Cord Tumors: Part I—Epidemiology, Pathophysiology, and Diagnosis

Global Spine Journal - Tập 5 Số 5 - Trang 425-435 - 2015
Dino Samartzis1,2, Chris Gillis3, Patrick Shih4, John E. O’Toole3, Richard G. Fessler3
1Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
2The Laboratory and Clinical Research Institute for Pain, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China
3Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, United States
4The Neurological Brain and Spine Center, Houston, Texas, United States

Tóm tắt

Study DesignBroad narrative review.ObjectivesIntramedullary spinal cord tumors (IMSCT) are rare neoplasms that can potentially lead to severe neurologic deterioration, decreased function, poor quality of life, or death. As such, a better understanding of these lesions is needed. The following article, part one of a two-part series, addresses IMSCT with regards to their epidemiology, histology, pathophysiology, imaging characteristics, and clinical manifestations.MethodsThe authors performed an extensive review of the peer-reviewed literature addressing the aforementioned objectives.ResultsNumerous IMSCT exist with varying epidemiology. Each IMSCT has its own hallmark characteristics and may vary with regards to how aggressively they invade the spinal cord. These lesions are often difficult to detect and are often misdiagnosed. Furthermore, radiographically and clinically, these lesions may be difficult to distinguish from one another.ConclusionsAwareness and understanding of IMSCT is imperative to facilitate an early diagnosis and plan management.

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Tài liệu tham khảo

10.1016/j.ncl.2012.09.011

10.1055/s-0033-1357365

10.1586/ern.09.101

10.1002/cncr.27390

10.3171/2010.3.SPINE09399

10.3171/2014.1.PEDS13316

10.1093/neuonc/not038

10.1016/j.wneu.2011.07.016

10.1007/s11060-013-1251-y

10.3171/jns.1979.51.4.0437

10.1227/01.NEU.0000359306.74674.C4

10.3171/jns.1985.62.2.0227

10.1002/1097-0142(196306)16:6<781::AID-CNCR2820160614>3.0.CO;2-M

10.1212/WNL.22.12.1222

10.1007/BF00313146

Mapstone T B, 1992, Neurosurg Clin N Am, 3, 771, 10.1016/S1042-3680(18)30625-9

Riccardi V M Eichner J E Neurofibromatosis: Phenotype, Natural History and Pathogenesis Baltimore, MD Johns Hopkins University Press 1986

10.1097/00006123-199601000-00009

WHO Classification of Tumors of the Central Nervous System. 4th ed Lyon, France International Agency for Research on Cancer (IARC) 2007

10.1007/BF01411560

10.1007/BF02346188

10.1002/glia.440150310

10.1126/science.284.5413.455

10.1073/pnas.93.20.10589

10.1016/0002-9343(64)90107-X

10.1007/s00701-014-2229-z

Barnett H JM Foster J B Hudgson P Syringomyelia In: Walton J N , ed. Major Problems in Neurology Philadelphia, PA W.B. Saunders 1973

Pullicino P, 1982, Neuroradiology, 23, 117, 10.1007/BF00347553

10.1227/00006123-199411000-00010

10.1148/radiology.161.2.3763905

10.1007/BF00327537

10.1007/BF00314647

10.1002/1097-0142(197708)40:2<907::AID-CNCR2820400247>3.0.CO;2-2

Russell D S Rubinstein L J Pathology of Tumors of the Nervous System. 5th ed Baltimore, MD Williams & Wilkins 1989

10.1136/jnnp.28.3.247

10.1007/978-3-642-73294-2_41

10.1177/014107688007301109

10.1001/archneur.1987.00520170054022

Epstein F J, 1990, Neurosurg Clin N Am, 1, 569, 10.1016/S1042-3680(18)30791-5

Sloof J L Kernohan J W MacCarthy C S Primary Intramedullary Tumors of the Spinal Cord and Filum Terminale Philadelphia, PA Saunders 1964

10.3171/jns.1995.83.4.0590

10.1023/A:1006466422143

10.1227/00006123-198912000-00001

10.1302/0301-620X.66B4.6746684

Garrido E, 1977, Surg Neurol, 7, 215

10.3171/foc.1998.4.5.5

10.1097/00006123-200211000-00010

10.3171/jns.1990.72.4.0523

10.1007/s003300050831

Sekula R F, 2000, Semin Spine Surg, 12, 21

Wu Z, 2014, J Orthop Sci

10.1227/00006123-198911000-00003

10.1001/archneur.1976.00500060041009

Yasargil M G, 1976, Surg Neurol, 6, 141

Wyburn-Mason R The Vascular Abnormalities and Tumors of the Spinal Cord and Its Membranes London, UK Henry Kimpton 1943

10.1046/j.1365-2796.1998.00337.x

10.1148/radiology.182.3.1535896

10.1001/archneur.1974.00490320010002

10.1002/1097-0142(197303)31:3<520::AID-CNCR2820310306>3.0.CO;2-2

10.7326/0003-4819-16-1-38

Fromm H, 1974, Paraplegia, 12, 15

Giuffrè R, 1966, Acta Neurochir (Wien), 14, 69, 10.1007/BF01401892

Swanson H S, 1962, Pediatrics, 29, 911, 10.1542/peds.29.6.911

Eichler M E Dacey R G Intramedullary spinal cord tumors In: Bridwell K H DeWald R L , eds. The Textbook of Spinal Surgery Philadelphia, PA Lippincott-Raven 1997 2089–2102

10.1007/BF00604807

10.1097/00006123-199712000-00038

Patel U, 1998, AJNR Am J Neuroradiol, 19, 879

McCormick P C, 1990, Neurosurg Clin N Am, 1, 687, 10.1016/S1042-3680(18)30796-4

10.1097/00006123-199706000-00036

10.1097/00006123-199712000-00040

10.1302/0301-620X.59B2.873974

10.1097/00007632-199702150-00019

Haft H, 1959, Pediatrics, 23, 1152, 10.1542/peds.23.6.1152

Lonstein J E, 1977, Clin Orthop Relat Res, 93

10.2106/00004623-196547020-00001

10.1038/sc.2014.127

10.2214/ajr.152.5.1087

10.1227/00006123-199111000-00002

10.1148/radiology.197.3.7480734

Kahan H, 1996, AJNR Am J Neuroradiol, 17, 143

Colombo N, 1986, Acta Radiol Diagn (Stockh), 769, S734

10.3174/ajnr.A3526

Choucair A K, 1991, Oncology (Williston Park), 5, 25

10.3174/ajnr.A3292

10.1007/s00381-011-1543-5

10.3171/jns.1995.83.3.0480

10.1016/j.crad.2007.07.027

10.1007/s00234-007-0345-7

10.3171/2008.12.SPINE08158

10.1111/j.1755-3768.1929.tb07929.x

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Global Spine Journal

Tập 5 Số 5

425-435

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