Intracerebroventricular Administration of 192IgG-Saporin Alters Expression of Microglia-Associated Genes in the Dorsal But Not Ventral Hippocampus

Yulia V. Dobryakova1, Artem S. Kasianov2, Maria Zaichenko1, M. Yu. Stepanichev1, Ekaterina Chesnokova1, Petr M. Kolosov1, V. А. Markevich1, Alexey P. Bolshakov1,3
1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
2Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
3Pirogov Russian National Research Medical University, Moscow, Russia

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Albrecht, 2000, Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61., J. Biol. Chem., 275, 28929, 10.1074/jbc.M003053200

Berchtold, 2014, Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer Disease., Neurobiol. Aging, 35, 1961, 10.1016/j.neurobiolaging.2014.03.031

Calza, 2003, Neural stem cells and cholinergic neurons: regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor., Proc. Natl. Acad. Sci. U.S.A., 100, 7325, 10.1073/pnas.1132092100

Carnevale, 2007, Microglia-neuron interaction in inflammatory and degenerative diseases: role of cholinergic and noradrenergic systems., CNS Neurol. Disord. Drug Targets, 6, 388, 10.2174/187152707783399193

Cembrowski, 2016, Spatial gene-expression gradients underlie prominent heterogeneity of CA1 pyramidal neurons., Neuron, 89, 351, 10.1016/j.neuron.2015.12.013

Fanselow, 2010, Are the dorsal and ventral hippocampus functionally distinct structures., Neuron, 65, 7, 10.1016/j.neuron.2009.11.031

Francis, 1999, The cholinergic hypothesis of Alzheimer’s disease: a review of progress., J. Neurol. Neurosurg. Psychiatry, 66, 137, 10.1136/jnnp.66.2.137

Grundke-Iqbal, 1986, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology., Proc. Natl. Acad. Sci. U.S.A., 83, 4913, 10.1073/pnas.83.13.4913

Heckers, 1994, Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor., J. Neurosci., 14, 1271, 10.1523/JNEUROSCI.14-03-01271.1994

Herrup, 2015, The case for rejecting the amyloid cascade hypothesis., Nat. Neurosci., 18, 794, 10.1038/nn.4017

Hong, , Complement and microglia mediate early synapse loss in Alzheimer mouse models., Science, 352, 712, 10.1126/science.aad8373

Hong, , New insights on the role of microglia in synaptic pruning in health and disease., Curr. Opin. Neurobiol., 36, 128, 10.1016/j.conb.2015.12.004

Hunter, 2004, Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning., Eur. J. Neurosci., 19, 3305, 10.1111/j.0953-816X.2004.03439.x

Janisiewicz, 2004, Environment-spatial conditional learning in rats with selective lesions of medial septal cholinergic neurons., Hippocampus, 14, 265, 10.1002/hipo.10175

Jeong, 2014, Improvements in memory after medial septum stimulation are associated with changes in hippocampal cholinergic activity and neurogenesis., Biomed Res. Int., 2014, 10.1155/2014/568587

Kanju, 2012, Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus., PLOS ONE, 7, 10.1371/journal.pone.0031073

Knox, 2016, Cholinergic neuronal lesions in the medial septum and vertical limb of the diagonal bands of Broca induce contextual fear memory generalization and impair acquisition of fear extinction., Hippocampus, 26, 718, 10.1002/hipo.22553

Kuczewski, 2005, Selective cholinergic immunolesioning affects synaptic plasticity in developing visual cortex., Eur. J. Neurosci., 21, 1807, 10.1111/j.1460-9568.2005.04014.x

Lee, 2010, Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes., Mol. Brain, 3, 10.1186/1756-6606-3-30

Li, 2009, The sequence alignment/map format and SAMtools., Bioinformatics, 25, 2078, 10.1093/bioinformatics/btp352

Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2., Genome Biol., 15, 10.1186/s13059-014-0550-8

Mi, 2017, PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements., Nucleic Acids Res., 45, D183, 10.1093/nar/gkw1138

Moser, 1995, Spatial learning with a minislab in the dorsal hippocampus., Proc. Natl. Acad. Sci. U.S.A., 92, 9697, 10.1073/pnas.92.21.9697

Paban, , Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult., Neurobiol. Learn. Mem., 95, 441, 10.1016/j.nlm.2011.02.005

Paban, , Neurotrophic signaling molecules associated with cholinergic damage in young and aged rats: environmental enrichment as potential therapeutic agent., Neurobiol. Aging, 32, 470, 10.1016/j.neurobiolaging.2009.03.010

Paban, 2010, Gene expression profile in rat hippocampus with and without memory deficit., Neurobiol. Learn. Mem., 94, 42, 10.1016/j.nlm.2010.03.005

Paxinos, 1998, The Rat Brain in Stereotaxic Coordinates.

Rossner, 1995, 192IgG-saporin immunotoxin-induced loss of cholinergic cells differentially activates microglia in rat basal forebrain nuclei., J. Neurosci. Res., 41, 335, 10.1002/jnr.490410306

Santos, 2012, Neuroprotective and neuroregenerative properties of metallothioneins., IUBMB Life, 64, 126, 10.1002/iub.585

Seeger, 1997, Electron microscopic evidence for microglial phagocytic activity and cholinergic cell death after administration of the immunotoxin 192IgG-saporin in rat., J. Neurosci. Res., 48, 465, 10.1002/(SICI)1097-4547(19970601)48:5<465::AID-JNR7>3.0.CO;2-C

Takashima, 2013, Tauopathies and tau oligomers., J. Alzheimers Dis., 37, 565, 10.3233/JAD-130653

Tan, 2010, Genome wide profiling of altered gene expression in the neocortex of Alzheimer’s disease., J. Neurosci. Res., 88, 1157, 10.1002/jnr.22290

Teles-Grilo Ruivo, 2013, Cholinergic modulation of hippocampal network function., Front. Synaptic Neurosci., 5, 10.3389/fnsyn.2013.00002

Van Kampen, 2010, Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation., Neuropharmacology, 58, 921, 10.1016/j.neuropharm.2009.12.005

Von Der Kammer, 1999, Identification of genes regulated by muscarinic acetylcholine receptors: application of an improved and statistically comprehensive mRNA differential display technique., Nucleic Acids Res., 27, 2211, 10.1093/nar/27.10.2211

Waite, 1995, 192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells., Neuroscience, 65, 463, 10.1016/0306-4522(94)00479-O

Wang, 2016, Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease., Genome Med., 8, 10.1186/s13073-016-0355-3

Zeisel, 2015, Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq., Science, 347, 1138, 10.1126/science.aaa1934

Zhang, 2014, An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex., J. Neurosci., 34, 11929, 10.1523/JNEUROSCI.1860-14.2014