Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages

Springer Science and Business Media LLC - Tập 13 - Trang 1-5 - 2014
Carmen A Molina-Torres1, Alejandra Barba-Marines1, Orestes Valles-Guerra1, Jorge Ocampo-Candiani1, Norma Cavazos-Rocha2, Michael J Pucci3, Jorge Castro-Garza4, Lucio Vera-Cabrera1
1Servicio de Dermatología, Hopital Universitario, UANL, C.P, Monterrey, Mexico
2Departamento de Quimica Analítica, Facultad de Medicina, UANL, Monterrey, Mexico
3Achillion Pharmaceuticals Inc., New Haven, USA
4División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, IMSS, Monterrey, Mexico

Tóm tắt

Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds. Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two compounds significantly decreased the number of intracellular mycobacteria at 0.25X, 1X, 4X and 16X the MIC value. The drugs were tested either in nanoparticules or in free solution. Tedizolid and ACH-702 have a good intracellular killing activity comparable to that of rifampin or moxifloxacin.

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