Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia

Journal of Neuroimmunology - Tập 98 Số 2 - Trang 185-200 - 1999
Jialin Zheng1, Michael R. Thylin1, Anuja Ghorpade1, Huangui Xiong1, Yuri Persidsky1, Robin Cotter1, Douglas Niemann1, Myhanh Che1, Yong-Chun Zeng1, Harris A. Gelbard2, Robin B. Shepard1, Jennifer M. Swartz1, Howard E. Gendelman3,4,1,5
1Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA
2Departments of Neurology and Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
3Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA
4Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA
5Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA

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Adamson, 1996, Immunologic NO synthase: elevation in severe AIDS and induction by HIV-1 gp41, Science, 274, 1917, 10.1126/science.274.5294.1917

Bandres, 1998, Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation, J. Virol., 72, 2500, 10.1128/JVI.72.3.2500-2504.1998

Benveniste, E.N., Shrikant, P., Patton, H.K., Benos, D.J. (1998). Neuroimmunologic mechanisms for disease in AIDS: the role of the astrocyte. In: Gendelman, H.E., Lipton, S., Epstein, L., Swindells, S. (Eds.), The Neurology of AIDS, Chapman & Hall, New York, pp. 130–146.

Bernton, 1992, No direct neuronotoxicity by HIV-1 virions or culture fluids from HIV-1 infected T cells or monocytes, AIDS Res. Hum. Retroviruses, 8, 495, 10.1089/aid.1992.8.495

Bleul, 1996, The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry, Nature, 382, 829, 10.1038/382829a0

Chijiwa, 1990, Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells, J. Biol. Chem., 265, 5267, 10.1016/S0021-9258(19)34116-X

Chomczynski, 1993, A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples, Biotechniques, 15, 532

Ciardo, 1993, Effects of the HIV-1 envelope glycorpotein gp120 in cerebellar cultures [Ca2+]i increases in a glial cell subpopulation, Eur. J. Neurosci., 5, 1711, 10.1111/j.1460-9568.1993.tb00238.x

Davis, 1997, Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5, J. Exp. Med., 186, 1793, 10.1084/jem.186.10.1793

Dawson, 1993, Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures, Proc. Natl. Acad. Sci. USA, 90, 3256, 10.1073/pnas.90.8.3256

Dreyer, 1995, The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid, Eur. J. Neurosci., 7, 2502, 10.1111/j.1460-9568.1995.tb01048.x

Endres, 1996, CD4-independent infection by HIV-2 is mediated by fusin/CXCR4, Cell, 87, 745, 10.1016/S0092-8674(00)81393-8

Feng, 1996, HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor, Science, 272, 872, 10.1126/science.272.5263.872

Finch, 1998, Local calcium signalling by inositol-1,4,5-trisphosphate in purkinje cell dendrites, Nature, 396, 753, 10.1038/25541

Fladmark, 1997, FAS/APO-1 (CD95)-induced apoptosis of primary hepatocytes is inhibited by cAMP, Biochem. Biophys. Res. Commun., 232, 20, 10.1006/bbrc.1997.6214

Francis, 1994, Structure and function of cyclic nucleotide-dependent protein kinase, Annu. Rev. Physiol., 56, 237, 10.1146/annurev.ph.56.030194.001321

Gelbard, 1994, Platelet-activating factor: a candidate human immunodeficiency virus type-1 infection neurotoxin, J. Virol., 68, 4628, 10.1128/JVI.68.7.4628-4635.1994

Gendelman, H.E. (1997). The Neuropathogenesis of HIV-1-Dementia. In: Gendelman, H.E., Lipton, S.A., Epstein, L.G., Swindells, S. (Eds.), The Neurology of AIDS, Chapman & Hall, New York, pp. 1–10.

Gendelman, 1988, Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes, J. Exp. Med., 167, 41, 10.1084/jem.167.4.1428

Ghorpade, 1998, Role of the β-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia, J. Virol., 72, 3351, 10.1128/JVI.72.4.3351-3361.1998

Ghosh, 1995, Calcium signaling in neurons: molecular mechanisms and cellular consequences, Science, 268, 239, 10.1126/science.7716515

Giulian, 1993, The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes, Proc. Natl. Acad. Sci. USA, 90, 2769, 10.1073/pnas.90.7.2769

Glass, 1995, Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlation with dementia, Ann. Neurol., 38, 755, 10.1002/ana.410380510

Gupta, 1998, Chemokine receptors in human endothelial cells, J. Biol. Chem., 273, 4282, 10.1074/jbc.273.7.4282

Harvath, 1991, cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness, J. Immunol., 146, 224, 10.4049/jimmunol.146.1.224

He, 1997, CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia, Nature, 385, 645, 10.1038/385645a0

Hesselgesser, 1998, Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1alpha mediated by the chemokine receptor CXCR4, Curr. Biol., 8, 595, 10.1016/S0960-9822(98)70230-1

Horuk, 1997, Expression of chemokine receptors by subsets of neurons in the central nervous system, J. Immunol., 158, 2882, 10.4049/jimmunol.158.6.2882

Jayaraman, 1997, T cells deficient in inositol 1,4,5-triphosphate receptor are resistant to apoptosis, Mol. Cell. Biol., 17, 3005, 10.1128/MCB.17.6.3005

Kalter, 1991, Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes, J. Immunol., 146, 298, 10.4049/jimmunol.146.1.298

Kerr, 1998, Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex, AIDS, 12, 355, 10.1097/00002030-199804000-00003

Khan, 1996, Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-triphosphate receptor, Science, 273, 503, 10.1126/science.273.5274.503

Koka, 1995, Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor a, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain, J. Exp. Med., 182, 941, 10.1084/jem.182.4.941

Koka, 1995, The mapping of HIV-1 gp160 epitopes required for interleukin-1 and tumor necrosis factor a production in glial cells, J. Neuroimmunol., 57, 179, 10.1016/0165-5728(94)00184-P

Lavi, 1997, CXCR-4 (fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1) is expressed in the human brain in a variety of cell types, including microglia and neurons, Am. J. Pathol., 151, 1035

Lee, 1994, Human astrocytes inhibit cryptoccus neoformans growth by a nitric oxide-mediated mechanism, J. Exp. Med, 180, 365, 10.1084/jem.180.1.365

Lipton, 1998, Neuronal injury associated with HIV-1: approaches to treatment, Annu. Rev. Pharmacol. Toxicol., 38, 159, 10.1146/annurev.pharmtox.38.1.159

Lipton, 1991, Synergistic effects of the HIV coat protein and NMDA receptor-mediated neurotoxicity, Neuron, 7, 111, 10.1016/0896-6273(91)90079-F

Liton, M., Andersson, J., Bjork, L., Fehniger, T., Ulfgren, A.K., and Andersson, U. (1996). Cytoplasmic cytokine staining in individual cells. In: Savelkoul, D.A. (Ed.), Human Cytokine Protocols, Human Press.

Mackay, 1996, Chemokine receptors and T cell chemotaxis, J. Exp. Med., 184, 799, 10.1084/jem.184.3.799

McGeer, 1995, The inflammatory response system of brain:implication for therapy of Alzheimer and other neurodegenerative diseases, Brain Res. Rev., 21, 195, 10.1016/0165-0173(95)00011-9

Merrill, 1992, Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1, J. Virol., 66, 2217, 10.1128/JVI.66.4.2217-2225.1992

Meucci, 1998, Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity, Proc. Natl. Acad. Sci. USA, 95, 14500, 10.1073/pnas.95.24.14500

Nagasawa, 1996, Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1, Nature, 382, 635, 10.1038/382635a0

Nottet, 1995, A regulatory role for astrocytes in HIV-1 encephalitis: an overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-a by activated HIV-1 infected monocytes is attenuated by primary human astrocytes, J. Immunol., 154, 3567, 10.4049/jimmunol.154.7.3567

Oberlin, 1996, The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1, Nature, 382, 833, 10.1038/382833a0

Ohagen, 1999, Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope, J. Virol., 73, 897, 10.1128/JVI.73.2.897-906.1999

Oshima, 1995, Removal of human immunodeficiency virus by an 0.04-μm membrane filter, J. AIDS Hum. Retrovirol., 8, 64

Parvathenani, 1998, Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of Caspase-3, J. Biol. Chem., 273, 6736, 10.1074/jbc.273.12.6736

Perry, 1997, Simultaneous in situ detection of apoptosis and necrosis in monolayer cultures by TUNEL and Trypan Blue staining, Biotechniques, 22, 1102, 10.2144/97226st01

Peterson, 1994, Morphine amplifies HIV-1 expression in human brain cell cultures, J. Neuroimmunol., 20, 83

Shi, 1996, Apoptosis induced by HIV-1 infection of the central nervous system, J. Clin. Invest., 98, 1979, 10.1172/JCI119002

Tardieu, 1992, Human immunodeficiency virus type-1 infected monocytic cells can destroy human neural cells after cell-to-cell adhesion, Ann. Neurol., 32, 11, 10.1002/ana.410320104

Vallat, 1998, Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS, Am. J. Pathol., 152, 167

Winkler, 1998, Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant, Science, 279, 389, 10.1126/science.279.5349.389

Xiong, 1996, Brain-derived peptides inhibits synaptic transmission via GABAB receptors in CA1 area of rats, Brain Res., 737, 188, 10.1016/0006-8993(96)00731-7

Yakovlev, 1997, Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury, J. Neurosci., 17, 7415, 10.1523/JNEUROSCI.17-19-07415.1997

Zheng, 1997, Neuropeptide Y enhance ATP-induced formation of inositol phosphates in chromaffin cells, Biochem. Biophys. Res. Commun., 239, 287, 10.1006/bbrc.1997.7456

Zheng, 1998, CXCR4 mediates neuronal dysfunction by HIV-1 infected macrophage secretory product: importance for HIV-1 associated dementia, Soc. Neurosci. Abstr., 24, 7766

Zheng, J., Thylin, M.R., Persidsky, Y., Xiong, H., Ghorpade, A., Che, M.H., Leisman, G.B., Gendelman, H.E. (1998). Neuronal destruction in HIV-1-associated dementia: secretory products from HIV-1 infected macrophages affect neuronal long term potentiation and deficiencies in neural viability, function and differentiation. J. Virol. (submitted).

Zou, 1998, Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development, Nature, 393, 595, 10.1038/31269