Interferon signaling restrains renal cell carcinoma heterogeneity

Zitvogel, 2015, Type I interferons in anticancer immunity, Nat. Rev. Immunol., 15, 405, 10.1038/nri3845 Boukhaled, 2021, Opposing roles of type I interferons in cancer immunity, Annu. Rev. Pathol., 16, 167, 10.1146/annurev-pathol-031920-093932 De Martino, 2022, Type I interferon induces cancer stem cells-mediated chemotherapy resistance, Oncoimmunology, 11, 10.1080/2162402X.2022.2127274 Borden, 2019, Interferons α and β in cancer: therapeutic opportunities from new insights, Nat. Rev. Drug Discov., 18, 219, 10.1038/s41573-018-0011-2 Perelli, 2023, Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer, Nat. Cancer, 4, 984, 10.1038/s43018-023-00584-1 Turajlic, 2018, Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal, Cell, 173, 581, 10.1016/j.cell.2018.03.057 Bakhoum, 2018, Chromosomal instability drives metastasis through a cytosolic DNA response, Nature, 553, 467, 10.1038/nature25432 Schmitt, 2022, Senescence and cancer – role and therapeutic opportunities, Nat. Rev. Clin. Oncol., 19, 619, 10.1038/s41571-022-00668-4 Yamazaki, 2020, Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy, Nat. Immunol., 21, 1160, 10.1038/s41590-020-0751-0 Klapp, 2023, The DNA damage response and inflammation in cancer, Cancer Discov., 13, 1521, 10.1158/2159-8290.CD-22-1220