Kích thích miễn dịch bẩm sinh của exo-polymers được chuẩn bị từ Cordyceps sinensis bằng phương pháp nuôi cấy ngập nước

Springer Science and Business Media LLC - Tập 80 - Trang 1087-1093 - 2008
Taek Joon Yoon1, Kwang-Soon Shin2, Hyung Joo Suh3, Kwang-Won Yu4
1Department of Food and Nutrition, Yuhan College, Bucheon, South Korea
2Department of Food Science and Biotechnology, Kyonggi University, Suwon, Korea
3Department of Food and Nutrition, Korea University, Seoul, South Korea
4Divison of Food and Biotechnology, Chungju National University, Chungju, Korea

Tóm tắt

Sau khi chúng tôi chuẩn bị exo-polymers (EPS) từ Cordyceps sinensis bằng phương pháp nuôi cấy ngập nước, việc tiêm tĩnh mạch EPS phòng ngừa (i.v.) đã làm giảm đáng kể sự di căn trong thực nghiệm di căn phổi của ung thư đại tràng 26-M3.1. Độc tính tế bào đối với các tế bào khối u Yac-1 của tế bào tiêu diệt tự nhiên (NK), được chuẩn bị bằng tiêm tĩnh mạch EPS (100 μg/mouse), đã được tăng cường đáng kể 2 ngày sau khi điều trị EPS. Khi các tế bào NK bị suy giảm do huyết thanh thỏ chống asialo GM1, ngay cả nhóm EPS cũng hoàn toàn không có tác dụng ức chế đối với sự di căn phổi của tế bào đại tràng 26-M3.1. EPS có thể kích thích hệ miễn dịch bẩm sinh để ức chế sự di căn khối u, và tác dụng chống di căn khối u của nó liên quan đến sự kích hoạt của đại thực bào và tế bào NK.

Từ khóa

#Cordyceps sinensis #exo-polymers #di căn khối u #tế bào NK #hệ miễn dịch bẩm sinh

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