Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals

Environmental Toxicology and Chemistry - Tập 15 Số 2 - Trang 194-202 - 1996
Susan Jobling1, John P. Sumpter1, Dave Sheahan2, Julia A. Osborne2, Peter Matthiessen2
1Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
2Fisheries Laboratory, Directorate of Fisheries Research, Ministry of Agriculture, Fisheries and Food, Remembrance Avenue, Burnham on Crouch, Essex, CM0 8HA, UK

Tóm tắt

Abstract

It is becoming evident that an increasing number of widely used industrial and agricultural chemicals are estrogenic. The biodegradation products of a major group of nonionic surfactants, the alkylphenol polyethoxylates, are one such group. Some of these chemicals are widespread aquatic pollutants, and bioconcentrate in aquatic biota. Exposure of male rainbow trout (Oncorhynchus mykiss) to four different alkylphenolic chemicals caused synthesis of vitellogenin, a process normally dependent on endogenous estrogens, and a concomitant inhibition of testicular growth. The magnitude of these estrogenic effects was dependent on the estrogenic potency of the chemical, the stage of reproductive development of the fish, and the concentration of the chemical in the water. These results support the contention that exposure of wildlife to environmentally persistent estrogenic chemicals can result in deleterious reproductive consequences.

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Tài liệu tham khảo

10.1126/science.8023147

Raloff J., 1994, That feminine touch: Are men suffering from prenatal or childhood exposures to “hormonal” toxicants?, Science News, 145, 49, 10.2307/3977991

10.2307/3978271

Colborn T., 1992, Advances in Modern Environmental Toxicology

McLachlan J. A., 1980, Estrogens in the Environment

McLachlan J. A., 1985, Estrogens in the Environment II

Soto A. M., 1991, p‐Nonylphenol: An estrogenic xenobiotic released from “modified” polystyrene, Environ. Health Perspect., 92, 167, 10.1289/ehp.9192167

10.1016/0166-445X(93)90064-8

10.1210/endo.132.6.8504731

10.1021/es00161a011

10.1080/09593339109385102

Naylor C. G., 1992, Environmental fate of alkylphenol ethoxylates, Soap/Cosmetics/Chemical Specialities, 72, 27

10.1080/03067319208027027

10.1002/etc.5620130507

10.1126/science.6740328

Chemical Manufacturers Association, 1994, Alkylphenol ethoxylates in the environment

Giger W., 1987, Behaviour of alkylphenol polyethoxylate surfactants and of nitrilotriacetate in sewage treatment, Water. Sci. Technol., 19, 449, 10.2166/wst.1987.0225

10.1016/0269-7491(90)90108-O

10.1016/0269-7491(93)90096-7

10.1210/endo.135.1.8013351

Billard R., 1992, Reproduction in rainbow trout: Sex differentiation, dynamics of gametogenesis, biology and preservation of gametes, Aquaculture, 100, 262, 10.1016/0044-8486(92)90385-X

Trudeau V. L., 1991, Testosterone and estradiol potentiate the serum gonadatropin response to gonadotropin releasing hormone in goldfish, Biol. Reprod., 48, 951, 10.1095/biolreprod44.6.951

10.1139/o83-102

10.1016/0016-6480(83)90160-0

McLachlan J. A., 1976, Advances in Modern Toxicology, 423

Newbold R. R., 1985, Estrogens in the Environment, 288

10.1126/science.7256288

10.1289/ehp.94102680

10.1016/0044-8486(88)90156-1

10.1016/0166-445X(86)90004-4

10.1016/0166-445X(85)90024-4

Sheahan D. A., 1994, The effects of low levels of 17α‐ethynylestradiol upon plasma vitellogenin levels in male and female rainbow trout, Oncorhynchus mykiss (Walbaum) held at two acclimation temperatures, 99

Sumpter J. P., 1985, Trends in Comparative Endocrinology, 355

10.1016/0016-6480(89)90054-3

Flouriot G., 1993, Monolayer and aggregate cultures of rainbow trout hepatocytes: Long term and stable liver‐specific expression in aggregates, J. Cell Sci., 105, 407, 10.1242/jcs.105.2.407

10.1139/z81-201

10.1016/0303-7207(93)90040-Q

Xiong F., 1994, The chinook salmon gonadotropin IIb subunit gene contains a strong minimal promoter with a proximal negative element, Mol. Endocrinol., 8, 771

10.1210/me.8.6.782

10.1016/S1546-5098(08)60305-2

10.1016/0044-8486(89)90207-X

10.1016/0044-8486(86)90208-5

10.1016/0305-0491(85)90312-8

Washburn B. S., 1993, Effects of estrogen on gluconeogenesis and related parameters in male rainbow trout, Am. J. Physiol., 264, R720

10.1002/jez.1402460209

10.1002/jez.1402480211

10.1677/joe.0.1310229

Specker J. L., 1993, Perspectives in Comparative Endocrinology, 304

10.1006/gcen.1994.1089

10.1021/ac00285a018

10.1007/BF02635812

10.1016/0043-1354(94)90200-3

10.1021/es00054a016

10.1021/ac00290a035

Warhurst A. M., 1995, An environmental assessment of alkylphenol ethoxylates and alkylphenols

10.1016/0043-1354(94)90201-1

10.1007/BF00214159

10.1021/es00066a004

10.1016/0304-4203(90)90020-D

10.1016/0045-6535(93)90214-P

10.1289/ehp.94102380

Sumpter J. P.andS.Jobling.1996.Vitellogenesis as a biomarker for oestrogenic contamination of the aquatic environment.Environ. Health Perspect. (in press).

10.1080/02757549408038554