Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

American Association for the Advancement of Science (AAAS) - Tập 261 Số 5127 - Trang 1445-1448 - 1993
Gunasegaran Karupiah1, Q W Xie2, R. Mark L. Buller1, Carl Nathan2, Cornelio Duarte1, John D. MacMicking2
1Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
2Beatrice and Samuel A. Seaver Laboratory, Division of Hematology-Oncology, Department of Medicine, Cornell University Medical College, New York, NY 10021.

Tóm tắt

Interferons (IFNs) induce antiviral activity in many cell types. The ability of IFN-γ to inhibit replication of ectromelia, vaccinia, and herpes simplex-1 viruses in mouse macrophages correlated with the cells' production of nitric oxide (NO). Viral replication was restored in IFN-γ-treated macrophages exposed to inhibitors of NO synthase. Conversely, epithelial cells with no detectable NO synthesis restricted viral replication when transfected with a complementary DNA encoding inducible NO synthase or treated with organic compounds that generate NO. In mice, an inhibitor of NO synthase converted resolving ectromelia virus infection into fulminant mousepox. Thus, induction of NO synthase can be necessary and sufficient for a substantial antiviral effect of IFN-γ.

Từ khóa


Tài liệu tham khảo

BEATTIE, E, VACCINIA VIRUS-ENCODED EIF-2-ALPHA HOMOLOG ABROGATES THE ANTIVIRAL EFFECT OF INTERFERON, VIROLOGY 183: 419 (1991).

BULLER, RML, POXVIRUS PATHOGENESIS, MICROBIOLOGICAL REVIEWS 55: 80 (1991).

CHANG, H.W., THE E3L GENE OF VACCINIA VIRUS ENCODES AN INHIBITOR OF THE INTERFERON-INDUCED, DOUBLE-STRANDED RNA-DEPENDENT PROTEIN-KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 4825 (1992).

10.1126/science.7680491

CROEN, K.D., EVIDENCE FOR AN ANTIVIRAL EFFECT OF NITRIC-OXIDE - INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION, JOURNAL OF CLINICAL INVESTIGATION 91: 2446 (1993).

DAVIES, M.V., THE VACCINIA VIRUS K3L-GENE PRODUCT POTENTIATES TRANSLATION BY INHIBITING DOUBLE-STRANDED-RNA-ACTIVATED PROTEIN-KINASE AND PHOSPHORYLATION OF THE ALPHA SUBUNIT OF EUKARYOTIC INITIATION FACTOR-II, JOURNAL OF VIROLOGY 66: 1943 (1992).

DAVIES, M.V., THE E3L AND K3L VACCINIA VIRUS GENE-PRODUCTS STIMULATE TRANSLATION THROUGH INHIBITION OF THE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN-KINASE BY DIFFERENT MECHANISMS, JOURNAL OF VIROLOGY 67: 1688 (1993).

DING, A.H., RELEASE OF REACTIVE NITROGEN INTERMEDIATES AND REACTIVE OXYGEN INTERMEDIATES FROM MOUSE PERITONEAL-MACROPHAGES - COMPARISON OF ACTIVATING CYTOKINES AND EVIDENCE FOR INDEPENDENT PRODUCTION, JOURNAL OF IMMUNOLOGY 141: 2407 (1988).

DRAPIER, J.C., INTERFERON-GAMMA AND TUMOR NECROSIS FACTOR INDUCE THE L-ARGININE-DEPENDENT CYTO-TOXIC EFFECTOR MECHANISM IN MURINE MACROPHAGES, EUROPEAN JOURNAL OF IMMUNOLOGY 18: 1587 (1988).

HASSANAIN, H.H., DIFFERENTIAL REGULATION OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE GENE-EXPRESSION BY INTERFERON-GAMMA AND INTERFERON-ALPHA - ANALYSIS OF THE REGULATORY REGION OF THE GENE AND IDENTIFICATION OF AN INTERFERON-GAMMA-INDUCIBLE DNA-BINDING FACTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 5077 (1993).

HECK, D.E., EPIDERMAL GROWTH-FACTOR SUPPRESSES NITRIC-OXIDE AND HYDROGEN-PEROXIDE PRODUCTION BY KERATINOCYTES - POTENTIAL ROLE FOR NITRIC-OXIDE IN THE REGULATION OF WOUND-HEALING, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 21277 (1992).

Hibbs, J. B., Nitric Oxide from L-Arginine: A Bioregulatory System: 189 (1990).

10.1126/science.2432665

IGNARRO, L.J., MECHANISM OF VASCULAR SMOOTH-MUSCLE RELAXATION BY ORGANIC NITRATES, NITRITES, NITROPRUSSIDE AND NITRIC-OXIDE - EVIDENCE FOR THE INVOLVEMENT OF S-NITROSOTHIOLS AS ACTIVE INTERMEDIATES, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 218: 739 (1981).

ISRAEL, N, REDOX STATUS OF CELLS INFLUENCES CONSTITUTIVE OR INDUCED NF-KAPPA-B TRANSLOCATION AND HIV LONG TERMINAL REPEAT ACTIVITY IN HUMAN T-CELL AND MONOCYTIC CELL-LINES, JOURNAL OF IMMUNOLOGY 149: 3386 (1992).

KARUPIAH, G, INTERFERON-GAMMA IS INVOLVED IN THE RECOVERY OF ATHYMIC NUDE-MICE FROM RECOMBINANT VACCINIA VIRUS INTERLEUKIN-2 INFECTION, JOURNAL OF EXPERIMENTAL MEDICINE 172: 1495 (1990).

KARUPIAH, G, IMPORTANCE OF INTERFERONS IN RECOVERY FROM MOUSEPOX, JOURNAL OF VIROLOGY 67: 4214 (1993).

KARUPIAH G unpublished data.

KWON, N.S., INHIBITION OF TUMOR-CELL RIBONUCLEOTIDE REDUCTASE BY MACROPHAGE-DERIVED NITRIC-OXIDE, JOURNAL OF EXPERIMENTAL MEDICINE 174: 761 (1991).

LANDER, H.M., ACTIVATION OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS BY NITRIC OXIDE-GENERATING COMPOUNDS, JOURNAL OF IMMUNOLOGY 150: 1509 (1993).

LEPOIVRE, M, ALTERATIONS OF RIBONUCLEOTIDE REDUCTASE-ACTIVITY FOLLOWING INDUCTION OF THE NITRITE-GENERATING PATHWAY IN ADENOCARCINOMA CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 14143 (1990).

MONCADA, S, NITRIC-OXIDE - PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY, PHARMACOLOGICAL REVIEWS 43: 109 (1991).

NATHAN, C, NITRIC-OXIDE AS A SECRETORY PRODUCT OF MAMMALIAN-CELLS, FASEB JOURNAL 6: 3051 (1992).

Nathan C. Inflammation: Basic Principles and Clinical Correlates 2 265 (1992).

NATHAN, C.F., ROLE OF NITRIC-OXIDE SYNTHESIS IN MACROPHAGE ANTIMICROBIAL ACTIVITY, CURRENT OPINION IN IMMUNOLOGY 3: 65 (1991).

NGUYEN, T, DNA DAMAGE AND MUTATION IN HUMAN-CELLS EXPOSED TO NITRIC-OXIDE INVITRO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 3030 (1992).

PAEZ, E, RESISTANCE OF VACCINIA VIRUS TO INTERFERON IS RELATED TO AN INTERFERENCE PHENOMENON BETWEEN THE VIRUS AND THE INTERFERON SYSTEM, VIROLOGY 134: 12 (1984).

POMERANTZ, R.J., LIPOPOLYSACCHARIDE IS A POTENT MONOCYTE MACROPHAGE-SPECIFIC STIMULATOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXPRESSION, JOURNAL OF EXPERIMENTAL MEDICINE 172: 253 (1990).

ROBERTS, A.B., ROLE OF NITRIC-OXIDE IN ANTAGONISTIC EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA AND INTERLEUKIN-1-BETA ON THE BEATING RATE OF CULTURED CARDIAC MYOCYTES, MOLECULAR ENDOCRINOLOGY 6: 1921 (1992).

RUBY, J, THE ANTIVIRAL ACTIVITY OF IMMUNE CD8+ T-CELLS IS DEPENDENT ON INTERFERON-GAMMA, LYMPHOKINE AND CYTOKINE RESEARCH 10: 353 (1991).

SAMUEL, C.E., ANTIVIRAL ACTIONS OF INTERFERON - INTERFERON-REGULATED CELLULAR PROTEINS AND THEIR SURPRISINGLY SELECTIVE ANTIVIRAL ACTIVITIES, VIROLOGY 183: 1 (1991).

SEN, G.C., THE INTERFERON SYSTEM - A BIRDS-EYE-VIEW OF ITS BIOCHEMISTRY, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 5017 (1992).

SETHI, K.K., CONTRIBUTION OF MACROPHAGE ARGINASE IN THE INTRINSIC RESTRICTION OF HERPES-SIMPLEX VIRUS-REPLICATION IN PERMISSIVE MACROPHAGE CULTURES INDUCED BY GAMMA-INTERFERON CONTAINING PRODUCTS OF ACTIVATED SPLEEN-CELLS, IMMUNOBIOLOGY 165: 459 (1983).

10.1126/science.1281928

Vilcek, J., Peptide Growth Factors and Their Receptors 2: 3 (1990).

WERNERFELMAYER, G, TETRAHYDROBIOPTERIN-DEPENDENT FORMATION OF NITRITE AND NITRATE IN MURINE FIBROBLASTS, JOURNAL OF EXPERIMENTAL MEDICINE 172: 1599 (1990).

WILDY, P, INHIBITION OF HERPES-SIMPLEX VIRUS MULTIPLICATION BY ACTIVATED MACROPHAGES - A ROLE FOR ARGINASE, INFECTION AND IMMUNITY 37: 40 (1982).

10.1126/science.1948068

10.1126/science.1373522

XIE Q.W. unpublished data.

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American Association for the Advancement of Science (AAAS)

Tập 261 Số 5127

1445-1448

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