Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

American Association for the Advancement of Science (AAAS) - Tập 251 Số 4989 - Trang 85-87 - 1991
Keith A. Trujillo1, Huda Akil1
1Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0720.

Tóm tắt

The N -methyl-D-aspartate (NMDA) subtype of the glutamate receptor is an important mediator of several forms of neural and behavioral plasticity. The present studies examined whether NMDA receptors might be involved in the development of opiate tolerance and dependence, two examples of behavioral plasticity. The noncompetitive NMDA receptor antagonist MK-801 attenuated the development of tolerance to the analgesic effect of morphine without affecting acute morphine analgesia. In addition, MK-801 attenuated the development of morphine dependence as assessed by naloxone-precipitated withdrawal. These results suggest that NMDA receptors may be important in the development of opiate tolerance and dependence.

Từ khóa


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