Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship

Clinical Infectious Diseases - Tập 44 Số 2 - Trang 159-177 - 2007
Timothy H. Dellit1, Robert C. Owens2, John E. McGowan3, Dale N. Gerding4, Robert A. Weinstein5, John P. Burke6, W. Charles Huskins7, David L. Paterson8, Neil O. Fishman9, Christopher Carpenter10, Patrick J. Brennan9, Marianne Billeter11, Thomas M. Hooton12
1 Harborview Medical Center and the University of Washington, Seattle
2Maine Medical Center, Portland
3Emory University, Atlanta, Georgia
4 Hines Veterans Affairs Hospital and Loyola University Stritch School of Medicine, Hines
5 Stroger (Cook County) Hospital and Rush University Medical Center, Chicago, Illinois
6University of Utah, Salt Lake City
7Mayo Clinic, College of Medicine, Rochester, Minnesota
8University of Pittsburgh Medical Center, Pittsburgh
9University of Pennsylvania, Philadelphia, Pennsylvania
10William Beaumont Hospital, Royal Oak, Michigan
11Ochsner Health System, New Orleans, Louisiana
12University of Miami, Miami, Florida

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Kish, 2001, Guide to development of practice guidelines, Clin Infect Dis, 32, 851, 10.1086/319366

Schentag, 1993, Changes in antimicrobial agent usage resulting from interactions among clinical pharmacy, the infectious disease division, and the microbiology laboratory, Diagn Microbiol Infect Dis, 16, 255, 10.1016/0732-8893(93)90119-R

Carling, 2003, Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years, Infect Control Hosp Epidemiol, 24, 699, 10.1086/502278

LaRocco, 2003, Concurrent antibiotic review programs—a role for infectious diseases specialists at small community hospitals, Clin Infect Dis, 37, 742, 10.1086/377286

Ansari, 2003, Outcomes of an intervention to improve hospital antibiotic prescribing: interrupted time series with segmented regression analysis, J Antimicrob Chemother, 52, 842, 10.1093/jac/dkg459

Ruttimann, 2004, Long-term antibiotic cost savings from a comprehensive intervention program in a medical department of a university-affiliated teaching hospital, Clin Infect Dis, 38, 348, 10.1086/380964

Lutters, 2004, Effect of a comprehensive, multidisciplinary, educational program on the use of antibiotics in a geriatric university hospital, J Am Geriatr Soc, 52, 112, 10.1111/j.1532-5415.2004.52019.x

Scheckler, 1970, Antibiotic usage in seven community hospitals, JAMA, 213, 264, 10.1001/jama.1970.03170280024004

Marr, 1988, Guidelines for improving the use of antimicrobial agents in hospitals: a statement by the Infectious Diseases Society of America, J Infect Dis, 157, 869, 10.1093/infdis/157.5.869

Shlaes, 1997, Society for Healthcare Epidemiology of America and Infectious Diseases Society of America joint committee on the prevention of antimicrobial resistance: guidelines for the prevention of antimicrobial resistance in hospitals, Clin Infect Dis, 25, 584, 10.1086/513766

Lawton, 2000, Practices to improve antimicrobial use at 47 US hospitals: the status of the 1997 SHEA/IDSA position paper recommendations, Infect Control Hosp Epidemiol, 21, 256, 10.1086/501754

Girouard, 2001, Infection control programs at children's hospitals: a description of structures and processes, Am J Infect Control, 29, 145, 10.1067/mic.2001.115406

Sunenshine, 2004, Role of infectious disease consultants in management of antimicrobial use in hospitals, Clin Infect Dis, 38, 934, 10.1086/382358

Burke, 2003, Infection control: a problem for patient safety, N Engl J Med, 348, 651, 10.1056/NEJMhpr020557

John, 1997, Programmatic role of the infectious diseases physician in controlling antimicrobial costs in the hospital, Clin Infect Dis, 24, 471, 10.1093/clinids/24.3.471

Reimann, 1961, The misuse of antimicrobics, Med Clin North Am, 45, 849, 10.1016/S0025-7125(16)33847-0

Kislak, 1964, Hospital-acquired infections and antibiotic usage in the Boston City Hospital—January, 1964, N Engl J Med, 271, 834, 10.1056/NEJM196410152711608

Roberts, 1972, The rational and irrational use of systemic antimicrobial drugs, Am J Hosp Pharm, 29, 828

McGowan, 1983, Antimicrobial resistance in hospital organisms and its relation to antibiotic use, Rev Infect Dis, 5, 1033, 10.1093/clinids/5.6.1033

Monroe, 2000, Antimicrobial use and bacterial resistance, Curr Opin Microbiol, 3, 496, 10.1016/S1369-5274(00)00129-6

Barbosa, 2000, The impact of antibiotic use on resistance development and persistence, Drug Resistance Updates, 3, 303, 10.1054/drup.2000.0167

Paterson, 2004, “Collateral damage” from cephalosporin or quinolone antibiotic therapy, Clin Infect Dis, 38, S341, 10.1086/382690

Courcol, 1989, A seven year survey of antibiotic susceptibility and its relationship with usage, J Antimicrob Chemother, 23, 441, 10.1093/jac/23.3.441

Chow, 1991, Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy, Ann Intern Med, 115, 585, 10.7326/0003-4819-115-8-585

Conus, 1992, Relationship between ceftriaxone use and resistance of Enterobacter species, J Clin Pharm Ther, 17, 303, 10.1111/j.1365-2710.1992.tb01308.x

Seppala, 1997, The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland, N Engl J Med, 337, 441, 10.1056/NEJM199708143370701

Rahal, 1998, Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella, JAMA, 280, 1233, 10.1001/jama.280.14.1233

Neuhauser, 2003, Antibiotic resistance among gram-negative bacilli in US intensive care units, JAMA, 289, 885, 10.1001/jama.289.7.885

Muller, 2003, Relationship between spread of methicillin-resistant Staphylococcus aureus and antimicrobial use in a French university hospital, Clin Infect Dis, 36, 971, 10.1086/374221

Polk, 2004, Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities, Clin Infect Dis, 39, 497, 10.1086/422647

Paterson, 2004, International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial infections, Ann Intern Med, 140, 26, 10.7326/0003-4819-140-1-200401060-00008

McGowan, 2001, Economic impact of antimicrobial resistance, Emerg Infect Dis, 7, 286, 10.3201/eid0702.010228

Cosgrove, 2003, The impact of antimicrobial resistance on health and economic outcomes, Clin Infect Dis, 36, 1433, 10.1086/375081

Cosgrove, 2003, Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis, Clin Infect Dis, 36, 53, 10.1086/345476

Melzer, 2003, Is methicillin-resistant Staphylococcus aureus more virulent than methicillin-susceptible S. aureus?. A comparative cohort study of British patients with nosocomial infection and bacteremia, Clin Infect Dis, 37, 1453, 10.1086/379321

Engemann, 2003, Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection, Clin Infect Dis, 36, 592, 10.1086/367653

Chaix, 1999, Control of endemic methicillin-resistant Staphylococcus aureus: a cost-benefit analysis in an intensive care unit, JAMA, 282, 1745, 10.1001/jama.282.18.1745

Stosor, 1998, Enterococcus faecium bacteremia: does vancomycin resistance make a difference?, Arch Intern Med, 158, 522, 10.1001/archinte.158.5.522

DiazGranados, 2005, Comparison of mortality associated with vancomycin-resistant and vancomycin-susceptible enterococcal bloodstream infections: a meta-analysis, Clin Infect Dis, 41, 327, 10.1086/430909

Salgado, 2003, Outcomes associated with vancomycin-resistant enterococci: a meta-analysis, Infect Control Hosp Epidemiol, 24, 690, 10.1086/502271

Cosgrove, 2006, The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs, Clin Infect Dis, 42, 82, 10.1086/499406

Cosgrove, 2002, Health and economic outcomes of the emergence of third-generation cephalosporin resistance in Enterobacter species, Arch Intern Med, 162, 185, 10.1001/archinte.162.2.185

Falagas, 2005, Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections, Clin Infect Dis, 40, 1333, 10.1086/429323

Institute of Medicine, 1998, Antimicrobial drug resistance: issues and options. Workshop report

Ramsay, 2003, Room for improvement: a systematic review of the quality of evaluations of interventions to improve hospital antibiotic prescribing, J Antimicrob Chemother, 52, 764, 10.1093/jac/dkg460

Muto, 2003, SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and Enterococcus, Infect Control Hosp Epidemiol, 24, 362, 10.1086/502213

Healthcare Infection Control Practices Advisory Committee, 2006, Management of multidrug-resistant organisms in healthcare settings

Goldmann, 1996, Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals: a challenge to hospital leadership, JAMA, 275, 234, 10.1001/jama.1996.03530270074035

Solomon, 2001, Academic detailing to improve use of broad-spectrum antibiotics at an academic medical center, Arch Intern Med, 161, 1897, 10.1001/archinte.161.15.1897

Fraser, 1997, Antibiotic optimization: an evaluation of patient safety and economic outcomes, Arch Intern Med, 157, 1689, 10.1001/archinte.1997.00440360105012

Seligman, 1981, Reduction in antibiotic costs by restricting use of an oral cephalosporin, Am J Med, 71, 941, 10.1016/0002-9343(81)90304-1

Britton, 1981, Cost containment through restriction of cephalosporins, Am J Hosp Pharm, 38, 1897

Hayman, 1985, Controlling cephalosporin and aminoglycoside costs through pharmacy and therapeutics committee restrictions, Am J Hosp Pharm, 42, 1343

Woodward, 1987, Antibiotic cost savings from formulary restrictions and physician monitoring in a medical-school-affiliated hospital, Am J Med, 83, 817, 10.1016/0002-9343(87)90636-X

Coleman, 1991, Cost-effectiveness of prospective and continuous parenteral antibiotic control: Experience at the Palo Alto Veterans Affairs Medical Center from 1987 to 1989, Am J Med, 90, 439, 10.1016/0002-9343(91)90603-U

Maswoswe, 1995, Enforcing a policy for restricting antimicrobial drug use, Am J Health Syst Pharm, 52, 1433, 10.1093/ajhp/52.13.1433

White, 1997, Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes, Clin Infect Dis, 25, 230, 10.1086/514545

Pear, 1994, Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use, Ann Intern Med, 120, 272, 10.7326/0003-4819-120-4-199402150-00003

Quale, 1996, Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci, Clin Infect Dis, 23, 1020, 10.1093/clinids/23.5.1020

Bamberger, 1992, Impact of voluntary vs. enforced compliance of third-generation cephalosporin use in a teaching hospital, Arch Intern Med, 152, 554, 10.1001/archinte.1992.00400150078014

Anglim, 1997, Effect of a vancomycin restriction policy on ordering practices during an outbreak of vancomycin-resistant Enterococcus faecium, Arch Intern Med, 157, 1132, 10.1001/archinte.1997.00440310098010

May, 2000, Reduction of vancomycin-resistant enterococcal infections by limitation of broad-spectrum cephalosporin use in a trauma and burn intensive care unit, Shock, 14, 259, 10.1097/00024382-200014030-00003

Stiefel, 2004, Effect of the increasing use of piperacillin/tazobactam on the incidence of vancomycin-resistant enterococci in four academic medical centers, Infect Control Hosp Epidemiol, 25, 380, 10.1086/502409

Lautenbach, 2003, Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: impact of progressive restrictions on use of vancomycin and third-generation cephalosporins, Clin Infect Dis, 36, 440, 10.1086/346153

de Man, 2000, An antibiotic policy to prevent emergence of resistant bacilli, Lancet, 355, 973, 10.1016/S0140-6736(00)90015-1

Toltzis, 1998, Antibiotic restriction does not alter endemic colonization with resistant gram-negative rods in a pediatric intensive care unit, Crit Care Med, 26, 1893, 10.1097/00003246-199811000-00035

DeVito, 1985, Effect of formulary restriction of cefotaxime usage, Arch Intern Med, 145, 1053, 10.1001/archinte.1985.00360060117018

Gross, 2001, Impact of a hospital-based antimicrobial management program on clinical and economic outcomes, Clin Infect Dis, 33, 289, 10.1086/321880

Burke, 1998, Antibiotic resistance—squeezing the balloon?, JAMA, 280, 1270, 10.1001/jama.280.14.1270

Friedrich, 1999, Impact of use of multiple antimicrobials on changes in susceptibility of gram-negative aerobes, Clin Infect Dis, 28, 1017, 10.1086/514747

Bantar, 2003, A hospitalwide intervention program to optimize the quality of antibiotic use: impact on prescribing practice, antibiotic consumption, cost savings, and bacterial resistance, Clin Infect Dis, 37, 180, 10.1086/375818

Belongia, 2005, Impact of statewide program to promote appropriate antimicrobial drug use, Emerg Infect Dis, 11, 912

Girotti, 1990, Antibiotic handbook and pre-printed perioperative order forms for surgical antibiotic prophylaxis: do they work?, Can J Surg, 33, 385

Lomas, 1989, Do practice guidelines guide practice?. The effect of a consensus statement of the practice of physicians, N Engl J Med, 321, 1306, 10.1056/NEJM198911093211906

Marrie, 2000, A controlled trial of a critical pathway for treatment of community-acquired pneumonia, JAMA, 283, 749, 10.1001/jama.283.6.749

Price, 1999, Evaluation of clinical practice guidelines on outcome of infection in patients in the surgical intensive care unit, Crit Care Med, 27, 2118, 10.1097/00003246-199910000-00007

Kollef, 1999, Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients, Chest, 115, 462, 10.1378/chest.115.2.462

Fagon, 2000, Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia, Ann Intern Med, 132, 621, 10.7326/0003-4819-132-8-200004180-00004

Singh, 2000, Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit, Am J Respir Crit Care Med, 162, 505, 10.1164/ajrccm.162.2.9909095

Ibrahim, 2001, Experience with a clinical guideline for the treatment of ventilator-associated pneumonia, Crit Care Med, 29, 1109, 10.1097/00003246-200106000-00003

Chastre, 2003, Comparison of 8 vs. 15 days of antibiotic therapy for ventilator-associated pneumonia in adults, JAMA, 290, 2588, 10.1001/jama.290.19.2588

South, 2003, A simple intervention to improve hospital antibiotic prescribing, Med J Aust, 178, 207, 10.5694/j.1326-5377.2003.tb05163.x

Gerding, 2000, Antimicrobial cycling: lessons learned from the aminoglycoside experience, Infect Control Hosp Epidemiol, 21, 12, 10.1086/503168

Hodges, 2001, Antimicrobial cycling: the future or a fad?, Ann Pharmacother, 35, 1224, 10.1345/aph.10243

Fridkin, 2003, Routine cycling of antimicrobial agents as an infection-control measure, Clin Infect Dis, 36, 1438, 10.1086/375082

Dubberke, 2004, Cycling and other strategies to slow and reverse antibiotic resistance, Infect Med, 21, 544

Moody, 1982, Long-term amikacin use: effects on aminoglycoside susceptibility patterns of gram-negative bacilli, JAMA, 248, 1199, 10.1001/jama.1982.03330100037027

Betts, 1984, Five-year surveillance of aminoglycoside usage in a university hospital, Ann Intern Med, 100, 219, 10.7326/0003-4819-100-2-219

Young, 1985, Antibiotic resistance patterns during aminoglycoside restriction, Am J Med Sci, 290, 223, 10.1097/00000441-198512000-00001

Berk, 1986, Clinical and microbiologic consequences of amikacin use during a 42-month period, Arch Intern Med, 146, 538, 10.1001/archinte.1986.00360150160020

Van Landuyt, 1986, Surveillance of aminoglycoside resistance, Am J Med, 80, 76, 10.1016/0002-9343(86)90483-3

Gerding, 1991, Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital, Antimicrob Agents Chemother, 35, 1284, 10.1128/AAC.35.7.1284

King, 1992, Alterations in the microbial flora and in the incidence of bacteremia at a university hospital after adoption of amikacin as the sole formulary aminoglycoside, Clin Infect Dis, 14, 908, 10.1093/clinids/14.4.908

Kollef, 1997, Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia, Am J Respir Crit Care Med, 156, 1040, 10.1164/ajrccm.156.4.9701046

Gruson, 2000, Rotation and restricted use of antibiotics in a medical intensive care unit: impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria, Am J Respir Crit Care Med, 162, 837, 10.1164/ajrccm.162.3.9905050

Raymond, 2001, Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit, Crit Care Med, 29, 1101, 10.1097/00003246-200106000-00001

Bonhoeffer, 1997, Evaluating treatment protocols to prevent antibiotic resistance, Proc Natl Acad Sci U S A, 94, 12106, 10.1073/pnas.94.22.12106

Bergstrom, 2004, Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals, Proc Natl Acad Sci U S A, 7, 13101

Martinez, 2006, Comparison of antimicrobial cycling and mixing strategies in two medical intensive care units, Crit Care Med, 34, 329, 10.1097/01.CCM.0000195010.63855.45

Durbin, 1981, Improved antibiotic usage following introduction of a novel prescription system, JAMA, 246, 1796, 10.1001/jama.1981.03320160028024

Echols, 1984, The use of an antibiotic order form for antibiotic utilization review: influence on physicians' prescribing patterns, J Infect Dis, 150, 803, 10.1093/infdis/150.6.803

Classen, 1992, The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection, N Engl J Med, 326, 281, 10.1056/NEJM199201303260501

Bratzler, 2004, Antimicrobial prophylaxis for surgery: an advisory statement from the national surgical infection prevention project, Clin Infect Dis, 38, 1706, 10.1086/421095

Bolon, 2005, An antibiotic order form intervention does not improve or reduce vancomycin use, Pediatr Infect Dis J, 24, 1053, 10.1097/01.inf.0000190025.61037.6c

Hyle, 2005, Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae, Arch Intern Med, 165, 1375, 10.1001/archinte.165.12.1375

Harbarth, 2003, Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis, Am J Med, 115, 529, 10.1016/j.amjmed.2003.07.005

American Thoracic Society and Infectious Diseases Society of America, 2005, Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia, Am J Respir Crit Care Med, 171, 388, 10.1164/rccm.200405-644ST

Bodey, 1985, Pseudomonas bacteremia: retrospective analysis of 410 episodes, Arch Intern Med, 145, 1621, 10.1001/archinte.1985.00360090089015

Nichols, 1985, The emergence of resistance to beta-lactam antibiotics during treatment of Pseudomonas aeruginosa lower respiratory tract infections: is combination therapy the solution?, Chemioterapia, 4, 102

Milatovic, 1987, Development of resistance during antibiotic therapy, Eur J Clin Microbiol, 6, 234, 10.1007/BF02017607

Hilf, 1989, Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients, Am J Med, 87, 540, 10.1016/S0002-9343(89)80611-4

Korvick, 1992, Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy, Antimicrob Agents Chemother, 36, 2639, 10.1128/AAC.36.12.2639

Vidal, 1996, Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment: analysis of 189 patients, Arch Intern Med, 156, 2121, 10.1001/archinte.1996.00440170139015

Leibovici, 1997, Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study, Antimicrob Agents Chemother, 41, 1127, 10.1128/AAC.41.5.1127

Chatzinikolaou, 2000, Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer: retrospective analysis of 245 episodes, Arch Intern Med, 160, 501, 10.1001/archinte.160.4.501

Paul, 2004, Beta-lactam monotherapy versus beta-lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomized trials, BMJ, 328, 668, 10.1136/bmj.38028.520995.63

Safdar, 2004, Does combination antimicrobial therapy reduce mortality in gram-negative bacteraemia?. A meta-analysis, Lancet Infect Dis, 4, 519, 10.1016/S1473-3099(04)01108-9

Damas, 2006, Combination therapy versus monotherapy: a randomized pilot study on the evolution of inflammatory parameters after ventilator associated pneumonia, Crit Care, 10, 52, 10.1186/cc4879

Bliziotis, 2005, Effect of aminoglycoside and beta-lactam combination therapy versus β-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials, Clin Infect Dis, 41, 149, 10.1086/430912

Paterson, 2003, Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?, Clin Infect Dis, 36, 1006, 10.1086/374243

Kollef, 2005, Antibiotic utilization and outcomes for patients with clinically suspected ventilator-associated pneumonia and negative quantitative BAL culture results, Chest, 128, 2706, 10.1378/chest.128.4.2706

Briceland, 1988, Antibiotic streamlining from combination therapy to monotherapy utilizing an interdisciplinary approach, Arch Intern Med, 148, 2019, 10.1001/archinte.1988.00380090091022

Glowacki, 2003, Antibiotic combinations with redundant antimicrobial spectra: clinical epidemiology and pilot intervention of computer-assisted surveillance, Clin Infect Dis, 37, 59, 10.1086/376623

Grant, 2002, Clinical efficacy and pharmacoeconomics of a continuous-infusion piperacillin-tazobactam program in a large community teaching hospital, Pharmacotherapy, 22, 471, 10.1592/phco.22.7.471.33665

Bailey, 1997, A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides, Clin Infect Dis, 24, 786, 10.1093/clinids/24.5.786

Saravolatz, 2003, Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones, Clin Infect Dis, 37, 1210, 10.1086/378809

Dunbar, 2003, High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigm, Clin Infect Dis, 37, 752, 10.1086/377539

Chan, 1995, Oral versus intravenous antibiotics for community acquired lower respiratory tract infection in a general hospital: open, randomized controlled trial, BMJ, 310, 1360, 10.1136/bmj.310.6991.1360

Siegel, 1996, A prospective randomized study of inpatient I antibiotics for community-acquired pneumonia. The optimal duration of therapy, Chest, 110, 965, 10.1378/chest.110.4.965

Omidvari, 1998, Early transition to oral antibiotic therapy for community-acquired pneumonia: duration of therapy, clinical outcomes, and cost analysis, Respir Med, 92, 1032, 10.1016/S0954-6111(98)90351-1

Al-Eidan, 1999, Sequential antimicrobial therapy: treatment of severe lower respiratory tract infections in children, J Antimicrob Chemother, 44, 709, 10.1093/jac/44.5.709

Przybylski, 1997, A pharmacist-initiated program of intravenous to oral antibiotic conversion, Pharmacotherapy, 17, 271, 10.1002/j.1875-9114.1997.tb03709.x

Li, 2003, Effect of linezolid versus vancomycin on length of hospital stay in patients with complicated skin and soft tissue infections caused by known or suspected methicillin-resistant staphylococci: results from a randomized clinical trial, Surg Infect (Larchmt), 4, 57, 10.1089/109629603764655290

McCollum, 2003, Cost analysis of switching from iv vancomycin to po linezolid for the management of methicillin-resistant Staphylococcus species, Clin Ther, 25, 3173, 10.1016/S0149-2918(03)90101-9

Chassin, 1998, The urgent need to improve health care quality. Institute of Medicine National Roundtable on Health Care Quality, JAMA, 280, 1000, 10.1001/jama.280.11.1000

Institute of Medicine, 2000, Crossing the quality chasm: a new heath system for the 21st century

Institute of Medicine, 1999, Toerr is human: building a safer health system

Kuperman, 2003, Computer physician order entry: benefits, costs, and issues, Ann Intern Med, 139, 31, 10.7326/0003-4819-139-1-200307010-00010

Burke, 2003, Surveillance, reporting, automation, and interventional epidemiology, Infect Control Hosp Epidemiol, 24, 10, 10.1086/502108

Koppel, 2005, Role of computerized physician order entry systems in facilitating medication errors, JAMA, 293, 1197, 10.1001/jama.293.10.1197

Burke, 1991, The HELP system and its application to infection control, J Hosp Infect, 18, 424, 10.1016/0195-6701(91)90052-A

Evans, 1998, A computer-assisted management program fro antibiotics and other antiinfective agents, N Engl J Med, 338, 232, 10.1056/NEJM199801223380406

Evans, 1999, Evaluation of a computer-assisted antibiotic-dose monitor, Ann Pharmacother, 33, 1026, 10.1345/aph.18391

Pestotnik, 1996, Implementing antibiotic practice guidelines through computer-assisted decision support: clinical and financial outcomes, Ann Intern Med, 124, 884, 10.7326/0003-4819-124-10-199605150-00004

Burke, 2001, Maximizing appropriate antibiotic prophylaxis for surgical patients: an update from LDS Hospital, Salt Lake City, Clin Infect Dis, 33, 78, 10.1086/321861

Evans, 1986, Computer surveillance of hospital-acquired infections and antibiotic use, JAMA, 256, 1007, 10.1001/jama.1986.03380080053027

Classen, 1991, Computerized surveillance of adverse drug events in hospital patients, JAMA, 266, 2847, 10.1001/jama.1991.03470200059035

Mullett, 2001, Development and impact of a computerized pediatric antiinfective decision support system, Pediatrics, 108, e75, 10.1542/peds.108.4.e75

Mullett, 2004, Computerized antimicrobial decision support: an offline evaluation of a database-driven empiric antimicrobial guidance program in hospitalized patients with a bloodstream infection, Int J Med Inform, 73, 455, 10.1016/j.ijmedinf.2004.04.002

Shojania, 1998, Reducing vancomycin use utilizing a computer guideline: results of a randomized controlled trial, J Am Med Inform Assoc, 5, 554, 10.1136/jamia.1998.0050554

Rubinstein, 1988, Antibiotic cost reduction by providing cost information, Eur J Clin Pharmacol, 35, 269, 10.1007/BF00558264

Wears, 2005, Computer technology and clinical work: still waiting for Godot, JAMA, 293, 1261, 10.1001/jama.293.10.1261

Nebeker, 2005, High rates of adverse drug events in a highly computerized hospital, Arch Intern Med, 165, 1111, 10.1001/archinte.165.10.1111

Doern, 1994, Clinical impact of rapid in vitro susceptibility testing and bacterial identification, J Clin Microbiol, 32, 1757, 10.1128/JCM.32.7.1757-1762.1994

Byl, 1999, Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia, Clin Infect Dis, 29, 60, 10.1086/520182

Clinical and Laboratory Standards Institute, 2005, Performance standards for antimicrobial susceptibility testing: fifteenth informational supplement M100-S15

Clinical and Laboratory Standards Institute (CLSI), 2002, Analysis and presentation of cumulative antimicrobial susceptibility test data: approved guideline—second edition, CLSI document M39-A

Siberry, 2003, Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro, Clin Infect Dis, 37, 1257, 10.1086/377501

Roger, 2001, Vancomycin-resistant enterococci in health care facilities, N Engl J Med, 345, 768, 10.1056/NEJM200109063451013

Huletsky, 2005, Identification of methicillin-resistant Staphylococcus aureus carriage in less than 1 hour during a hospital surveillance program, Clin Infect Dis, 40, 976, 10.1086/428579

Peterson, 2001, New technology for detecting multidrug-resistant pathogens in the clinical microbiology laboratory, Emerg Infect Dis, 7, 306, 10.3201/eid0702.010233

Davey, 2006, Systematic review of antimicrobial drug prescribing in hospitals, Emerg Infect Dis, 12, 211, 10.3201/eid1202.050145

Iokazu, 2005, Antimicrobial consumption data from pharmacy and nursing records: how good are they?, Infect Control Hosp Epidemiol, 26, 395, 10.1086/502557

2004, National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004, Am J Infect Control, 32, 470, 10.1016/j.ajic.2004.10.001

Zagorski, 2002, The effect of renal dysfunction on antimicrobial use measurements, Clin Infect Dis, 35, 1491, 10.1086/344753

Pelletier, 1985, Hospital usage of parenteral antimicrobial agents: a gradated utilization review and cost containment program, Infect Control, 6, 226, 10.1017/S0195941700061579

McGowan, 1994, Do intensive hospital antibiotic control programs prevent the spread of antibiotic resistance?, Infect Control Hosp Epidemiol, 15, 478, 10.2307/30148498

Duncan, 1997, Controlling use of antimicrobial agents, Infect Control Hosp Epidemiol, 18, 260, 10.2307/30141213

DeLisle, 2001, Antimicrobial management measures to limit resistance: a process-based conceptual framework, Crit Care Med, 29, 121, 10.1097/00003246-200104001-00012

Struelens, 2003, Multidisciplinary antimicrobial management teams: the way forward to control antimicrobial resistance in hospitals, Curr Opin Infect Dis, 16, 305, 10.1097/00001432-200308000-00001

Knox, 2003, Multidisciplinary antimicrobial management and the role of the infectious diseases pharmacist—a UK perspective, J Hosp Infect, 53, 85, 10.1053/jhin.2002.1350

Owens, 2004, Antimicrobial stewardship programs as a means to optimize antimicrobial use, Pharmacotherapy, 24, 896, 10.1592/phco.24.9.896.36101

Paskovaty, 2005, A multidisciplinary approach to antimicrobial stewardship: evolution into the 21st century, Int J Antimicrob Agents, 25, 1, 10.1016/j.ijantimicag.2004.09.001

MacDougall, 2005, Antimicrobial stewardship programs in health care systems, Clin Microbiol Rev, 18, 638, 10.1128/CMR.18.4.638-656.2005