Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Developmental Cell - Tập 3 Số 6 - Trang 889-901 - 2002
Hiroshi Takayanagi1,2, Sunhwa Kim1, Takako Koga1,2, Hiroshi Nishina3, Masashi Isshiki4, Hiroki Yoshida5,2, Akio Saiura6, Miho Isobe1,2, Taeko Yokochi1, Jun‐ichiro Inoue7, Erwin F. Wagner8, Tak W. Mak9, Tatsuhiko Kodama6, Tadatsugu Taniguchi1
1Department of Immunology, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
2PRESTO, Japan Science and Technology Corporation (JST), Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan
3Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
4Department of Nephrology and Endocrinology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
5Department of Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
6Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan
7Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
8Research Institute of Molecular Pathology (IMP), Dr Bohr Gasse 7, A-1030, Vienna, Austria
9Advanced Medical Discovery Institute and Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada

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