Khử hoạt tính zearalenone (ZEN) và deoxynivalenol (DON) trong thức ăn hoàn chỉnh cho lợn con cai sữa: Hiệu quả của enzyme phân hủy ZEN ZenA và natri metabisulfit (SBS) như phụ gia thức ăn

Armuzzi A, Candelli M, Zocco MA, Andreoli A, De LA, Nista EC, Miele L, Cremonini F, Cazzato IA, Grieco A, Gasbarrini G, Gasbarrini A (2002) Review article: breath testing for human liver function assessment. Aliment Pharmacol Ther 16:1977–1996 Avantaggiato G, Solfrizzo M, Visconti A (2005) Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins. Food Addit Contam 22:379–388 Binder SB, Schwartz-Zimmermann HE, Varga E, Bichl G, Michlmayr H, Adam G, Berthiller F (2017) Metabolism of zearalenone and its major modified forms in pigs. Toxins 9. https://doi.org/10.3390/toxins9020056 Bönisch K, Brocke AL, Dippel S (2017) German Pig-Scoring Key (DSBS). https://www.fli.de/de/institute/institut-fuer-tierschutz-undtierhaltung-itt/forschungsbereiche-arbeitsgruppen/ag-schweine/deutscherschweine-boniturschluessel/ Bouchard MJ, Chorfi Y, Letourneau-Montminy MP, Guay F (2019) Effects of deoxynivalenol and sodium meta-bisulphite on nutrient digestibility in growing pigs. Arch Anim Nutr 73:360–373. https://doi.org/10.1080/1745039x.2019.1641369 Dänicke S, Brezina U (2013) Invited review: kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: Consequences for diagnosis of exposure and intoxication and carry over. Food Chem Toxicol 60:58–75 Dänicke S, Beineke A, Goyarts T, Valenta H, Beyer M, Humpf HU (2008) Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the 13C-methacetin breath test. Arch Anim Nutr 62:263–286 Dänicke S, Kersten S, Valenta H, Breves G (2012) Inactivation of deoxnivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects. Mycotoxin Res 28:199–218 Dänicke S, Pahlow G, Beyer M, Goyarts T, Breves G, Valenta H, Humpf H-U (2010) Investigations on the kinetics of the concentration of deoxynivalenol (DON) and of microbial spoilage of wheat grain preserved with sodium metabisulphite (Na2S2O5, SBS) and propionic acid at various moisture contents. Arch Anim Nutr 64:190–203 Dänicke S, Pahlow G, Goyarts T, Rohweder D, Wilkerling K, Breves G, Valenta H, Döll S (2009) Effects of increasing concentrations of sodium metabisulphite (Na2S2O5, SBS) on deoxynivalenol (DON) concentration and microbial spoilage of triticale kernels preserved without and with propionic acid at various moisture contents. Mycotoxin Res 25:215–223 Dänicke S, Valenta H, Döll S (2004) On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Arch Anim Nutr 58:169–180 Dänicke S, Valenta H, Gareis M, Lucht HW, von Reichenbach H (2005) On the effects of a hydrothermal treatment of deoxynivalenol (DON)-contaminated wheat in the presence of sodium metabisulphite (Na2S2O5) on DON reduction and on piglet performance. Anim Feed Sci Tech 118:93–108 Dänicke S, Winkler J (2015) Invited review: diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over). Food Chem Toxicol 84:225–249. https://doi.org/10.1016/j.fct.2015.08.009 Daniel JW (1986) Metabolic aspects of antioxidants and preservatives. Xenobiotica; the Fate of Foreign Compounds in Biological Systems 16:1073–1078 Döll S, Dänicke S (2004) In vivo detoxification of Fusarium toxins. Arch Anim Nutr 58:419–441 Döll S, Dänicke S (2011) The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding. Prev Vet Med 102:132–145. https://doi.org/10.1016/j.prevetmed.2011.04.008 Döll S, Dänicke S, Ueberschär KH, Valenta H, Schnurrbusch U, Ganter M, Klobasa F, Flachowsky G (2003) Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch Tierernahr 57:311–334 Döll S, Dänicke S, Valenta H, Flachowsky G (2004) In vitro studies on the evaluation of mycotoxin detoxifying agents for their efficacy on deoxynivalenol and zearalenone. Arch Anim Nutr 58:311–324 European Commission (2006) Commission recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Off J Eur Union 229:7–9 European Commission (2013) Commission implementing regulation (EU) No 1016/2013 of 23 October 2013 concerning the authorisation of a preparation of a micro-organism strain DSM 11798 of the Coriobacteriaceae family as a feed additive for pigs. Off J Eur Union L282:36–43 European Food Safety Authority (2011) Scientific Opinion on the risks for public health related to the presence of zearalenone in food. EFSA J 9:2197 European Food Safety Authority (2016) Scientific Opinion on the re-evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228) as food additives. EFSA J 14(4):1–151. https://doi.org/10.2903/j.efsa.2016.4438 European Food Safety Authority (2017) Risks for animal health related to the presence of zearalenone and its modified forms in feed. EFSA Journal 15:e04851. https://doi.org/10.2903/j.efsa.2017.4851 Frobose HL, Fruge ED, Tokach MD, Hansen EL, DeRouchey JM, Dritz SS, Goodband RD, Nelssen JL (2015) The influence of pelleting and supplementing sodium metabisulfite (Na2S2O5) on nursery pigs fed diets contaminated with deoxynivalenol. Anim Feed Sci Tech 210:152–164. https://doi.org/10.1016/j.anifeedsci.2015.09.020 Frobose HL, Stephenson EW, Tokach MD, DeRouchey JM, Woodworth JC, Dritz SS, Goodband RD (2017) Effects of potential detoxifying agents on growth performance and deoxynivalenol (DON) urinary balance characteristics of nursery pigs fed DON-contaminated wheat. J Anim Sci 95:327–337. https://doi.org/10.2527/jas.2016.0664 Fruhauf S, Novak B, Nagl V, Hackl M, Hartinger D, Rainer V, Labudova S, Adam G, Aleschko M, Moll WD, Thamhesl M, Grenier B (2019) Biotransformation of the mycotoxin zearalenone to its metabolites hydrolyzed zearalenone (HZEN) and decarboxylated hydrolyzed zearalenone (DHZEN) diminishes its estrogenicity in vitro and in vivo. Toxins 11. https://doi.org/10.3390/toxins11080481 Goyarts T, Dänicke S, Rothkötter H-J, Spilke J, Tiemann U, Schollenberger M (2005) On the effects of a chronic deoxynivalenol intoxication on performance, haematological and serum parameters of pigs when diets are offered either for ad libitum consumption or fed restrictively. J Vet Med A Physiol Pathol Clin Med 52:305–314 Gruber-Dorninger C, Faas J, Doupovec B, Aleschko M, Stoiber C, Höbartner-Gußl A, Schöndorfer K, Killinger M, Zebeli Q, Schatzmayr D (2021) Metabolism of zearalenone in the rumen of dairy cows with and without application of a zearalenone-degrading enzyme. Toxins (Basel) 13. https://doi.org/10.3390/toxins13020084 Gruber-Dorninger C, Killinger M, Höbartner-Gußl A, Rosen R, Doupovec B, Aleschko M, Schwartz-Zimmermann H, Greitbauer O, Marković Z, Stanković M, Schöndorfer K, Vukmirovic D, Wein S (2023) Schatzmayr D (2023) Enzymatic degradation of zearalenone in the gastrointestinal tract of pigs, chickens, and rainbow trout. Toxins 15:48. https://doi.org/10.3390/toxins15010048 Gunnison AF (1981) Sulfite toxicity - a critical-review of in vitro and in vivo data. Food Cosmet Toxicol 19:667–682 Liu A, Yang Y, Guo J, Gao Y, Wu Q, Zhao L, Sun L-H, Wang X (2022) Cytochrome P450 enzymes mediated by DNA methylation is involved in deoxynivalenol-induced hepatoxicity in piglets. Animal Nut (Zhongguo xu mu shou yi xue hui) 9:269–279. (eng. Epub 2022 Feb 21) Moritz A (ed) (2014) Klinische Labordiagnostik in der Tiermedizin: Mit 286 Tabellen; der neue Kraft/Dürr, 7th edn. Schattauer, Stuttgart Mwaniki AW, Buis QR, Trott D, Huber L-A, Yang C, Kiarie EG (2021) Comparative efficacy of commercially available deoxynivalenol detoxifying feed additives on growth performance, total tract digestibility of components, and physiological responses in nursery pigs fed diets formulated with naturally contaminated corn. Transl Anim Sci txab050. https://doi.org/10.1093/tas/txab050 Ozturk OH, Oktar S, Aydin M, Kucukatay V (2010) Effect of sulfite on antioxidant enzymes and lipid peroxidation in normal and sulfite oxidase-deficient rat erythrocytes. J Physiol Biochem 66:205–212. https://doi.org/10.1007/s13105-010-0025-7 Paulick M, Rempe I, Kersten S, Schatzmayr D, Schwartz-Zimmermann HE, Danicke S (2015a) Effects of increasing concentrations of sodium sulfite on deoxynivalenol and deoxynivalenol sulfonate concentrations of maize kernels and maize meal preserved at various moisture content. Toxins 7:791–811. https://doi.org/10.3390/toxins7030791 Paulick M, Winkler J, Kersten S, Schatzmayr D, Schwartz-Zimmermann HE, Dänicke S (2015b) Studies on the bioavailability of deoxynivalenol (DON) and DON Sulfonate (DONS) 1, 2, and 3 in pigs fed with sodium sulfite-treated DON-contaminated maize. Toxins 7:4622–4644. https://doi.org/10.3390/toxins7114622 Paulick M, Winkler J, Kersten S, Schatzmayr D, Frahm J, Kluess J, Schwartz-Zimmermann HE, Dänicke S (2018) Effects of oral exposure to sodium sulphite-treated deoxynivalenol (DON)-contaminated maize on performance and plasma concentrations of toxins and metabolites in piglets. Arch Anim Nutr 72:42–57. https://doi.org/10.1080/1745039X.2017.1415550 Reiner G, Kuehling J, Loewenstein F, Lechner M, Becker S (2021) Swine inflammation and necrosis syndrome (SINS). Animals 11. https://doi.org/10.3390/ani11061670 Rempe I, Kersten S, Valenta H, Dänicke S (2013) Hydrothermal treatment of naturally contaminated maize in the presence of sodium metabisulfite, methylamine and calcium hydroxide; effects on the concentration of zearalenone and deoxynivalenol. Mycotoxin Res 29:169–175. https://doi.org/10.1007/s12550-013-0166-y Rose AH (1993) Sulphur dioxide and other preservatives. J Wine Res 4:43–47 Schatzmayr G, Streit E (2013) Global occurrence of mycotoxins in the food and feed chain: facts and figures. World Mycotoxin J 6:213–222. https://doi.org/10.3920/WMJ2013.1572 Schwartz HE, Hametner C, Slavik V, Greitbauer O, Bichl G, Kunz-Vekiru E, Schatzmayr D, Berthiller F (2013) Characterization of three deoxynivalenol sulfonates formed by reaction of deoxynivalenol with sulfur reagents. J Agr Food Chem 61:8941–8948. https://doi.org/10.1021/jf403438b Schwartz-Zimmermann HE, Fruhmann P, Dänicke S, Wiesenberger G, Caha S, Weber J, Berthiller F (2015) Metabolism of deoxynivalenol and deepoxy-deoxynivalenol in broiler chickens, pullets, roosters and turkeys. Toxins 7:4706–4729. https://doi.org/10.3390/toxins7114706 Schwartz-Zimmermann HE, Hametner C, Nagl V, Slavik V, Moll W-D, Berthiller F (2014a) Deoxynivalenol (DON) sulfonates as major DON metabolites in rats: from identification to biomarker method development, validation and application. Anal Bioanal Chem 406:7911–7924. https://doi.org/10.1007/s00216-014-8252-3 Schwartz-Zimmermann HE, Paulick M, Dänicke S, Schatzmayr D, Berthiller F (2014b) Determination of deoxynivalenol sulphonates in cereal samples: method development, validation and application. World Mycotoxin J 7:233–245. https://doi.org/10.3920/Wmj2013.1684 Tolosa J, Rodríguez-Carrasco Y, Ruiz MJ, Vila-Donat P (2021) Multi-mycotoxin occurrence in feed, metabolism and carry-over to animal-derived food products: a review. Food Chem Toxicol 158 Tran AT, Kluess J, Berk A, Paulick M, Frahm J, Schatzmayr D, Winkler J, Kersten S, Dänicke S (2018) Detoxification of Fusarium-contaminated maize with sodium sulphite - in vivo efficacy with special emphasis on mycotoxin residues and piglet health. Arch Anim Nutr 72:58–75. https://doi.org/10.1080/1745039X.2017.1418047 van Thanh B, Lessard M, Chorfi Y, Guay F (2015) The efficacy of anti-mycotoxin feed additives in preventing the adverse effects of wheat naturally contaminated with Fusarium mycotoxins on performance, intestinal barrier function and nutrient digestibility and retention in weanling pigs. Can J Anim Sci 95:197–209. https://doi.org/10.4141/cjas-2014-126 Verband Deutscher Landwirtschaftlicher Untersuchungs- und Forschungsanstalten (1976) Methoden No. 3.1 (Feuchtigkeit), No. 4.1.1 (Rohprotein, Kjeldahl-Aufschluss), No. 5.1.1 (Rohfett), No. 6.1.1 (Rohfaser, Weender-Verfahren, halbautomatisch), No. 6.5.1 (Neutrale Detergentien-Faser, aNDFOM). In: Handbuch der Landwirtschaftlichen Versuchs- und Untersuchungsmethodik (VDLUFA-Methodenbuch), Band III, Die Untersuchung von Futtermitteln, 3. Auflage; einschließlich 1.-8. Ergänzungslieferung, VDLUFA-Verlag Darmstadt Wan D, Huang L, Pan Y, Wu Q, Chen D, Tao Y, Wang X, Liu Z, Li J, Wang L, Yuan Z (2014) Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry, and online radiometric detection. J Agric Food Chem 62:288–296. https://doi.org/10.1021/jf4047946 Warth B, Sulyok M, Fruhmann P, Mikula H, Berthiller F, Schuhmacher R, Hametner C, Abia WA, Adam G, Frohlich J, Krska R (2012) Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid Communications in Mass Spectrometry: RCM 26:1533–1540. https://doi.org/10.1002/rcm.6255 Young JC, Subryan LM, Potts D, Mclaren ME, Gobran FH (1986) Reduction in levels of deoxynivalenol in contaminated wheat by chemical and physical treatment. J Agr Food Chem 34:461–465 Yu C, Lu P, Liu S, Li Q, Xu E, Gong J, Liu S, Yang C (2021) Efficiency of deoxynivalenol detoxification by microencapsulated sodium metabisulfite assessed via an in vitro bioassay based on intestinal porcine epithelial cells. ACS Omega 6:8382–8393. https://doi.org/10.1021/acsomega.1c00117 Ziron M (2014) Klauengesundheit bei Zuchtsauen: Strategien für langlebige Tiere. AgrarPraxis kompakt. DLG-Verl, Frankfurt am Main