Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors

Katarzyna A. Cieslik1, Rajagopal V. Sekhar2, Alejandro Granillo1, Anilkumar K. Reddy1,3, Guillermo Medrano1, Celia Pena Heredia1, Mark L. Entman1, Dale J. Hamilton4,5, Shumin Li4, Erin L. Reineke4, Anisha A. Gupte4,5, Aijun Zhang4,5, George E. Taffet5,1,6
1Division of Cardiovascular Sciences and the DeBakey Heart Center, Department of Medicine, Baylor College of Medicine, Houston, Texas
2Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, Texas
3Indus Instruments, Webster, Texas
4Center for Bioenergetics, Houston Methodist Hospital Research Institute, Texas
5Department of Medicine, Houston Methodist, Texas
6Section of Geriatrics, Department of Medicine, Baylor College of Medicine, Houston, Texas

Tóm tắt

Từ khóa


Tài liệu tham khảo

Dai, 2015, Cardiovascular physiology in the older adults, J Geriatr Cardiol, 12, 196

Vanoverschelde, 1993, Contribution of left ventricular diastolic function to exercise capacity in normal subjects, J Appl Physiol (1985), 74, 2225, 10.1152/jappl.1993.74.5.2225

Upadhya, 2015, Heart failure with preserved ejection fraction in the elderly: scope of the problem, J Mol Cell Cardiol, 83, 73, 10.1016/j.yjmcc.2015.02.025

Douglas, 2003, The left atrium: a biomarker of chronic diastolic dysfunction and cardiovascular disease risk, J Am Coll Cardiol, 42, 1206, 10.1016/S0735-1097(03)00956-2

Medrano, 2016, Left atrial volume and pulmonary artery diameter are noninvasive measures of age-related diastolic dysfunction in mice, J Gerontol A Biol Sci Med Sci, 71, 1141, 10.1093/gerona/glv143

Tsang, 2001, Left atrial volume: important risk marker of incident atrial fibrillation in 1655 older men and women, Mayo Clin Proc, 76, 467, 10.4065/76.5.467

Shaikh, 2013, Left atrial volumes and associated stroke subtypes, BMC Neurol, 13, 149, 10.1186/1471-2377-13-149

Zieman, 2005, Mechanisms, pathophysiology, and therapy of arterial stiffness, Arterioscler Thromb Vasc Biol, 25, 932, 10.1161/01.ATV.0000160548.78317.29

Cooper, 1994, The vasculopathy of aging, J Gerontol, 49, B191, 10.1093/geronj/49.5.B191

Lesnefsky, 2016, Mitochondrial metabolism in aging heart, Circ Res, 118, 1593, 10.1161/CIRCRESAHA.116.307505

Hyyti, 2010, Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice, Am J Physiol Heart Circ Physiol, 299, H868, 10.1152/ajpheart.00931.2009

Hansford, 1978, Lipid oxidation by heart mitochondria from young adult and senescent rats, Biochem J, 170, 285, 10.1042/bj1700285

McMillin, 1993, Mitochondrial metabolism and substrate competition in the aging Fischer rat heart, Cardiovasc Res, 27, 2222, 10.1093/cvr/27.12.2222

Cieslik, 2011, Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart, J Mol Cell Cardiol, 50, 248, 10.1016/j.yjmcc.2010.10.019

Wang, 2015, Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries, J Mol Cell Cardiol, 83, 101, 10.1016/j.yjmcc.2015.02.004

Aquilano, 2014, Glutathione: new roles in redox signaling for an old antioxidant, Front Pharmacol, 5, 196, 10.3389/fphar.2014.00196

Michael, 2011, The ageing lens and cataract: a model of normal and pathological ageing, Philos Trans R Soc Lond B Biol Sci, 366, 1278, 10.1098/rstb.2010.0300

Xiong, 2011, S-glutathionylation: from molecular mechanisms to health outcomes, Antioxid Redox Signal, 15, 233, 10.1089/ars.2010.3540

Aruoma, 1989, The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid, Free Radic Biol Med, 6, 593, 10.1016/0891-5849(89)90066-X

Nguyen, 2013, Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione, Aging Cell, 12, 415, 10.1111/acel.12073

Moreno-Ulloa, 2015, Recovery of indicators of mitochondrial biogenesis, oxidative stress, and aging with (-)-epicatechin in senile mice, J Gerontol A Biol Sci Med Sci, 70, 1370, 10.1093/gerona/glu131

Taffet, 1996, Noninvasive indexes of cardiac systolic and diastolic function in hyperthyroid and senescent mouse, Am J Physiol, 270, H2204

Hartley, 1997, Noninvasive determination of pulse-wave velocity in mice, Am J Physiol, 273, H494

Zuker, 2003, Mfold web server for nucleic acid folding and hybridization prediction, Nucleic Acids Res, 31, 3406, 10.1093/nar/gkg595

SantaLucia, 1998, A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics, Proc Natl Acad Sci USA, 95, 1460, 10.1073/pnas.95.4.1460

Peyret, 2000, Melt Curve Analysis for Each Primer Pair Resulted in a Single Peak Indicating a Single PCR Product

Bustin, 2009, The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments, Clin Chem, 55, 611, 10.1373/clinchem.2008.112797

Cordero-Reyes, 2014, Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function, J Mol Cell Cardiol, 68, 98, 10.1016/j.yjmcc.2013.12.029

Hamilton, 2016, Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure, Am J Physiol Heart Circ Physiol, 310, H667, 10.1152/ajpheart.00746.2015

Sano, 2001, ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts, Circ Res, 89, 661, 10.1161/hh2001.098873

Lakshminarayanan, 2001, Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia, Am J Pathol, 159, 1301, 10.1016/S0002-9440(10)62517-5

Trial, 2017, Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis, Basic Res Cardiol, 112, 34, 10.1007/s00395-017-0623-4

Zhang, 2016, NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice, Science, 352, 1436, 10.1126/science.aaf2693

Cieslik, 2015, Mesenchymal stem cell-derived inflammatory fibroblasts promote monocyte transition into myeloid fibroblasts via an IL-6-dependent mechanism in the aging mouse heart, FASEB J, 29, 3160, 10.1096/fj.14-268136

Dai, 2012, Cardiac aging: from molecular mechanisms to significance in human health and disease, Antioxid Redox Signal, 16, 1492, 10.1089/ars.2011.4179

Cieslik, 2014, Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts, J Mol Cell Cardiol, 70, 56, 10.1016/j.yjmcc.2013.10.017

Tsai, 2015, TNF-α down-regulates sarcoplasmic reticulum Ca²⁺ ATPase expression and leads to left ventricular diastolic dysfunction through binding of NF-κB to promoter response element, Cardiovasc Res, 105, 318, 10.1093/cvr/cvv008

Balderas-Villalobos, 2013, Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome, Am J Physiol Heart Circ Physiol, 305, H1344, 10.1152/ajpheart.00211.2013

Deckert-Schlüter, 1997, Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis, J Neuroimmunol, 76, 167, 10.1016/S0165-5728(97)00047-7

Suzuki, 2000, IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii, J Immunol, 164, 5375, 10.4049/jimmunol.164.10.5375

Gazzinelli, 1996, In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha, J Immunol, 157, 798, 10.4049/jimmunol.157.2.798

Sikka, 2013, Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age, Exp Gerontol, 48, 128, 10.1016/j.exger.2012.11.001

Lenaz, 1997, Mitochondrial complex I defects in aging, Mol Cell Biochem, 174, 329, 10.1023/A:1006854619336

Brown, 2017, Expert consensus document: Mitochondrial function as a therapeutic target in heart failure, Nat Rev Cardiol, 14, 238, 10.1038/nrcardio.2016.203

Sekhar, 2011, Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation, Am J Clin Nutr, 94, 847, 10.3945/ajcn.110.003483

Pérez, 2009, Is the oxidative stress theory of aging dead, Biochim Biophys Acta, 1790, 1005, 10.1016/j.bbagen.2009.06.003

Ristow, 2009, Antioxidants prevent health-promoting effects of physical exercise in humans, Proc Natl Acad Sci USA, 106, 8665, 10.1073/pnas.0903485106

Dey, 2016, Compartment-specific control of reactive oxygen species scavenging by antioxidant pathway enzymes, J Biol Chem, 291, 11185, 10.1074/jbc.M116.726968

Owada, 2017, Resolution of mitochondrial oxidant stress improves aged-cardiovascular performance, Coron Artery Dis, 28, 33, 10.1097/MCA.0000000000000434

Dai, 2009, Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging, Circulation, 119, 2789, 10.1161/CIRCULATIONAHA.108.822403

Qin, 2013, Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart, J Am Heart Assoc, 2, e000184, 10.1161/JAHA.113.000184

Grek, 2013, Causes and consequences of cysteine S-glutathionylation, J Biol Chem, 288, 26497, 10.1074/jbc.R113.461368

Pan, 2005, Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells, Biochem J, 390, 447, 10.1042/BJ20050141

Zhong, 2003, L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent, Curr Opin Clin Nutr Metab Care, 6, 229, 10.1097/00075197-200303000-00013