Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2

American Association for the Advancement of Science (AAAS) - Tập 273 Số 5275 - Trang 645-647 - 1996
Mineto Yokoi1, Katsunori Kobayashi2, Toshiya Manabe2, Tomoyuki Takahashi2, Isako Sakaguchi3, Goro Katsuura3, Ryuichi Shigemoto4, Hitoshi Ohishi4, Sakashi Nomura5, Kenji Nakamura6, Kazuki Nakao6, Motoya Katsuki6, Shigetada Nakanishi1
1M. Yokoi and S. Nakanishi, Department of Biological Sciences (formerly Institute for Immunology), Kyoto University Faculty of Medicine, Kyoto 606, Japan.
2K. Kobayashi, T. Manabe, T. Takahashi, Department of Neurophysiology, Institute for Brain Research, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan.
3I. Sakaguchi and G. Katsuura, Aburahi Laboratories, Shionogi and Company, Ltd., Shiga 520-34, Japan.
4R. Shigemoto and H. Ohishi, Department of Morphological Brain Science, Kyoto University Faculty of Medicine, Kyoto 606, Japan.
5S. Nomura, College of Medical Technology, Kyoto University, Kyoto 606, Japan.
6K. Nakamura, K. Nakao, M. Katsuki, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812, Japan.

Tóm tắt

Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.

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American Association for the Advancement of Science (AAAS)

Tập 273 Số 5275

645-647

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